InventoryRef 8354215/10/2010
1,6-HEXANEDIAMINE
Hexamethylenediamine
1,6-HEXANEDIAMINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
CAS 124-09-4PubChem CID 16402
Hexamethylenediamine
Hexane-1,6-diamine is a C6 alkane-alpha,-diamine. It has a role as a human xenobiotic metabolite. It derives from a hydride of a hexane. — ChEBI
- IUPAC name
- hexane-1,6-diamine
- Molecular formula
- C6H16N2
- Molecular weight
- 116.20 g/mol
- Exact mass
- 116.131348519 Da
- XLogP3
- -0.2
- Topological polar surface area
- 52.0 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
1,6-HexanediamineHMDAHEXAMETHYLENE DIAMINE1,6-Hexylenediamine1,6-Diamino-n-hexanediaminohexaneHexane, 1,6-diamino-NCI-C61405
16 more reported names
HEX-NH2NSC 9257CCRIS 6224H2N(CH2)6NH2HSDB 189UNII-ZRA5J5B2QWEINECS 204-679-6BRN 1098307AI3-37283NSC-9257HEXANEMETHYLENEDIAMINE-CHEBI:39618EC 204-679-64-04-00-01320 (Beilstein Handbook Reference)RefChem:7518HMD(A)
External database identifiers
- ChEBI:CHEBI:39618
- ChEMBL:CHEMBL303004
- EPA DTXSID:DTXSID5024922
- PubMed:22940750
- PubMed:22922114
- PubMed:22908412
- PubMed:22711515
- PubMed:22493610
- PubMed:22448137
- PubMed:22334778
- PubMed:22272120
- PubMed:22132086
- PubMed:22102881
- PubMed:22058736
- PubMed:22020167
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match16402
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 734 to 788 °F (NTP, 1992) Source: CAMEO Chemicals
- Autoignition Temperature: 305 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 401 °F at 760 mmHg (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 205 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 199-205 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 401 °F Source: Occupational Safety and Health Administration (OSHA)
- Color/Form: COLORLESS LEAFLETS Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: RHOMBIC BIPYRAMIDAL PLATES Source: Hazardous Substances Data Bank (HSDB)
- Density: (anhyd.) 0.799 at 140.0 °F (70% soln.) 0.933 at 20 °C (USCG, 1999) Source: CAMEO Chemicals
- Density: (anhyd) 0.799 at 60 °C (liquid) Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 0.93 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 0.799 at 140 °F (70% sol), 0.933 at 20 °C Source: Occupational Safety and Health Administration (OSHA)
- Dissociation Constants: pKb= 3.3, pKa= 10.7 Source: Hazardous Substances Data Bank (HSDB)
- Dissociation Constants: pKa = 11.02 (conjugate acid) Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 178 °F (NTP, 1992) Source: CAMEO Chemicals
- Flash Point: 85 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 160 °F OC Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 85 °C c.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Flash Point: 178 °F Source: Occupational Safety and Health Administration (OSHA)
- Melting Point: 108 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: 42 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 23-41 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: 108 °F Source: Occupational Safety and Health Administration (OSHA)
- Odor: ODOR OF PIPERIDINE Source: Hazardous Substances Data Bank (HSDB)
- Odor: Weak, fishy Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Hexamethylenediamine, solid is a colorless crystalline solid. It is soluble in water. It is corrosive to metals and tissue. Produces toxic oxides of nitrogen during combustion. Source: CAMEO Chemicals
- Physical Description: Hexamethylenediamine, solution appears as a clear colorless liquid. Burns although some effort is required to ignite. Soluble in water. Corrosive to metals and tissue. Produces toxic oxides of nitrogen during combustion. Used to make nylon. Source: CAMEO Chemicals
- Physical Description: CBI; Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless solid; [Hawley] Hygroscopic; [ICSC] Has an ammonia-like or fishy odor; [CHEMINFO] White solid; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: HYGROSCOPIC PELLETS OR FLAKES WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Physical Description: Colorless crystalline solid or clear liquid. Source: Occupational Safety and Health Administration (OSHA)
- Solubility: greater than or equal to 100 mg/mL at 73 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: FREELY SOL IN WATER; SLIGHTLY SOL IN ALC, BENZENE Source: Hazardous Substances Data Bank (HSDB)
- Solubility: SOMEWHAT SOL IN ETHER Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Water solubility = 2,460,000 mg/l at 4.5 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Solubility in water: soluble Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 1.1 mmHg at 122 °F ; 3 mmHg at 140 °F (NTP, 1992) Source: CAMEO Chemicals
- Vapor Pressure: 0.4 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: Vapor pressure, Pa at 50 °C: 200 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 1.1 mmHg at 122 °F, 3 mmHg at 140 °F Source: Occupational Safety and Health Administration (OSHA)
- Exposure Routes: The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whene Source: CAMEO Chemicals
