Is TULIPALIN A safe to use in EU cosmetics?

TULIPALIN A is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 547-65-9?

CAS 547-65-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains TULIPALIN A?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8741715/10/2010

TULIPALIN A

alpha-Methylene-gamma-butyrolactone

TULIPALIN A is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 547-65-9

CAS 547-65-9PubChem CID 68352

alpha-Methylene butyrolactone

Alpha-methylene gamma-butyrolactone is a butan-4-olide having a methylene group at the 3-position. It has a role as an anti-ulcer drug and a gastrointestinal drug. — ChEBI

IUPAC name: 3-methylideneoxolan-2-one

Molecular formula: C5H6O2
Molecular weight: 98.10 g/mol
Exact mass: 98.036779430 Da
XLogP3: 0.8
Topological polar surface area: 26.3 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

alpha-Methylene-gamma-butyrolactoneTulipalin A3-Methylenedihydro-2(3H)-furanone3-methylenedihydrofuran-2(3H)-one2(3H)-Furanone, dihydro-3-methylene-Dihydro-3-methylene-2(3H)-furanoneSecurolidealpha-methylene gamma-butyrolactone

16 more reported names

.alpha.-Methylene butyrolactoneEINECS 208-931-6NSC 205367.alpha.-Methylene-.gamma.-butyrolactoneAI3-63021CHEBI:1041202-Methylenebutanolactone362Y256BOLTULIPALIN 98NSC-205367alpha-methylidene-gamma-butyrolactoneMETHYLENE BUTYROLACTONE, ALPHA-.ALPHA.-METHYLENE BUTYROLACTONE [MI]RefChem:555876TULIPALIN A [INCI]208-931-6

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:104120
ChEMBL:CHEMBL275748
EPA DTXSID:DTXSID2074663
PubMed:22734694
PubMed:22526727
PubMed:22247601
PubMed:22096324
PubMed:22070869
PubMed:21625597
PubMed:21620534
PubMed:21517115
PubMed:21488628
PubMed:20113426
PubMed:20026180
PubMed:19938025

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TULIPALIN A

INCI name

TULIPALIN A

Description

alpha-Methylene-gamma-butyrolactone

Record provenance

Inventory reference: 87417
Imported identity: TULIPALIN A
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for TULIPALIN A

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Key data

CAS

547-65-9

208-931-6

Restriction

—

Function

SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#29568 · TULIPALIN A

Ingredients with overlapping formulation functions

TRITICUM VULGARE SPROUT EXTRACTSKIN CONDITIONING, SKIN PROTECTING

TRONAANTIOXIDANT, SKIN PROTECTING

TSUGA CANADENSIS LEAF EXTRACTSKIN PROTECTING

TUBER AESTIVUM EXTRACTSKIN PROTECTING

TULIPALIN BSKIN PROTECTING

TURQUOISE POWDERSKIN PROTECTING

UBIQUINOLANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

ULMUS DAVIDIANA BARK EXTRACTHUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TULIPALIN A appears in the CosIng inventory

The CosIng inventory lists TULIPALIN A as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TULIPALIN A is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TULIPALIN A is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TULIPALIN A carries the following function designation(s):

SKIN PROTECTING

CAS 547-65-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TULIPALIN A

This page reproduces the CosIng inventory entry for TULIPALIN A from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TULIPALIN A and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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