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InventoryRef 9580124/04/2018

CIS-RETINOIC ACID

Accutane,Isotretinoin (INN),Retinoic acid, 13-cis-,13-cis-Vitamin A acid

CIS-RETINOIC ACID is linked to 1 EU annex record on this page. Inventory note: II/375.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionEvidence linked
Prohibited entry found
Open this evidence		1English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandSource mapped
Official source mapped; ingredient rule not imported
0English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 4759-48-2
CAS 4759-48-2PubChem CID 5282379

Isotretinoin

Isotretinoin is a retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases. It has a role as an antineoplastic agent, a keratolytic drug and a teratogenic agent. It is a conjugate acid of a 13-cis-retinoate. — ChEBI

IUPAC name
(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
Molecular formula
C20H28O2
Molecular weight
300.4 g/mol
Exact mass
300.208930132 Da
XLogP3
6.3
Topological polar surface area
37.3 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

13-cis-Retinoic acidAccutane13-cis-Vitamin A acidNeovitamin A acidClaravisRoaccutane13-cis retinoic acidAmnesteem
16 more reported names
IsotrexSotretIsotretinoineRoaccutanTeriosalisotretinoinoIsotretinoinumAbsorica13-RARoacutanRETINOIC ACID, 13-cis-Ro-4-3780isotretinoinaMyorisanZenataneRo 4-3780
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CIS-RETINOIC ACID

INCI name

CIS-RETINOIC ACID

Description

Accutane,Isotretinoin (INN),Retinoic acid, 13-cis-,13-cis-Vitamin A acid

Record provenance

Inventory reference
95801
Imported identity
CIS-RETINOIC ACID
Source update
24/04/2018
European Commission CosIng source notes

Key data

CAS
4759-48-2
EC
225-296-0
Restriction
II/375
Function
ANTI-SEBUM
Helping control sebum production.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#6584 · CIS-RETINOIC ACID

Ingredients with overlapping formulation functions

CINNAMOMUM CASSIA BARK WATERANTI-SEBUM, ANTIMICROBIAL, ASTRINGENT
CINNAMOMUM CASSIA BARK/SYZGIUM AROMATICUM BUD/ROSMARINUS OFFICINALIS LEAF/THYMU…ANTI-SEBUM, ANTIMICROBIAL, ANTIOXIDANT, ANTIPLAQUE
CINNAMOMUM CASSIA BARK/SYZGIUM AROMATICUM BUD/ROSMARINUS OFFICINALIS LEAF/THYMU…ANTI-SEBUM, ANTIMICROBIAL, ANTIOXIDANT, ANTIPLAQUE
CINNAMOMUM CASSIA BRANCH/HONEYSUCKLE FLOWER/(ARCTIUM LAPPA/SCHISANDRA CHINENSIS…ANTI-SEBUM, ANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT
CITRUS HYSTRIX LEAF WATERANTI-SEBUM, ANTIOXIDANT, ASTRINGENT, FRAGRANCE, SKIN CONDITIONING
CLEOME GYNANDRA LEAF EXTRACTANTI-SEBUM
COCCOMYXA SP. KJ EXTRACTANTIMICROBIAL; ANTI-SEBUM; ORAL CARE
COMMIPHORA TENUIPETIOLATA GUM EXTRACTANTI-SEBUM, ANTIMICROBIAL

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How CIS-RETINOIC ACID appears in the CosIng inventory

The CosIng inventory lists CIS-RETINOIC ACID as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CIS-RETINOIC ACID is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CIS-RETINOIC ACID appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for CIS-RETINOIC ACID reads: "II/375". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, CIS-RETINOIC ACID carries the following function designation(s):

CAS 4759-48-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for CIS-RETINOIC ACID

This page combines the CosIng inventory entry for CIS-RETINOIC ACID with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research CIS-RETINOIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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