Is PREGNADIENOL safe to use in EU cosmetics?

PREGNADIENOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 21321-88-0?

CAS 21321-88-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains PREGNADIENOL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8658313/11/2010

PREGNADIENOL

Pregna-5,20-dien-3-ol, (3beta)-

PREGNADIENOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 21321-88-0

CAS 21321-88-0PubChem CID 14263442

Pregnadienol

pregnadienol has been reported in Muricea californica and Eunicella cavolini with data available. — LOTUS - the natural products occurrence database

IUPAC name: (3S,8S,9S,10R,13R,14S,17R)-17-ethenyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

Molecular formula: C21H32O
Molecular weight: 300.5 g/mol
Exact mass: 300.245315640 Da
XLogP3: 5.6
Topological polar surface area: 20.2 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 7

Also known as

Muricin aglyconePregna-5,20-dien-3beta-ol5Y7P8234P5UNII-5Y7P8234P5Pregna-5,20-dien-3-ol, (3beta)-PREGNA-5,20-DIEN-3.BETA.-OLPREGNA-5,20-DIEN-3-OL, (3.BETA.)-(3S,8S,9S,10R,13R,14S,17R)-17-ethenyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-3-ol

3 more reported names

RefChem:175833PREGNADIENOL [INCI]AXSZNOPJKXHJAB-UZCUGSDUSA-N

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID70175597

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PREGNADIENOL

INCI name

PREGNADIENOL

Description

Pregna-5,20-dien-3-ol, (3beta)-

Record provenance

Inventory reference: 86583
Imported identity: PREGNADIENOL
Source update: 13/11/2010

European Commission CosIng source notes

Annex records for PREGNADIENOL

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Key data

CAS

21321-88-0

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Restriction

—

Function

FRAGRANCE: Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
PERFUMING: Used for perfume and aromatic raw materials.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#23236 · PREGNADIENOL

Ingredients with overlapping formulation functions

POTASSIUM ACESULFAMEFRAGRANCE

POTASSIUM GLYCYRRHETINATEFRAGRANCE, SKIN CONDITIONING

POTASSIUM PALMITOYL ASCORBYL GLUCOSIDEFRAGRANCE, HUMECTANT, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

POTASSIUM SORBATEFRAGRANCE, PRESERVATIVE

PROPIONIC ACIDANTIMICROBIAL, FRAGRANCE, pH ADJUSTERS, PRESERVATIVE

PROPYL BENZOATEFRAGRANCE, PRESERVATIVE

PROTIUM HEPTAPHYLLUM RESINBINDING, FRAGRANCE

PROTIUM HEPTAPHYLLUM RESIN EXTRACTFRAGRANCE

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PREGNADIENOL appears in the CosIng inventory

The CosIng inventory lists PREGNADIENOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PREGNADIENOL is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PREGNADIENOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PREGNADIENOL carries the following function designation(s):

CAS 21321-88-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PREGNADIENOL

This page reproduces the CosIng inventory entry for PREGNADIENOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PREGNADIENOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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