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CAS 172208-34-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 9680226/04/2019

TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE

Spiro[2H-indole-2,3'-[3H]naphth[2,1-b][1,4]oxazine], 1,3-dihydro-1,3,3-trimethyl-6'-(1-piperidinyl)-6-(trifluoromethyl)-

TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 172208-34-3

CAS 172208-34-3PubChem CID 67392949

1',3',3'-Trimethyl-6-piperidin-1-yl-6'-(trifluoromethyl)spiro[benzo[f][1,4]benzoxazine-3,2'-indole]

IUPAC name: 1',3',3'-trimethyl-6-piperidin-1-yl-6'-(trifluoromethyl)spiro[benzo[f][1,4]benzoxazine-3,2'-indole]

Molecular formula: C28H28F3N3O
Molecular weight: 479.5 g/mol
Exact mass: 479.21844701 Da
XLogP3: 6.9
Topological polar surface area: 28.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 7
Covalent units: 1
Defined stereocentres: 0

Also known as

ICAOQPRXCZFWTM-UHFFFAOYSA-N1,3-Dihydro-1,3,3-trimethyl-6a(2)-(1-piperidinyl)-6-(trifluoromethyl)spiro[2H-indole-2,3a(2)-[3H]naphth[2,1-b][1,4]oxazine]

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External database identifiers

EPA DTXSID:DTXSID001105813

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE

INCI name

TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE

Description

Spiro[2H-indole-2,3'-[3H]naphth[2,1-b][1,4]oxazine], 1,3-dihydro-1,3,3-trimethyl-6'-(1-piperidinyl)-6-(trifluoromethyl)-

Record provenance

Inventory reference: 96802
Imported identity: TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE
Source update: 26/04/2019

European Commission CosIng source notes

Annex records for TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE

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Key data

CAS

172208-34-3

—

Restriction

—

Function

COLORANT: Exclusively or mainly intended to colour the cosmetic product, the body as a whole or certain parts thereof, by absorption or reflection of visible light. All authorised colorants are substances in the positive list of Annex IV to the Cosmetics Regulation 1223/2009.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#29264 · TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE

Ingredients with overlapping formulation functions

TITANIUM DIOXIDECOLORANT, OPACIFYING, UV ABSORBER, UV FILTER

TITANIUM/TITANIUM DIOXIDECOLORANT, OPACIFYING

TOURMALINE POWDERBULKING, COLORANT

TRIETHYLAMINE HEXYLSALICYLATECOLORANT

TRIMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINECOLORANT

TRISODIUM COPPER CHLORIN E6COLORANT

VIOLACEINANTIMICROBIAL, ANTIOXIDANT, COLORANT

WINE LEES EXTRACTCOLORANT; HAIR CONDITIONING; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE appears in the CosIng inventory

The CosIng inventory lists TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE carries the following function designation(s):

COLORANT

CAS 172208-34-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE

This page reproduces the CosIng inventory entry for TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TRIMETHYL TRIFLUOROMETHYLINDOLINO PIPERIDINYLSPIRONAPHTHOOXAZINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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