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CAS 10097-02-6 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 9715215/04/2019

DIMETHYLOLBUTYRIC ACID

2,2-Bis(hydroxymethyl)butyric acid

DIMETHYLOLBUTYRIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 10097-02-6

CAS 10097-02-6PubChem CID 3301396

2,2-Bis(hydroxymethyl)butanoic acid

IUPAC name: 2,2-bis(hydroxymethyl)butanoic acid

Molecular formula: C6H12O4
Molecular weight: 148.16 g/mol
Exact mass: 148.07355886 Da
XLogP3: -0.9
Topological polar surface area: 77.8 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

Butanoic acid, 2,2-bis(hydroxymethyl)-2,2-Dimethylolbutyric Aciddimethylolbutyric aciddimethylolbutanoic acid2,2-dimethylolbutanoic acidUNII-42UJ0Z625VNIKKAMER BA42UJ0Z625V

16 more reported names

EC 424-090-1JVYDLYGCSIHCMR-UHFFFAOYSA-BIS(HYDROXYMETHYL)BUTANOIC ACID, 2,2-RefChem:80945DIMETHYLOLBUTYRIC ACID [INCI]424-090-1600-143-4InChI=1/C6H12O4/c1-2-6(3-7,4-8)5(9)10/h7-8H,2-4H2,1H3,(H,9,10)2,2-Bis(hydroxymethyl)butyric acid2,2'-Bis(hydroxymethyl)butyric acid2,2-bis(hydroxymethyl)-n-butyric acidDimethylol butanoic acidButanoic acid, bis(hydroxymethyl)-2,2-dihydroxymethylbutyric acid2,2-bis-(Hydroxymethyl)-n-buty2,2-Bis(hydroxymethyl)butyricacid

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID8064939
PubMed:11262433

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match3301396

Attributed physical-property, hazard, environmental and use annotations.

Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P264+P265, P273, P280, P305+P354+P338, P317, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P264+P265, P273, P280, P305+P354+P338, P317, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 80 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H412 (98.3%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 60 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
GHS Hazard Statements: H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
Precautionary Statement Codes: P264+P265, P273, P280, P305+P354+P338, P317, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
EMBL-EBI ChEBI	No exact record	2026-08-31
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for DIMETHYLOLBUTYRIC ACID

INCI name

DIMETHYLOLBUTYRIC ACID

Description

2,2-Bis(hydroxymethyl)butyric acid

Record provenance

Inventory reference: 97152
Imported identity: DIMETHYLOLBUTYRIC ACID
Source update: 15/04/2019

European Commission CosIng source notes

Annex records for DIMETHYLOLBUTYRIC ACID

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Key data

CAS

10097-02-6

424-090-1, 600-143-4

Restriction

—

Function

NOT REPORTED: No function currently reported.

Ingredients with overlapping formulation functions

DIMETHYLACRYLAMIDENOT REPORTED

DIMETHYLAMINOPROPYL METHACRYLAMIDENOT REPORTED

DIMETHYLAMINOPROPYLACRYLAMIDENOT REPORTED

DIMETHYLAMINOPROPYLAMINENOT REPORTED

DIMETHYLOLPROPIONIC ACIDNOT REPORTED

DIOSCOREA COMMUNIS ROOT EXTRACTNOT REPORTED

DIPEPTIDE-41NOT REPORTED

DIPEPTIDE-42NOT REPORTED

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How DIMETHYLOLBUTYRIC ACID appears in the CosIng inventory

The CosIng inventory lists DIMETHYLOLBUTYRIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DIMETHYLOLBUTYRIC ACID is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DIMETHYLOLBUTYRIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, DIMETHYLOLBUTYRIC ACID carries the following function designation(s):

NOT REPORTED

CAS 10097-02-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for DIMETHYLOLBUTYRIC ACID

This page reproduces the CosIng inventory entry for DIMETHYLOLBUTYRIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research DIMETHYLOLBUTYRIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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