Is SALICIN safe to use in EU cosmetics?

SALICIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 138-52-3?

CAS 138-52-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8657615/10/2010

SALICIN

β-D-Glucopyranoside, 2-(hydroxymethyl)phenyl

SALICIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 138-52-3

CAS 138-52-3PubChem CID 439503

Salicin

Salicin is an aryl beta-D-glucoside that is salicyl alcohol in which the phenolic hydrogen has been replaced by a beta-D-glucosyl residue. It has a role as a metabolite, a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and a prodrug. It is a member of benzyl alcohols, an aryl beta-D-glucoside and an aromatic primary alcohol. It is functionally related to a salicyl alcohol. — ChEBI

IUPAC name: (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[2-(hydroxymethyl)phenoxy]oxane-3,4,5-triol

Molecular formula: C13H18O7
Molecular weight: 286.28 g/mol
Exact mass: 286.10525291 Da
XLogP3: -1.2
Topological polar surface area: 120.0 Å²
Hydrogen-bond donors: 5
Hydrogen-bond acceptors: 7
Covalent units: 1
Defined stereocentres: 5

Also known as

SalicosideD-(-)-SalicinSalicyl alcohol glucosideD(-)-Salicin2-(Hydroxymethyl)phenyl beta-D-glucopyranosideSaligenin beta-D-glucopyranoside2-(Hydroxymethyl)phenyl-beta-d-glucopyranosideSalicinum

16 more reported names

o-(Hydroxymethyl)phenyl beta-D-glucopyranosideNSC-5751CHEBI:17814(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(2-(hydroxymethyl)phenoxy)oxane-3,4,5-triolRefChem:884384Salicine(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(2-(hydroxymethyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triolD-SalicinSaligenin-beta-D-glucopyranosidealpha-Hydroxy-o-tolyl beta-D-glucopyranosideBenzyl alcohol, o-hydroxy-, o-glucosideAI3-19099Spectrum4_001058SDCCGMLS-0066698.P001B-D-Glucopyranoside, 2-(hydroxymethyl)phenylD-()-Salicin

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:17814
ChEMBL:CHEMBL462997
EPA DTXSID:DTXSID10883326
PubMed:23040386
PubMed:23021634
PubMed:23016273
PubMed:22850397
PubMed:22751668
PubMed:22743246
PubMed:22675588
PubMed:22649537
PubMed:22639641
PubMed:22606374
PubMed:22591976
PubMed:22568931

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for SALICIN

INCI name

SALICIN

Description

β-D-Glucopyranoside, 2-(hydroxymethyl)phenyl

Record provenance

Inventory reference: 86576
Imported identity: SALICIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for SALICIN

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Key data

CAS

138-52-3

205-331-6

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#25079 · SALICIN

Ingredients with overlapping formulation functions

SALACIA RETICULATA ROOT EXTRACTSKIN CONDITIONING

SALACIA RETICULATA ROOT/STEM POWDERSKIN CONDITIONING

SALACIA RETICULATA WOOD EXTRACTSKIN CONDITIONING

SALCOLINSKIN CONDITIONING, SKIN PROTECTING

SALICORNIA BIGELOVII EXTRACTSKIN CONDITIONING

SALICORNIA HERBACEA EXTRACTSKIN CONDITIONING

SALICYLIC ACIDANTI-SEBORRHEIC, FRAGRANCE, HAIR CONDITIONING, KERATOLYTIC, PRESERVATIVE, SKIN CONDITIONING

SALICYLOYL DECAPEPTIDE-10SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SALICIN appears in the CosIng inventory

The CosIng inventory lists SALICIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SALICIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SALICIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SALICIN carries the following function designation(s):

SKIN CONDITIONING

CAS 138-52-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for SALICIN

This page reproduces the CosIng inventory entry for SALICIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SALICIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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