Is GUANAZOLE safe to use in EU cosmetics?

GUANAZOLE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 1455-77-2?

CAS 1455-77-2 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains GUANAZOLE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9715615/04/2019

GUANAZOLE

1,2,4-triazolidine-3,5-diimine; 1H-1,2,4-Triazole-3,5-diamine; 3,5-Diamino-1,2,4-triazole; 4H-1,2,4-triazole-3,5-diamine

GUANAZOLE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 1455-77-2

CAS 1455-77-2PubChem CID 15078

3,5-Diamino-1,2,4-triazole

Guanazole is an aromatic amine that is 1,2,4-triazole substituted at positions 3 and 5 by amino groups. It has a role as an antineoplastic agent, a DNA synthesis inhibitor and an EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor. It is an aromatic amine and a member of triazoles. — ChEBI

IUPAC name: 1H-1,2,4-triazole-3,5-diamine

Molecular formula: C2H5N5
Molecular weight: 99.10 g/mol
Exact mass: 99.05449518 Da
XLogP3: -0.7
Topological polar surface area: 93.6 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

Guanazole3,5-Diamino-s-triazole3,5-Diamino-1H-1,2,4-triazoles-Triazole, 3,5-diamino-NCI-C04819NSC 1895MC 51762NSC-1895

16 more reported names

NSC1895I01TWM5267CHEBI:75425NSC-166592NSC-167391NSC-167392RefChem:144636215-937-24H-1,2,4-triazole-3,5-diamine503-88-81,2,4-Triazolidine, 3,5-diimino-1H-124-Triazole-35-diamineAI3-51272BIDD:GT03663,5-Diamino-1h-[1,2,4]triazoleGuanazole (VAN)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:75425
ChEMBL:CHEMBL56973
EPA DTXSID:DTXSID0025367
PubMed:22982389
PubMed:22544278
PubMed:22489838
PubMed:22259520
PubMed:22220521
PubMed:22100733
PubMed:22090877
PubMed:22029279
PubMed:21754014
PubMed:21727971
PubMed:21625504
PubMed:21588872

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for GUANAZOLE

INCI name

GUANAZOLE

Description

1,2,4-triazolidine-3,5-diimine; 1H-1,2,4-Triazole-3,5-diamine; 3,5-Diamino-1,2,4-triazole; 4H-1,2,4-triazole-3,5-diamine

Record provenance

Inventory reference: 97156
Imported identity: GUANAZOLE
Source update: 15/04/2019

European Commission CosIng source notes

Annex records for GUANAZOLE

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Key data

CAS

1455-77-2

215-937-2

Restriction

—

Function

NOT REPORTED: No function currently reported.

Ingredients with overlapping formulation functions

GLYCERYL LAURATE DIACETATENOT REPORTED, SKIN CONDITIONING

GOAT MILK EXTRACTNOT REPORTED

GOLD ACETYLMETHIONATENOT REPORTED

GOSSYPIUM HERBACEUM LEAF EXTRACTNOT REPORTED

HAEMATOXYLUM CAMPECHIANUM POWDERNOT REPORTED

HAIR EXTRACTNOT REPORTED

HDI ISOCYANURATE TRIMERNOT REPORTED

HEPTAPEPTIDE-43NOT REPORTED

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How GUANAZOLE appears in the CosIng inventory

The CosIng inventory lists GUANAZOLE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

GUANAZOLE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

GUANAZOLE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, GUANAZOLE carries the following function designation(s):

NOT REPORTED

CAS 1455-77-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for GUANAZOLE

This page reproduces the CosIng inventory entry for GUANAZOLE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research GUANAZOLE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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