Is MACELIGNAN safe to use in EU cosmetics?

MACELIGNAN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 107534-93-0?

CAS 107534-93-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains MACELIGNAN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8657115/10/2010

MACELIGNAN

MACELIGNAN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 107534-93-0

CAS 107534-93-0PubChem CID 10404245

Macelignan

4-[(2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxyphenol is a lignan. — ChEBI

IUPAC name: 4-[(2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxyphenol

Molecular formula: C20H24O4
Molecular weight: 328.4 g/mol
Exact mass: 328.16745924 Da
XLogP3: 5.2
Topological polar surface area: 47.9 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 2

Also known as

8PP3614Z43Phenol, 4-((2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl)-2-methoxy-(8R,8'S)-7-(3,4-methylenedioxyphenyl)-7'-(4-hydroxy-3-methoxyphenyl)-8,8'-dimethylbutaneRefChem:9251264-(4-(2H-1,3-benzodioxol-5-yl)-2,3-dimethylbutyl)-2-methoxyphenolANWULIGANAnwulignan(+)-Anwulignan

16 more reported names

austrobailignan 6UNII-8PP3614Z434-((2S,3R)-4-(benzo[d][1,3]dioxol-5-yl)-2,3-dimethylbutyl)-2-methoxyphenol(+)-Anwulignan;Anwuligan4-[(2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-dimethyl-butyl]-2-methoxy-phenolDL-anwulignans91464-[(2S,3R)-4-(Benzo[d][1,3]dioxol-5-yl)-2,3-dimethylbutyl]-2-methoxyphenolHMS2219A18Macelignan (Standard)Macelignan, >=98% (HPLC)CHEBI:94153HY-N0064Rcid_10404245QDDILOVMGWUNGD-UONOGXRCSA-NHMS3886J18

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:94153
ChEMBL:CHEMBL254071
EPA DTXSID:DTXSID00148077

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match10404245

Attributed physical-property, hazard, environmental and use annotations.

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
EMBL-EBI ChEBI	No exact record	2026-08-31
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for MACELIGNAN

INCI name

MACELIGNAN

Record provenance

Inventory reference: 86571
Imported identity: MACELIGNAN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for MACELIGNAN

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Key data

CAS

107534-93-0

—

Restriction

—

Function

ANTIMICROBIAL: Preventing and/or slowing down microbial growth.
ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
DEODORANT: Reducing and/or eliminating unpleasant odour. Contributing against the formation of malodour on body surfaces.
ORAL CARE: Providing cosmetic effects to the oral cavity, e.g. cleansing, deodorising, protecting.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#15725 · MACELIGNAN

Ingredients with overlapping formulation functions

LAURYLPYRIDINIUM CHLORIDEANTIMICROBIAL, ANTISTATIC, DEODORANT, SURFACTANT - CLEANSING

LAVANDULA ANGUSTIFOLIA FLOWER EXTRACTCLEANSING, DEODORANT, FRAGRANCE, REFRESHING, TONIC

LIMONENEDEODORANT, PERFUMING, SOLVENT

LINALOOLDEODORANT, PERFUMING

MAGNESIUM/ALUMINUM/ZINC/HYDROXIDE/CARBONATEANTI-SEBORRHEIC, DEODORANT

MENTHA PIPERITA EXTRACTCLEANSING, DEODORANT, FRAGRANCE, REFRESHING, TONIC

MENTHA PIPERITA WATERDEODORANT, FRAGRANCE, REFRESHING, TONIC

METHYL UNDECYLENATEDEODORANT, PERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How MACELIGNAN appears in the CosIng inventory

The CosIng inventory lists MACELIGNAN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

MACELIGNAN is also tagged with 4 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

MACELIGNAN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, MACELIGNAN carries the following function designation(s):

CAS 107534-93-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for MACELIGNAN

This page reproduces the CosIng inventory entry for MACELIGNAN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research MACELIGNAN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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