Is OVALICIN safe to use in EU cosmetics?

OVALICIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 19683-98-8?

CAS 19683-98-8 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 8541815/10/2010

OVALICIN

1-Oxaspiro(2,5)octan-6-one, 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-4-hydroxy-5-methoxy-, (1S,2R,3S,4R,5S)-(-)-

OVALICIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 19683-98-8

CAS 19683-98-8PubChem CID 10957430

(3S,4R,5S)-4-Hydroxy-5-methoxy-4-((2S,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl)-1-oxaspiro(2.5)octan-6-one

(3S,4R,5S)-4-hydroxy-5-methoxy-4-[(2S,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-one has been reported in Pseudeurotium ovale, Aspergillus fumigatus, and Sporothrix with data available. — LOTUS - the natural products occurrence database

IUPAC name: (3S,4R,5S)-4-hydroxy-5-methoxy-4-[(2S,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-one

Molecular formula: C16H24O5
Molecular weight: 296.36 g/mol
Exact mass: 296.16237386 Da
XLogP3: 0.6
Topological polar surface area: 71.6 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 5

Also known as

OvalicinXBF6GMZ9TW(3S,4R,5S)-4-hydroxy-5-methoxy-4-((2S,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro(2.5)octan-6-one(3S,4R,5S)-4-Hydroxy-5-methoxy-4-[(2S,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]octan-6-oneRefChem:208344(3S,4R,5S)-4-hydroxy-5-methoxy-4-((2S)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro(2.5)octan-6-oneGraphinone(-)-Ovalicin

9 more reported names

1-Oxaspiro(2,5)octan-6-one, 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-4-hydroxy-5-methoxy-, (1S,2R,3S,4R,5S)-(-)-UNII-XBF6GMZ9TW1-Oxaspiro[2.5]octan-6-one, 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-4-hydroxy-5-methoxy-, (1S,2R,3S,4R,5S)-(-)-HY-156959CS-0904954(3S,4R,5S)-4-Hydroxy-5-methoxy-4-((2S,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-one1-Oxaspiro[2.5]octan-6-one, 4-hydroxy-5-methoxy-4-[(2S,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-, (3S,4R,5S)-1-Oxaspiro[2.5]octan-6-one, 4-hydroxy-5-methoxy-4-[(2S,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-, (3S,4R,5S)-4-Hydroxy-5-methoxy-4-[(2S,3R)-2-methyl-3-(3-methyl-but-2-enyl)-oxiranyl]-1-oxa-spiro[2.5]octan-6-one

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL562231

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for OVALICIN

INCI name

OVALICIN

Description

1-Oxaspiro(2,5)octan-6-one, 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-4-hydroxy-5-methoxy-, (1S,2R,3S,4R,5S)-(-)-

Record provenance

Inventory reference: 85418
Imported identity: OVALICIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for OVALICIN

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Key data

CAS

19683-98-8

—

Restriction

—

Function

ANTI-SEBORRHEIC: Preventing or relieving the symptoms of seborrhea and/or seborrheic dermatitis, including dandruff.
ANTIMICROBIAL: Preventing and/or slowing down microbial growth.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#18494 · OVALICIN

Ingredients with overlapping formulation functions

MYRISTAMIDOPROPALKONIUM CHLORIDEANTI-SEBORRHEIC, ANTIMICROBIAL, ANTIPLAQUE

NAGEIA NAGI SEED OILANTI-SEBORRHEIC, ANTI-SEBUM, SKIN PROTECTING

NIOBIUM PENTOXIDEANTI-SEBORRHEIC; ANTIMICROBIAL; ANTI-SEBUM; DEODORANT; ORAL CARE; OXIDISING

OPUNTIA HUMIFUSA LEAF EXTRACTANTI-SEBORRHEIC, ANTI-SEBUM, ANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING - EMO…

OXIDIZED BETA-GLUCANABRASIVE, ANTI-SEBORRHEIC, ANTIMICROBIAL, DEODORANT, SKIN CONDITIONING

PEG-6 UNDECYLENATEANTI-SEBORRHEIC, SURFACTANT - CLEANSING

PETROSELINIC ACIDANTI-SEBORRHEIC; ANTIMICROBIAL; SKIN CONDITIONING - EMOLLIENT; SKIN PROTECTING; SKIN CONDITIONING -…

PEUMUS BOLDUS LEAF OILANTI-SEBORRHEIC, PERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How OVALICIN appears in the CosIng inventory

The CosIng inventory lists OVALICIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

OVALICIN is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

OVALICIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, OVALICIN carries the following function designation(s):

CAS 19683-98-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for OVALICIN

This page reproduces the CosIng inventory entry for OVALICIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research OVALICIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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