Is SOPHOCARPINE safe to use in EU cosmetics?

SOPHOCARPINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 6483-15-4?

CAS 6483-15-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains SOPHOCARPINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9436505/09/2016

SOPHOCARPINE

1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, (7aS,13aR,13bR,13cS)-

SOPHOCARPINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 6483-15-4

CAS 6483-15-4PubChem CID 115269

(-)-Sophocarpine

(−)-sophocarpine has been reported in Daphniphyllum oldhamii, Daphniphyllum pentandrum, and other organisms with data available. — LOTUS - the natural products occurrence database

IUPAC name: (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadec-4-en-6-one

Molecular formula: C15H22N2O
Molecular weight: 246.35 g/mol
Exact mass: 246.173213330 Da
XLogP3: 1.7
Topological polar surface area: 23.6 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 4

Also known as

SophocarpineMatridin-15-one, 13,14-didehydro-X9X8U6P2NP1H,5H,10H-Dipyrido(2,1-f:3',2',1'-ij)(1,6)naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, (7aS,13aR,13bR,13cS)-13,14-didehydro-matridin-15-one1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, (7aS,13aR,13bR,13cS)-(1R,2R,9S,17S)-7,13-diazatetracyclo(7.7.1.02,7.013,17)heptadec-4-en-6-oneRefChem:184339

16 more reported names

13,14-Didehydromatridin-15-oneSophoridine hydrate13,14-DidehydromatrineSophocarpine MonohydrateC15H22N2OSophocarpine (monohydrate)(41S,7aS,13aR,13bR)-2,3,41,6,7,7a,8,13,13a,13b-Decahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one13,14-Dehydromatrine(-)-sophocarpin(-)-Sophocarpine; 13,14-Dehydromatrine; 13,14-Didehydromatrine; 13,14-Didehydro-matridin-15-oneSophocarpine (Standard)(41S,7aS,13aR,13bR)-2,3,5,6,7,7a,8,13,13a,13b-decahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(41H)-one1H,5H,10H-DipyrHY-N0103RSophocarpine - Bio-X trade markAAGFPTSOPGCENQ-JLNYLFASSA-N

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:228910
ChEMBL:CHEMBL377725
EPA DTXSID:DTXSID90215126
PubMed:11933118

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for SOPHOCARPINE

INCI name

SOPHOCARPINE

Description

1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, (7aS,13aR,13bR,13cS)-

Record provenance

Inventory reference: 94365
Imported identity: SOPHOCARPINE
Source update: 05/09/2016

European Commission CosIng source notes

Annex records for SOPHOCARPINE

Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search annex entries

Search the annex database for entries matching SOPHOCARPINE or related substances.

Key data

CAS

6483-15-4

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#27227 · SOPHOCARPINE

Ingredients with overlapping formulation functions

SOLUBLE ELASTINSKIN CONDITIONING

SOLUBLE PROTEOGLYCANHAIR CONDITIONING, SKIN CONDITIONING

SONCHUS OLERACEUS EXTRACTSKIN CONDITIONING

SONCHUS OLERACEUS JUICE EXTRACTSKIN CONDITIONING

SOPHORA ANGUSTIFOLIA ROOT EXTRACTSKIN CONDITIONING

SOPHORA FLAVESCENS EXTRACTSKIN CONDITIONING

SOPHORA FLAVESCENS ROOT EXTRACTANTIOXIDANT, SKIN CONDITIONING

SOPHORA JAPONICA BRANCH EXTRACTSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SOPHOCARPINE appears in the CosIng inventory

The CosIng inventory lists SOPHOCARPINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SOPHOCARPINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SOPHOCARPINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SOPHOCARPINE carries the following function designation(s):

SKIN CONDITIONING

CAS 6483-15-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for SOPHOCARPINE

This page reproduces the CosIng inventory entry for SOPHOCARPINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SOPHOCARPINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect SOPHOCARPINE and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to SOPHOCARPINE, its identifiers or nearby name variants.