- First Aid: Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:; Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. Removal of solidified molten material from skin requires medical assistance. (ERG, 2024) Source: CAMEO Chemicals
- ERG2024, Guide 153 (Hexamethylenediamine, solution; Hexamethylenediamine, solid): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- ERG2024, Guide 153 (Hexamethylenediamine, solid; Hexamethylenediamine, solution): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302+H312 (38.6%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (> 99.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318 (53.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1248 reports by companies from 31 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard] Source: NITE-CMC
- Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P321, P330, P333+P317, P362+P364, P363, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
- Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P321, P330, P333+P317, P362+P364, P363, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Environmental Bioconcentration: An estimated BCF value of 1 was calculated for hexamethylene diamine(SRC), using an estimated log Kow of 0.35(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 286(SRC), determined from a structure estimation method(2), indicates that hexamethylene diamine is expected to have moderate mobility in soil(SRC). Volatilization of hexamethylene diamine is not expected from moist soil surfaces(SRC) given an estimated Henry's Law constant of 3.2X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Volatilization of hexamethylene diamine from dry soil surfaces is not expected(SRC) based on an extrapolated vapor pressure of 0.12 mm Hg(SRC) at 25 °C(4). Biodegradation is expected to be an important environmental fate process for this compound(SRC). Standard BOD dilution techniques with activated sludge indicate that hexamethylene diamine biodegrades under aerobic conditions(5-7). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 286(SRC), determined from a structure estimation method(2), indicates that hexamethylene diamine is expected to adsorb to suspended solids and sediment in water(SRC). Hexamethylene diamine is not expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 3.2X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). An experimental pKa value of 11(5), indicates that hexamethylene diamine will not dissociate significantly at environmentally important pH values(SRC). Biodegradation is expected to occur slowly in aqueous environments(SRC). Degradation rates of 4% and 10% were observed for hexamethylene diamine (50 ppm) incubated in water from the Mino River, Japan and seawater off the coast of Japan over a 3 day incubation period(6). According to a classification scheme(7), an estimated BCF value of 1(3,SRC), from an estimated log Kow of 0.35(8,SRC), suggests that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hexamethylene diamine, which has an extrapolated vapor pressure of 0.12 mm Hg at 25 °C(2,SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase hexamethylene diamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 6 hours(3,SRC). Source: Hazardous Substances Data Bank (HSDB)
- Industry Uses: Intermediate; Not Known or Reasonably Ascertainable; Monomers; Other Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used as an intermediate to make polyamides with applications in fiber, plastics, polyurethane coatings and adhesives, specialty nylons (monofilaments and inks), and specialty chemicals (biocides, petroleum additives, and phenol purification); [eChemPortal: SIDSUNEP] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: CHEM INT FOR NYLON-TYPE POLYAMIDE RESINS Source: Hazardous Substances Data Bank (HSDB)
- Uses: Used to prepare hexamethylene diisocyanate. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for 1,6-HEXANEDIAMINE
INCI name
1,6-HEXANEDIAMINE
Description
Hexamethylenediamine
Record provenance
- Inventory reference
- 83542
- Imported identity
- 1,6-HEXANEDIAMINE
- Source update
- 15/10/2010
Annex records for 1,6-HEXANEDIAMINE
Key data
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How 1,6-HEXANEDIAMINE appears in the CosIng inventory
The CosIng inventory lists 1,6-HEXANEDIAMINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
1,6-HEXANEDIAMINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
1,6-HEXANEDIAMINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.
According to the EU CosIng inventory, 1,6-HEXANEDIAMINE carries the following function designation(s):
CAS 124-09-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for 1,6-HEXANEDIAMINE
This page reproduces the CosIng inventory entry for 1,6-HEXANEDIAMINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research 1,6-HEXANEDIAMINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
Tools & next steps
Check your formula
Scan a full INCI list to detect 1,6-HEXANEDIAMINE and any linked EU annex restrictions or allergen flags.
INCI CheckerSearch similar ingredients
Find other inventory ingredients and annex entries related to 1,6-HEXANEDIAMINE, its identifiers or nearby name variants.
Search