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CAS 76-05-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 9875612/10/2020

TRIFLUOROACETIC ACID

Trifluoroacetic Acid

TRIFLUOROACETIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 76-05-1

CAS 76-05-1PubChem CID 6422

Trifluoroacetic acid

Trifluoroacetic acid is a monocarboxylic acid that is the trifluoro derivative of acetic acid. It has a role as a reagent and a human xenobiotic metabolite. It is functionally related to an acetic acid. It is a conjugate acid of a trifluoroacetate. — ChEBI

IUPAC name: 2,2,2-trifluoroacetic acid

Molecular formula: C2HF3O2
Molecular weight: 114.02 g/mol
Exact mass: 113.99286376 Da
XLogP3: 0.9
Topological polar surface area: 37.3 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 0

Also known as

Perfluoroacetic acidTrifluoracetic acidTrifluoroethanoic acidAcetic acid, trifluoro-Kyselina trifluoroctovaAcetic acid, 2,2,2-trifluoro-TrifluoressigsaeureBRN 0742035

16 more reported names

acide trifluoroacetiqueE5R8Z4G708NSC-77366CHEBI:45892Acid, TrifluoroaceticTRIFLUOROACETIC ACID (II)TRIFLUOROACETIC ACID [II]RefChem:6326trifluoroacetic acid (tfa)trifluoroacetic acid . . . %200-929-3trifluoroaceticacidTFAtrifluoro-acetic acidtrifluoro acetic acidCF3COOH

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:45892
ChEMBL:CHEMBL506259
EPA DTXSID:DTXSID9041578
PubMed:23122087
PubMed:23112895
PubMed:23092381
PubMed:23077615
PubMed:23075170
PubMed:23059992
PubMed:23041391
PubMed:23035427
PubMed:23030272
PubMed:22999476
PubMed:22989069
PubMed:22971183

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TRIFLUOROACETIC ACID

INCI name

TRIFLUOROACETIC ACID

Description

Trifluoroacetic Acid

Record provenance

Inventory reference: 98756
Imported identity: TRIFLUOROACETIC ACID
Source update: 12/10/2020

European Commission CosIng source notes

Annex records for TRIFLUOROACETIC ACID

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Key data

CAS

76-05-1

200-929-3

Restriction

—

Function

pH ADJUSTERS: Controlling the pH of cosmetic products.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#29177 · TRIFLUOROACETIC ACID

Ingredients with overlapping formulation functions

PROPIONIC ACIDANTIMICROBIAL, FRAGRANCE, pH ADJUSTERS, PRESERVATIVE

S-DNA APTAMER-2ANTIOXIDANT; REDUCING; SKIN PROTECTING; UV FILTER; pH ADJUSTERS

SODIUM 3-MERCAPTOPROPANE SULFONATEDENATURANT, HAIR CONDITIONING, pH ADJUSTERS, SURFACE MODIFIER

SODIUM ANISATEANTIMICROBIAL, FLAVOURING, FRAGRANCE, pH ADJUSTERS

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TRIFLUOROACETIC ACID appears in the CosIng inventory

The CosIng inventory lists TRIFLUOROACETIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TRIFLUOROACETIC ACID is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TRIFLUOROACETIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TRIFLUOROACETIC ACID carries the following function designation(s):

pH ADJUSTERS

CAS 76-05-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TRIFLUOROACETIC ACID

This page reproduces the CosIng inventory entry for TRIFLUOROACETIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TRIFLUOROACETIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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