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CAS 116499-21-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 9657513/05/2019

HYDROXYMETHYL PREGNACALCIFEROL

Decarboxy Calcioic Alcohol, 1H-Indene-1-ethanol, octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-\b.,7a-dimethyl-, (\b.S,1R,3aS,4E,7aR)-

HYDROXYMETHYL PREGNACALCIFEROL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 116499-21-9

CAS 116499-21-9PubChem CID 9547270

(5Z,7E)-(3S)-23,24-dinor-9,10-seco-5,7,10(19)-cholatrien-3,22-diol

(5Z,7E)-(3S)-23,24-dinor-9,10-seco-5,7,10(19)-cholatrien-3,22-diol is a vitamin D. — ChEBI

IUPAC name: (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(2S)-1-hydroxypropan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol

Molecular formula: C22H34O2
Molecular weight: 330.5 g/mol
Exact mass: 330.255880323 Da
XLogP3: 4.3
Topological polar surface area: 40.5 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 5

Also known as

22-Hydroxy-23,24,25,26,27-pentanorcholecalciferolCHEBI:17305622-hydroxy-23,24,25,26,27-pentanorvitamin D3(betaS,1R,3aS,4E,7aR)-Octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-beta,7a-dimethyl-1H-indene-1-ethanol22-hydroxy-23,24,25,26,27-pentanorvitamin D3 / 22-hydroxy-23,24,25,26,27-pentanorcholecalciferol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:173056
ChEMBL:CHEMBL2063147
PubMed:8590938

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match9547270

Attributed physical-property, hazard, environmental and use annotations.

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for HYDROXYMETHYL PREGNACALCIFEROL

INCI name

HYDROXYMETHYL PREGNACALCIFEROL

Description

Decarboxy Calcioic Alcohol, 1H-Indene-1-ethanol, octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-\b.,7a-dimethyl-, (\b.S,1R,3aS,4E,7aR)-

Record provenance

Inventory reference: 96575
Imported identity: HYDROXYMETHYL PREGNACALCIFEROL
Source update: 13/05/2019

European Commission CosIng source notes

Annex records for HYDROXYMETHYL PREGNACALCIFEROL

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Key data

CAS

116499-21-9

—

Restriction

—

Function

HUMECTANT: Retaining and/or preserving the moisture in a product during use.
SKIN CONDITIONING: Maintaining the skin in good condition.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#13310 · HYDROXYMETHYL PREGNACALCIFEROL

Ingredients with overlapping formulation functions

HYDROXYETHYL UREAHAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING

HYDROXYETHYLCELLULOSE/PHOSPHORYLCHOLINE GLYCOL ACRYLATE COPOLYMERFILM FORMING, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING

HYDROXYISOLEUCINEHUMECTANT, SKIN CONDITIONING

HYDROXYLATED 2-OCTANOLHUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

HYDROXYPROPYL BIS-HYDROXYETHYLDIMONIUM CHLORIDEHUMECTANT, SKIN CONDITIONING

HYDROXYPROPYL OXIDIZED STARCH PG-TRIMONIUM CHLORIDEFILM FORMING, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING

HYDROXYPROPYL TRIMONIUM CORN/WHEAT/SOY AMINO ACIDSHUMECTANT, SKIN CONDITIONING

HYDROXYPROPYLAMMONIUM GLUCONATEHAIR CONDITIONING, HUMECTANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How HYDROXYMETHYL PREGNACALCIFEROL appears in the CosIng inventory

The CosIng inventory lists HYDROXYMETHYL PREGNACALCIFEROL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HYDROXYMETHYL PREGNACALCIFEROL is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HYDROXYMETHYL PREGNACALCIFEROL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, HYDROXYMETHYL PREGNACALCIFEROL carries the following function designation(s):

CAS 116499-21-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for HYDROXYMETHYL PREGNACALCIFEROL

This page reproduces the CosIng inventory entry for HYDROXYMETHYL PREGNACALCIFEROL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research HYDROXYMETHYL PREGNACALCIFEROL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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