Is THEOBROMINE safe to use in EU cosmetics?

THEOBROMINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 83-67-0?

CAS 83-67-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains THEOBROMINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8076015/10/2010

THEOBROMINE

1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-

THEOBROMINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 83-67-0

CAS 83-67-0PubChem CID 5429

Theobromine

Theobromine is an odorless white crystalline powder. Bitter taste. pH (saturated solution in water): 5.5-7. (NTP, 1992) — CAMEO Chemicals

IUPAC name: 3,7-dimethylpurine-2,6-dione

Molecular formula: C7H8N4O2
Molecular weight: 180.16 g/mol
Exact mass: 180.06472551 Da
XLogP3: -0.8
Topological polar surface area: 67.2 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

3,7-DimethylxanthineDiurobromineTheosalvoseSantheoseTeobrominTheostene3,7-Dimethyl-3,7-dihydro-1H-purine-2,6-dioneThesal

16 more reported names

XantheoseFEMA No. 35913,7-Dihydro-3,7-dimethyl-1H-purine-2,6-dioneTheobrominum1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-SC 15090OBD445WZ5P3,7-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dioneNSC-5039SC-15090CHEBI:28946RefChem:6504201-494-2ThesodateTheobrominXanthine, 3,7-dimethyl-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:28946
ChEMBL:CHEMBL1114
EPA DTXSID:DTXSID9026132
PubMed:31132250
PubMed:29968805
PubMed:23094271
PubMed:22895979
PubMed:22824731
PubMed:22751681
PubMed:22690251
PubMed:22675703
PubMed:22662200
PubMed:22591221
PubMed:22554278
PubMed:22540095

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for THEOBROMINE

INCI name

THEOBROMINE

Description

1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-

Record provenance

Inventory reference: 80760
Imported identity: THEOBROMINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for THEOBROMINE

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Key data

CAS

83-67-0

201-494-2

Restriction

—

Function

FRAGRANCE: Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28736 · THEOBROMINE

Ingredients with overlapping formulation functions

THALICTRUM OCCIDENTALE FLOWER EXTRACTFRAGRANCE

THEOBROMA CACAO LEAF CELL EXTRACTFRAGRANCE, SKIN PROTECTING

THEOBROMA CACAO SEED BUTTERFRAGRANCE, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

THEOBROMA GRANDIFLORUM FRUIT JUICEANTIOXIDANT, FRAGRANCE, HUMECTANT, PERFUMING

THIAMINE HCLFRAGRANCE, SKIN CONDITIONING

THIOLACTIC ACIDANTIOXIDANT, DEPILATORY, FRAGRANCE, HAIR WAVING OR STRAIGHTENING, REDUCING

THUJA OCCIDENTALIS LEAF OILFRAGRANCE, PERFUMING, TONIC

THUJA ORIENTALIS WATERFLAVOURING, FRAGRANCE, PERFUMING, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How THEOBROMINE appears in the CosIng inventory

The CosIng inventory lists THEOBROMINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

THEOBROMINE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

THEOBROMINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, THEOBROMINE carries the following function designation(s):

CAS 83-67-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for THEOBROMINE

This page reproduces the CosIng inventory entry for THEOBROMINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research THEOBROMINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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