Is SPIRAEOSIDE safe to use in EU cosmetics?

SPIRAEOSIDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 20229-56-5?

CAS 20229-56-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 8715713/11/2010

SPIRAEOSIDE

2-[4-(beta-D-glucopyranosyloxy)-3-hydroxyphenyl]-3,5,7-trihydroxy-4H-1-benzopyran-4-one

SPIRAEOSIDE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 20229-56-5

CAS 20229-56-5PubChem CID 5320844

Quercetin 4'-O-glucoside

Quercetin 4'-O-beta-D-glucopyranoside is a quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 4'. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a beta-D-glucoside, a member of flavonols, a tetrahydroxyflavone, a monosaccharide derivative and a quercetin O-glucoside. It is functionally related to a beta-D-glucose. It is a conjugate acid of a quercetin 4'-O-beta-D-glucopyranoside(1-). — ChEBI

IUPAC name: 3,5,7-trihydroxy-2-[3-hydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chromen-4-one

Molecular formula: C21H20O12
Molecular weight: 464.4 g/mol
Exact mass: 464.09547607 Da
XLogP3: 0.4
Topological polar surface area: 207.0 Å²
Hydrogen-bond donors: 8
Hydrogen-bond acceptors: 12
Covalent units: 1
Defined stereocentres: 5

Also known as

SpiraeosideQuercetin-4'-glucosideK2B74751XI4H-1-Benzopyran-4-one, 2-(4-(beta-D-glucopyranosyloxy)-3-hydroxyphenyl)-3,5,7-trihydroxy-4H-1-Benzopyran-4-one, 2-[4-(beta-D-glucopyranosyloxy)-3-hydroxyphenyl]-3,5,7-trihydroxy-3,5,7-trihydroxy-2-(3-hydroxy-4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxyphenyl)chromen-4-oneRefChem:504323,5,7-trihydroxy-2-(3-hydroxy-4-((2S,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxyphenyl)chromen-4-one

16 more reported names

243-614-6SpiraeinSpiraeosidSpireosideQuercetin 4'-glucosidequercetin 4'-O-beta-D-glucopyranosideSpiraein (Acacia)3,5,7-Trihydroxy-2-(3-hydroxy-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-4H-chromen-4-onequercetin-4'-o-glucosideEINECS 243-614-6Quercetin 4'-b-D-glucosideUNII-K2B74751XI4H-1-BENZOPYRAN-4-ONE, 2-(4-(.BETA.-D-GLUCOPYRANOSYLOXY)-3-HYDROXYPHENYL)-3,5,7-TRIHYDROXY-4H-1-Benzopyran-4-one, 2-[4-(.beta.-D-glucopyranosyloxy)-3-hydroxyphenyl]-3,5,7-trihydroxy-quercetin-4'-glycosidequercetin-4-O-glucoside

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:75839
ChEMBL:CHEMBL402947
EPA DTXSID:DTXSID00174078
PubMed:34116102
PubMed:32602595
PubMed:25294874
PubMed:23019902
PubMed:20707069
PubMed:20378972
PubMed:19894542
PubMed:18486637
PubMed:18454541
PubMed:18303842
PubMed:17495124
PubMed:15613018

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for SPIRAEOSIDE

INCI name

SPIRAEOSIDE

Description

2-[4-(beta-D-glucopyranosyloxy)-3-hydroxyphenyl]-3,5,7-trihydroxy-4H-1-benzopyran-4-one

Record provenance

Inventory reference: 87157
Imported identity: SPIRAEOSIDE
Source update: 13/11/2010

European Commission CosIng source notes

Annex records for SPIRAEOSIDE

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Key data

CAS

20229-56-5

243-614-6

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#27444 · SPIRAEOSIDE

Ingredients with overlapping formulation functions

SPIRAEA ULMARIA FLOWER EXTRACTSKIN CONDITIONING

SPIRAEA ULMARIA FLOWER WATERSKIN CONDITIONING

SPIRAEA ULMARIA LEAF EXTRACTSKIN CONDITIONING

SPIRAEA ULMARIA ROOT EXTRACTSKIN CONDITIONING

SPIRANTHES SINENSIS FLOWER/LEAF/STEM EXTRACTSKIN CONDITIONING

SPIRODELA POLYRHIZA EXTRACTSKIN CONDITIONING

SPIRULINA AMINO ACIDSHAIR CONDITIONING, SKIN CONDITIONING

SPLEEN EXTRACTSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SPIRAEOSIDE appears in the CosIng inventory

The CosIng inventory lists SPIRAEOSIDE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SPIRAEOSIDE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SPIRAEOSIDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SPIRAEOSIDE carries the following function designation(s):

SKIN CONDITIONING

CAS 20229-56-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for SPIRAEOSIDE

This page reproduces the CosIng inventory entry for SPIRAEOSIDE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SPIRAEOSIDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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