Is ARCTIIN safe to use in EU cosmetics?

ARCTIIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

How do I check if my formula contains ARCTIIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9008028/05/2013

ARCTIIN

Arctigenin-4-glucoside,2(3H)-Furanone, 4-[(3,4-dimethoxyphenyl)methyl]-3-[[(4-(\b-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-, (3R,4R)-

ARCTIIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 20362-31-6

CAS 20362-31-6PubChem CID 100528

Arctiin

Arctiin is a glycoside and a lignan. — ChEBI

IUPAC name: (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[[3-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl]oxolan-2-one

Molecular formula: C27H34O11
Molecular weight: 534.6 g/mol
Exact mass: 534.21011190 Da
XLogP3: 1.8
Topological polar surface area: 153.0 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 11
Covalent units: 1
Defined stereocentres: 7

Also known as

Arctigenin-4-glucosideTM5RQ949K7NSC-315527(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-{[3-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl}oxolan-2-one2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)-3-((4-(beta-D-glucopyranosyloxy)-3-methoxyphenyl)methyl)dihydro-, (3R-trans)-(3R,4R)-4-((3,4-dimethoxyphenyl)methyl)-3-((3-methoxy-4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxyphenyl)methyl)oxolan-2-oneRefChem:28095(-)-Arctiin

16 more reported names

CHEBI:807932(3H)-Furanone, 4-[(3,4-dimethoxyphenyl)methyl]-3-[[4-(beta-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-, (3R,4R)-(3R,4R)-4-(3,4-Dimethoxybenzyl)-3-(3-methoxy-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzyl)dihydrofuran-2(3H)-oneArctiiBRD-K02568760-001-01-72(3H)-FURANONE, 4-((3,4-DIMETHOXYPHENYL)METHYL)-3-((4-(.BETA.-D-GLUCOPYRANOSYLOXY)-3-METHOXYPHENYL)METHYL)DIHYDRO-, (3R,4R)-NSC 315527UNII-TM5RQ949K7CCRIS 8412XOJVHLIYNSOZOO-SWOBOCGESA-NArctii;NSC 315527;Arctigenin-4-glucosideArctiin(NSC 315527)?MEGxp0_000527ACon1_001261Arctiin, >=95% (LC/MS-ELSD)CCG-269936

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:80793
ChEMBL:CHEMBL388452
EPA DTXSID:DTXSID20942519
PubMed:26141518
PubMed:23691032
PubMed:22753037
PubMed:22499560
PubMed:22466563
PubMed:22445988
PubMed:22363569
PubMed:22296876
PubMed:22203879
PubMed:22016962
PubMed:21887385
PubMed:21756341

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ARCTIIN

INCI name

ARCTIIN

Description

Arctigenin-4-glucoside,2(3H)-Furanone, 4-[(3,4-dimethoxyphenyl)methyl]-3-[[(4-(\b-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-, (3R,4R)-

Record provenance

Inventory reference: 90080
Imported identity: ARCTIIN
Source update: 28/05/2013

European Commission CosIng source notes

Annex records for ARCTIIN

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Key data

CAS

20362-31-6 -1073499-63-4

—

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#2183 · ARCTIIN

Ingredients with overlapping formulation functions

ARBUTINYL UNDECYLENATEANTIMICROBIAL, ANTIOXIDANT, BLEACHING

ARBUTUS UNEDO FRUIT EXTRACTANTIOXIDANT, SKIN CONDITIONING

ARBUTUS UNEDO LEAF CELL EXTRACTANTIOXIDANT, SKIN PROTECTING

ARCTIGENINANTIOXIDANT

ARCTIUM LAPPA FRUIT EXTRACTANTIOXIDANT, SKIN CONDITIONING

ARGANIA SPINOSA CALLUS EXTRACTANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN PROTECTING

ARGEMONE MEXICANA CALLUS EXTRACTANTIOXIDANT

ARGININE AMINOPHOSPHONOBUTYRIC ACIDANTIOXIDANT, ANTIPLAQUE, HAIR CONDITIONING, NAIL CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ARCTIIN appears in the CosIng inventory

The CosIng inventory lists ARCTIIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ARCTIIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ARCTIIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ARCTIIN carries the following function designation(s):

ANTIOXIDANT

CAS 20362-31-6 -1073499-63-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for ARCTIIN

This page reproduces the CosIng inventory entry for ARCTIIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ARCTIIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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