Is HARPAGIDE safe to use in EU cosmetics?

HARPAGIDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 6926-08-5?

CAS 6926-08-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains HARPAGIDE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9203502/10/2014

HARPAGIDE

\b-D-Glucopyranoside,(1S,4aS,5R,7S,7aR)-1,4a,5,6,7,7a-hexahydro-4a,5,7-trihydroxy-7-methylcyclopenta[c]pyran-1-yl

HARPAGIDE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 6926-08-5

CAS 6926-08-5PubChem CID 93045

Harpagide

harpagide has been reported in Caryopteris incana, Scrophularia buergeriana, and other organisms with data available. — LOTUS - the natural products occurrence database

IUPAC name: (1S,4aS,5R,7S,7aR)-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-4a,5,7-triol

Molecular formula: C15H24O10
Molecular weight: 364.34 g/mol
Exact mass: 364.13694696 Da
XLogP3: -3.3
Topological polar surface area: 169.0 Å²
Hydrogen-bond donors: 7
Hydrogen-bond acceptors: 10
Covalent units: 1
Defined stereocentres: 10

Also known as

OF59XHX7SR(1S,4aS,5R,7S,7aR)-7-methyl-1-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy-1,5,6,7a-tetrahydrocyclopenta(c)pyran-4a,5,7-triolRefChem:37991230-050-0Harpagide (90%)EINECS 230-050-0Harpagide (Standard)Cefaclor Impurity 124

11 more reported names

UNII-OF59XHX7SRHY-N0397RHY-N0397CCG-268210EBC-618089(2S,3R,4S,5S,6R)-2-{[(1S,4aS,5R,7S,7aR)-4a,5,7-trihydroxy-7-methyl-1H,4aH,5H,6H,7H,7aH-cyclopenta[c]pyran-1-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triolAC-34269CS-0008932(1S,4aS,5R,7S,7aR)-4a,5,7-Trihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-1-yl beta-D-glucopyranoside(1S-(1A,4AA,5A,7A,7A))-1,4A,5,6,7,7A-HEXAHYDRO-4A,5,7-TRIHYDROXY-7-METHYLCYCLOPENTA(C)PYRAN-1-YL BETA-D-GLUCOPYRANOSIDE(1S-(1alpha,4aalpha,5alpha,7alpha,7aalpha))-1,4a,5,6,7,7a-Hexahydro-4a,5,7-trihydroxy-7-methylcyclopenta(c)pyran-1-yl beta-D-glucopyranoside

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL464889
EPA DTXSID:DTXSID30988983

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for HARPAGIDE

INCI name

HARPAGIDE

Description

\b-D-Glucopyranoside,(1S,4aS,5R,7S,7aR)-1,4a,5,6,7,7a-hexahydro-4a,5,7-trihydroxy-7-methylcyclopenta[c]pyran-1-yl

Record provenance

Inventory reference: 92035
Imported identity: HARPAGIDE
Source update: 02/10/2014

European Commission CosIng source notes

Annex records for HARPAGIDE

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Key data

CAS

6926-08-5

230-050-0

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#11557 · HARPAGIDE

Ingredients with overlapping formulation functions

HABERLEA RHODOPENSIS CALLUS EXTRACTANTIMICROBIAL, ANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

HAHELLA CHEJUENSIS FERMENT FILTRATE EXTRACTANTI-SEBUM; COLORANT; SKIN PROTECTING; SKIN CONDITIONING - MISCELLANEOUS

HALOCIDIN SUBUNIT A AMIDE/HALOCIDIN SUBUNIT B AMIDESKIN PROTECTING

HANSENULA/KLOECKERA/LACTOBACILLUS/LACTOCOCCUS/LEUCONOSTOC/PEDIOCOCCUS/SACCHAROM…SKIN CONDITIONING, SKIN PROTECTING

HEDERA RHOMBEA EXTRACTHUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

HEDYCHIUM CORONARIUM FLOWER WATERANTIOXIDANT; SKIN CONDITIONING - EMOLLIENT; SKIN PROTECTING

HELIANTHEMUM NUMMULARIUM FLOWER EXTRACTSKIN PROTECTING

HELIANTHUS ANNUUS SEED OIL EXTRACTANTIOXIDANT; PRESERVATIVE; SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How HARPAGIDE appears in the CosIng inventory

The CosIng inventory lists HARPAGIDE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HARPAGIDE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HARPAGIDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, HARPAGIDE carries the following function designation(s):

CAS 6926-08-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for HARPAGIDE

This page reproduces the CosIng inventory entry for HARPAGIDE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research HARPAGIDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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