Is HORDENINE safe to use in EU cosmetics?

HORDENINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 539-15-1?

CAS 539-15-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains HORDENINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8975720/12/2012

HORDENINE

Hordenine is the organic compound

HORDENINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 539-15-1

CAS 539-15-1PubChem CID 68313

Hordenine

Hordenine is a phenethylamine alkaloid. It has a role as a mouse metabolite and a human metabolite. — ChEBI

IUPAC name: 4-[2-(dimethylamino)ethyl]phenol

Molecular formula: C10H15NO
Molecular weight: 165.23 g/mol
Exact mass: 165.115364102 Da
XLogP3: 2.1
Topological polar surface area: 23.5 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

4-(2-(Dimethylamino)ethyl)phenolAnhalineN,N-Dimethyltyramine4-(2-Dimethylaminoethyl)phenolPeyocactineAnhalinCactineEremursine

16 more reported names

Ordeninap-(2-Dimethylaminoethyl)phenolK3489CA082CHEBI:5764N,N-Dimethyl-4-hydroxy-beta-phenethylamineRefChem:38568208-710-4HordeninPhenol, 4-[2-(dimethylamino)ethyl]-Ordeninep-Hydroxy-N,N-dimethylphenethylamineOrdenina;PeyocactineHordenine (sulfate)N,N-Dimethyl-p-hydroxyphenethylaminep-[2-(Dimethylamino)ethyl]phenolPhenol, p-[2-(dimethylamino)ethyl]-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:5764
ChEMBL:CHEMBL505789
EPA DTXSID:DTXSID2046096
PubMed:22645486
PubMed:21969747
PubMed:21955645
PubMed:21461373
PubMed:21259423
PubMed:21174767
PubMed:20847890
PubMed:20702100
PubMed:20390105
PubMed:19413108
PubMed:19126213
PubMed:19126212

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for HORDENINE

INCI name

HORDENINE

Description

Hordenine is the organic compound

Record provenance

Inventory reference: 89757
Imported identity: HORDENINE
Source update: 20/12/2012

European Commission CosIng source notes

Annex records for HORDENINE

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Key data

CAS

539-15-1

—

Restriction

—

Function

SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#12119 · HORDENINE

Ingredients with overlapping formulation functions

HIPPOPHAE RHAMNOIDES CALLUS EXTRACTANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

HIPPOPHAE RHAMNOIDES FRUIT OILSKIN PROTECTING

HIPPOPHAE RHAMNOIDES SEED OILSKIN PROTECTING

HIZIKIA FUSIFORMIS WATERSKIN PROTECTING

HORDEUM DISTICHON EXTRACTSKIN PROTECTING

HORNET EXTRACTANTI-SEBUM, ANTIMICROBIAL, SKIN CONDITIONING, SKIN PROTECTING

HORNET VENOMANTI-SEBUM, ANTIMICROBIAL, SKIN CONDITIONING, SKIN PROTECTING

HOUSEFLY LARVA EXTRACTSKIN CONDITIONING - EMOLLIENT; SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How HORDENINE appears in the CosIng inventory

The CosIng inventory lists HORDENINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HORDENINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HORDENINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, HORDENINE carries the following function designation(s):

SKIN PROTECTING

CAS 539-15-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for HORDENINE

This page reproduces the CosIng inventory entry for HORDENINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research HORDENINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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