What does the restriction note for RETINOIC ACID mean?

The restriction field for RETINOIC ACID reads: II/375. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 302-79-4?

CAS 302-79-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains RETINOIC ACID?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8506715/10/2010

RETINOIC ACID

3,7-Dimethyl-9-(2.6.6-Trimethyl-1-Cyclohexen-1-yl)-2,4,6,8-Nonatetraenoic Acid

RETINOIC ACID is linked to 1 EU annex record on this page. Inventory note: II/375.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Prohibited Open this evidence	1	English
Canada	Evidence linked Prohibited Open this evidence	1	English and French
New Zealand	Evidence linked Prohibited Open this evidence	1	English
ASEAN	Evidence linked Prohibited Open this evidence	1	English and national languages
China	Evidence linked Prohibited Open this evidence	1	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Evidence linked Prohibited Open this evidence	1	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Evidence linked Prohibited Open this evidence	1	Portuguese with INCI crosswalks
India	Evidence linked Prohibited Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Prohibited Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 302-79-4

CAS 302-79-4PubChem CID 444795

Retinoic Acid

All-trans-retinoic acid is a retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. It has a role as an antioxidant, an antineoplastic agent, a keratolytic drug, a signalling molecule, a retinoid X receptor agonist, an anti-inflammatory agent, a retinoic acid receptor agonist, an AP-1 antagonist and a human metabolite. It is a vitamin A and a retinoic acid. It is a conjugate acid of an all-trans-retinoate. — ChEBI

IUPAC name: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid

Molecular formula: C20H28O2
Molecular weight: 300.4 g/mol
Exact mass: 300.208930132 Da
XLogP3: 6.3
Topological polar surface area: 37.3 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

tretinoinall-trans-Retinoic acidVitamin A acidtrans-Retinoic acidATRAAberelEudynaDermairol

16 more reported names

Renovaall-trans-Vitamin A acidCordes vasRetin ATretin Mall-trans-TretinoinRetionic acidall-trans-Vitamin A1 acidbeta-RaRetin-A MicroVitamin A1 acid, all-trans-beta-Retinoic acidTretinoinaAtralinall-(E)-Retinoic acidAll Trans Retinoic Acid

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:15367
ChEMBL:CHEMBL38
EPA DTXSID:DTXSID7021239
PubMed:41627613
PubMed:40504024
PubMed:40359302
PubMed:40064378
PubMed:40024514
PubMed:39571964
PubMed:38971454
PubMed:38179723
PubMed:38091671
PubMed:38070836
PubMed:38040126
PubMed:37989595

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for RETINOIC ACID

INCI name

RETINOIC ACID

Description

3,7-Dimethyl-9-(2.6.6-Trimethyl-1-Cyclohexen-1-yl)-2,4,6,8-Nonatetraenoic Acid

Record provenance

Inventory reference: 85067
Imported identity: RETINOIC ACID
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for RETINOIC ACID

Annex II Restriction reference

Entry 375

Tretinoin (INN) (retinoic acid and its salts)

CAS: 302-79-4

EC: 206-129-0

Key data

CAS

302-79-4

206-129-0

Restriction

II/375

Function

NOT REPORTED: No function currently reported.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#24133 · RETINOIC ACID

Ingredients with overlapping formulation functions

R-ESCHERICHIA COLI THIOREDOXIN-1NOT REPORTED

R-MUSSEL POLYPEPTIDE-2NOT REPORTED

R-SYNECHOCOCCUS POLYPEPTIDE-1NOT REPORTED

RESVERATROL TRIBUTYL ETHERNOT REPORTED

RH-POLYPEPTIDE-111NOT REPORTED

RH-POLYPEPTIDE-114NOT REPORTED

RH-POLYPEPTIDE-115NOT REPORTED

RH-POLYPEPTIDE-21NOT REPORTED

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How RETINOIC ACID appears in the CosIng inventory

The CosIng inventory lists RETINOIC ACID as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

RETINOIC ACID is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

RETINOIC ACID appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for RETINOIC ACID reads: "II/375". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, RETINOIC ACID carries the following function designation(s):

NOT REPORTED

CAS 302-79-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for RETINOIC ACID

This page combines the CosIng inventory entry for RETINOIC ACID with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research RETINOIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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