Is BIS-METHANE safe to use in EU cosmetics?

BIS-METHANE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 474510-57-1?

CAS 474510-57-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains BIS-METHANE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9573823/04/2018

BIS-METHANE

1-Propanone, 1,1'-(methylene-di-4,1-phenylene)bis[2-hydroxy-2-methyl-

BIS-METHANE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 474510-57-1

CAS 474510-57-1PubChem CID 22019754

Bis(4-(2-hydroxy-2-methylpropionyl)phenyl)methane

IUPAC name: 2-hydroxy-1-[4-[[4-(2-hydroxy-2-methylpropanoyl)phenyl]methyl]phenyl]-2-methylpropan-1-one

Molecular formula: C21H24O4
Molecular weight: 340.4 g/mol
Exact mass: 340.16745924 Da
XLogP3: 3.1
Topological polar surface area: 74.6 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

Irgacure 127IZJ9BVRDO72-Hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl)-2-methylpropan-1-oneEC 444-860-91-Propanone, 1,1'-(methylene-di-4,1-phenylene)bis[2-hydroxy-2-methyl-1-PROPANONE, 1,1'-(METHYLENE-DI-4,1-PHENYLENE)BIS(2-HYDROXY-2-METHYL-Bis[4-(2-hydroxy-2-methylpropionyl)phenyl]methaneRefChem:568870

16 more reported names

444-860-91,1'-(Methylene-di-4,1-phenylene)bis[2-hydroxy-2-methyl-1-propanone]1,1'-(Methylenebis(4,1-phenylene))bis(2-hydroxy-2-methylpropan-1-one)1,1'-[Methylenebis(4,1-phenylene)]bis(2-hydroxy-2-methyl-1-propanone)1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one)Photoinitiator127Photoinitiator 127photoinitiator??127UNII-IZJ9BVRDO7AC9236BS-514931,1?-[METHYLENEBIS(4,1-PHENYLENE)]BIS(2-HYDROXY-2-METHYL-1-PROPANONE)2-hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)-benzyl)-phenyl)-2-methylpropan-1-one2-Hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl)- 2-methylpropan-1-one2-hydroxy-1-{4-[4(2-hydroxy-2-methyl-propionyl)-benzyl]-phenyl}-2-methyl-propan-1-one2-hydroxy-1-{4-[4-(2-hydroxy-2-methyl-propionyl)-benzyl]phenyl}-2-methyl-propane-1-one

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID40621591

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for BIS-METHANE

INCI name

BIS-METHANE

Description

1-Propanone, 1,1'-(methylene-di-4,1-phenylene)bis[2-hydroxy-2-methyl-

Record provenance

Inventory reference: 95738
Imported identity: BIS-METHANE
Source update: 23/04/2018

European Commission CosIng source notes

Annex records for BIS-METHANE

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Key data

CAS

474510-57-1

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Restriction

—

Function

UV FILTER: Exclusively or mainly intended to protect the skin and/or hair against certain UV radiation by absorbing, reflecting or scattering UV radiation. All authorised UV filters are substances in the positive list of Annex VI to the Cosmetics Regulation 1223/2009.

Ingredients with overlapping formulation functions

BENZOPHENONE-5LIGHT STABILIZER, UV ABSORBER, UV FILTER

BENZYLIDENE CAMPHOR SULFONIC ACIDLIGHT STABILIZER, UV ABSORBER, UV FILTER

BIS-(DIETHYLAMINOHYDROXYBENZOYL BENZOYL) PIPERAZINEUV FILTER

BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINEHAIR CONDITIONING, LIGHT STABILIZER, UV ABSORBER, UV FILTER

BIS-PABA PORPHYRA 334ANTIOXIDANT, LIGHT STABILIZER, UV FILTER

BIS-SH-DECAPEPTIDE-9 PORPHYRA 334ANTIOXIDANT, LIGHT STABILIZER, UV FILTER

BIS-SH-PENTAPEPTIDE-38 PORPHYRA 334ANTIOXIDANT, LIGHT STABILIZER, UV FILTER

BIS-SH-PENTAPEPTIDE-5 PORPHYRA 334ANTIOXIDANT, LIGHT STABILIZER, UV FILTER

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How BIS-METHANE appears in the CosIng inventory

The CosIng inventory lists BIS-METHANE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

BIS-METHANE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

BIS-METHANE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, BIS-METHANE carries the following function designation(s):

UV FILTER

CAS 474510-57-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for BIS-METHANE

This page reproduces the CosIng inventory entry for BIS-METHANE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research BIS-METHANE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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