What does the restriction note for SPIRONOLACTONE mean?

The restriction field for SPIRONOLACTONE reads: II/4. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 52-01-7?

CAS 52-01-7 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains SPIRONOLACTONE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8710215/10/2010

SPIRONOLACTONE

17-alpha-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7-alpha-mercapto- 3-oxo-, gamma-lactone acetate

SPIRONOLACTONE is linked to 1 EU annex record on this page. Inventory note: II/4.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Prohibited Open this evidence	1	English
Canada	Evidence linked Prohibited Open this evidence	1	English and French
New Zealand	Evidence linked Prohibited Open this evidence	1	English
ASEAN	Evidence linked Prohibited Open this evidence	1	English and national languages
China	Evidence linked Prohibited Open this evidence	1	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Evidence linked Prohibited Open this evidence	1	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Evidence linked Prohibited Open this evidence	1	Portuguese with INCI crosswalks
India	Evidence linked Prohibited Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Prohibited Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 52-01-7

CAS 52-01-7PubChem CID 5833

Spironolactone

Spironolactone is a steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7. It has a role as a diuretic, an antihypertensive agent, a xenobiotic, an aldosterone antagonist and an environmental contaminant. It is a steroid lactone, an oxaspiro compound, a 3-oxo-Delta(4) steroid and a thioester. — ChEBI

IUPAC name: S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate

Molecular formula: C24H32O4S
Molecular weight: 416.6 g/mol
Exact mass: 416.20213067 Da
XLogP3: 2.9
Topological polar surface area: 85.7 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 7

Also known as

AldactoneVerospironeSpirolactoneSpiresisUractoneXenalonspironolattoneEspironolactona

16 more reported names

SpironolactonumAbbolactoneDiatensecLaractoneSC 9420SC-9420Spironolactone cevaCarospirSpireticNSC-15039927O7W4T232CHEBI:9241VeroshpironSC94203-(3-Keto-7-alpha-acetylthio-17-beta-hydroxy-4-androsten-17-alpha-yl)propionic acid lactone17alpha-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7alpha-mercapto-3-oxo-, gamma-lactone, acetate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:9241
ChEMBL:CHEMBL1393
EPA DTXSID:DTXSID6034186
PubMed:31065620
PubMed:28024992
PubMed:23116347
PubMed:23105506
PubMed:23077889
PubMed:23077888
PubMed:23077601
PubMed:23074496
PubMed:23074464
PubMed:23060371
PubMed:23035601
PubMed:23031616

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for SPIRONOLACTONE

INCI name

SPIRONOLACTONE

Description

17-alpha-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7-alpha-mercapto- 3-oxo-, gamma-lactone acetate

Record provenance

Inventory reference: 87102
Imported identity: SPIRONOLACTONE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for SPIRONOLACTONE

Annex II Restriction reference

Entry 4

Spironolactone (INN)

CAS: 52-01-7

EC: 200-133-6

Key data

CAS

52-01-7

200-133-6

Restriction

II/4

Function

NOT REPORTED: No function currently reported.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#27447 · SPIRONOLACTONE

Ingredients with overlapping formulation functions

SODIUM PERFLUOROHEXYL ETHYLPHOSPHONATENOT REPORTED

SODIUM PROPOXYHYDROXYPROPYL THIOSULFATE SILICANOT REPORTED

SOLANUM LYCOPERSICUM CALLUS CULTURE EXTRACTNOT REPORTED

SORBITOL POLYGLYCIDYL ETHERNOT REPORTED

SR-(METHIONYL SH-OLIGOPEPTIDE-75 SH-POLYPEPTIDE-85 HEXAPEPTIDE-40)NOT REPORTED

SR-DOLPHIN POLYPEPTIDE-1NOT REPORTED

SR-ELEPHANT POLYPEPTIDE-1NOT REPORTED

SR-ENTEROBACTERIA PHAGE T7 POLYPEPTIDE-1NOT REPORTED

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SPIRONOLACTONE appears in the CosIng inventory

The CosIng inventory lists SPIRONOLACTONE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SPIRONOLACTONE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SPIRONOLACTONE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for SPIRONOLACTONE reads: "II/4". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, SPIRONOLACTONE carries the following function designation(s):

NOT REPORTED

CAS 52-01-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for SPIRONOLACTONE

This page combines the CosIng inventory entry for SPIRONOLACTONE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research SPIRONOLACTONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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