Is LEVISTOLIDE A safe to use in EU cosmetics?

LEVISTOLIDE A is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 88182-33-6?

CAS 88182-33-6 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains LEVISTOLIDE A?

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InventoryRef 9461717/08/2016

LEVISTOLIDE A

1H-5,10c-Ethanonaphtho[1,2-c:7,8-c']difuran-3,10-dione, 1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-, (1Z,5S,5aS,8Z,10bS,10cS)-

LEVISTOLIDE A is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 88182-33-6

CAS 88182-33-6PubChem CID 70698035

Levistolide A

(Z)-6,6',7,3'a-Diligustilide is a butenolide. It has a role as a metabolite. — ChEBI

IUPAC name: (1S,2S,6Z,10S,11S,16Z)-6,16-di(butylidene)-5,15-dioxapentacyclo[9.5.2.01,13.02,10.03,7]octadeca-3(7),12-diene-4,14-dione

Molecular formula: C24H28O4
Molecular weight: 380.5 g/mol
Exact mass: 380.19875937 Da
XLogP3: 4.9
Topological polar surface area: 52.6 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 4

Also known as

Levistolid A(Z,Z)-DiligustilideZ,Z'-6,6',7,3'a-Diligustilide29MRT0H4CE1H-5,10c-Ethanonaphtho(1,2-c:7,8-c')difuran-3,10-dione, 1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-, (1Z,5S,5aS,8Z,10bS,10cs)-RefChem:41298(6Z,16Z)-6,16-dibutylidene-5,15-dioxapentacyclo(9.5.2.0^(1,13).0^(2,10).0^(3,7))octadeca-3(7),12-diene-4,14-dione1H-5,10c-Ethanonaphtho(1,2-c:7,8-c')difuran-3,10-dione, 1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-, (5S,8Z,10cS)-

16 more reported names

Levistilide ADiligustilideSenkyunolide O(1Z,5S,5aS,8Z,10bS,10cS)-1,8-Dibutylidene-5,5a,6,7,8,10b-hexahydro-1H-5,10c-ethanonaphtho[1,2-c:7,8-c']difuran-3,10-dioneUNII-29MRT0H4CElevistilideLevistilideALevistilide-AZ-levistolide AE,Z'-6,6',7,3'a-diligustilide(Z,Z)-di(butylidene)[?]dioneCHEBI:68231GLXC-05768(1Z,5S,5aS,8Z,10bS,10cS)-1,8-Dibutylidene-5,5a,6,7-tetrahydro-1H-5,10c-ethanonaphtho[1,2-c:7,8-c']difuran-3,10(8H,10bH)-dioneHY-N1472(Z)-6,6',7,3'a-Diligustilide

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:68231
EPA DTXSID:DTXSID601317628
PubMed:30496664
PubMed:18358092
PubMed:17520522

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for LEVISTOLIDE A

INCI name

LEVISTOLIDE A

Description

1H-5,10c-Ethanonaphtho[1,2-c:7,8-c']difuran-3,10-dione, 1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-, (1Z,5S,5aS,8Z,10bS,10cS)-

Record provenance

Inventory reference: 94617
Imported identity: LEVISTOLIDE A
Source update: 17/08/2016

European Commission CosIng source notes

Annex records for LEVISTOLIDE A

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Key data

CAS

88182-33-6

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#15309 · LEVISTOLIDE A

Ingredients with overlapping formulation functions

LESPEDEZA CYRTOBOTRYA EXTRACTANTIFOAMING, ANTIMICROBIAL, ANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

LESSONIA NIGRESCENS EXTRACTSKIN PROTECTING

LEUCOJUM AESTIVUM BULB EXTRACTSKIN PROTECTING

LEVANFILM FORMING, SKIN PROTECTING

LIGNANSSKIN PROTECTING

LILIUM CANDIDUM CALLUS CULTURE EXTRACTANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING

LILIUM LONGIFLORUM BULB EXTRACTASTRINGENT, SKIN CONDITIONING, SKIN PROTECTING

LIMNANTHES ALBA SEED OIL ETHYL ESTERSSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How LEVISTOLIDE A appears in the CosIng inventory

The CosIng inventory lists LEVISTOLIDE A as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

LEVISTOLIDE A is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

LEVISTOLIDE A is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, LEVISTOLIDE A carries the following function designation(s):

CAS 88182-33-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for LEVISTOLIDE A

This page reproduces the CosIng inventory entry for LEVISTOLIDE A from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research LEVISTOLIDE A and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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