Is ARTEPILLIN C safe to use in EU cosmetics?

ARTEPILLIN C is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 72944-19-5?

CAS 72944-19-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains ARTEPILLIN C?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9769111/10/2019

ARTEPILLIN C

2-Propenoic acid, 3-[4-hydroxy-3,5-bis(3-methyl-2-buten-1-yl)phenyl]-, (2E)-

ARTEPILLIN C is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 72944-19-5

CAS 72944-19-5PubChem CID 5472440

Artepillin C

artepillin C has been reported in Artemisia palustris, Baccharis polyphylla, and other organisms with data available. — LOTUS - the natural products occurrence database

IUPAC name: (E)-3-[4-hydroxy-3,5-bis(3-methylbut-2-enyl)phenyl]prop-2-enoic acid

Molecular formula: C19H24O3
Molecular weight: 300.4 g/mol
Exact mass: 300.17254462 Da
XLogP3: 5.4
Topological polar surface area: 57.5 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

artepillin3-(4-Hydroxy-3,5-bis(3-methyl-2-butenyl)phenyl)-2-propenoic acid(E)-3-(4-hydroxy-3,5-bis(3-methylbut-2-enyl)phenyl)prop-2-enoic acidRefChem:114270ArtepillinCNSC-718732FS-6839(E)-3-(4-Hydroxy-3,5-bis(3-methylbut-2-en-1-yl)phenyl)acrylic acid

9 more reported names

(2E)-3-[4-HYDROXY-3,5-BIS(3-METHYLBUT-2-EN-1-YL)PHENYL]PROP-2-ENOIC ACID2-Propenoic acid, 3-(4-hydroxy-3,5-bis(3-methyl-2-butenyl)phenyl)-, (E)-CCRIS 8746GTPL6302KABCFARPAMSXCC-JXMROGBWSA-NEX-A14881HY-N10319DA-71049CS-0379815

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL456309
EPA DTXSID:DTXSID201317933
PubMed:23133611

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ARTEPILLIN C

INCI name

ARTEPILLIN C

Description

2-Propenoic acid, 3-[4-hydroxy-3,5-bis(3-methyl-2-buten-1-yl)phenyl]-, (2E)-

Record provenance

Inventory reference: 97691
Imported identity: ARTEPILLIN C
Source update: 11/10/2019

European Commission CosIng source notes

Annex records for ARTEPILLIN C

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Key data

CAS

72944-19-5

—

Restriction

—

Function

HUMECTANT: Retaining and/or preserving the moisture in a product during use.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#2381 · ARTEPILLIN C

Ingredients with overlapping formulation functions

ARTEMISIA FUKUDO EXTRACTHUMECTANT, SKIN CONDITIONING

ARTEMISIA GLACIALIS EXTRACTHUMECTANT, SKIN CONDITIONING

ARTEMISIA JAPONICA EXTRACTHUMECTANT, SKIN PROTECTING

ARTEMISIA PRINCEPS CALLUS EXTRACTANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

ARTHROSPIRA PLATENSIS CULTURE CONDITIONED MEDIAANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

ARTHROSPIRA PLATENSIS EXTRACTANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

ASCOPHYLLUM NODOSUM/FUCUS VESICULOSUS EXTRACTHUMECTANT, SKIN CONDITIONING

ASCORBYL NICOTINATEHUMECTANT, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ARTEPILLIN C appears in the CosIng inventory

The CosIng inventory lists ARTEPILLIN C as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ARTEPILLIN C is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ARTEPILLIN C is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ARTEPILLIN C carries the following function designation(s):

CAS 72944-19-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for ARTEPILLIN C

This page reproduces the CosIng inventory entry for ARTEPILLIN C from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ARTEPILLIN C and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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