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CAS 7651-99-2 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 7941415/10/2010

PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE

Pentasodium trihydrogen, ethylenedinitrilotetrakis(methylphosphonate)

PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 7651-99-2

CAS 7651-99-2PubChem CID 165629

Lexidronam pentasodium

Lexidronam Pentasodium is the pentasodium salt form of lexidronam (ethylenediaminetetramethylenephosphonic acid; EDTMP), a phosphonate analog of ethylenediaminetetraacetic acid (EDTA), with chelating activity. Lexidronam binds to and associates with hydroxyapatite crystals concentrated in areas of bone turnover. It has been used as a radiopharmaceutical in complexes with radioactive metals to selectively deliver cytotoxic radiation to osteoblastic bone metastases. — NCI Thesaurus (NCIt)

IUPAC name: pentasodium;[2-[bis[[hydroxy(oxido)phosphoryl]methyl]amino]ethyl-(phosphonatomethyl)amino]methyl-hydroxyphosphinate

Molecular formula: C6H15N2Na5O12P4
Molecular weight: 546.03 g/mol
Exact mass: 545.9063933 Da
Topological polar surface area: 251.0 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 14
Covalent units: 6
Defined stereocentres: 0

Also known as

EDTMP pentasodium saltLexidronam pentasodium saltEthylenediamine tetra(methylenephosphonic acid) pentasodium salt2ZYX2V82ADEINECS 231-615-4Phosphonic acid, [1,2-ethanediylbis[nitrilobis(methylene)]]tetrakis-, pentasodium saltEthylenediaminetetramethylenephosphonic acid, pentasodium saltPentasodium Ethylenediamine Tetramethylene Phosphonate

12 more reported names

Phosphonic acid, (1,2-ethanediylbis(nitrilobis(methylene)))tetrakis-, pentasodium saltPentasodium trihydrogen (ethane-1,2-diylbis(nitrilobis(methylene)))tetrakisphosphonatePhosphonic acid, P,P',P'',P'''-(1,2-ethanediylbis(nitrilobis(methylene)))tetrakis-, sodium salt (1:5)PENTASODIUM ETHYLENEDIAMINETETRA(METHYLENEPHOSPHONATE)pentasodium trihydrogen [ethane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonatePhosphonic acid, P,P',P'',P'''-[1,2-ethanediylbis[nitrilobis(methylene)]]tetrakis-, sodium salt (1:5)RefChem:799052PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE [INCI]pentasodium (ethylenediamine)tetramethylenephosphonateUNII-2ZYX2V82ADSODIUM EDTMPPentasodium ({(2-{bis[(hydroxyphosphinato)methyl]amino}ethyl)[(hydroxyphosphinato)methyl]amino}methyl)phosphonate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID4064763

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE

INCI name

PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE

Description

Pentasodium trihydrogen, ethylenedinitrilotetrakis(methylphosphonate)

Record provenance

Inventory reference: 79414
Imported identity: PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE

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Key data

CAS

7651-99-2

231-615-4

Restriction

—

Function

CHELATING: Forming complexes with metal ions which could affect the stability and/or appearance of cosmetics.
VISCOSITY CONTROLLING: Increasing or decreasing the viscosity (thickness) of cosmetics.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#20427 · PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE

Ingredients with overlapping formulation functions

PALMITOYL TETRAPEPTIDE-132 PENTAPEPTIDE-116ANTIOXIDANT; CHELATING

PENTAPEPTIDE-27ANTIOXIDANT, CHELATING, SKIN PROTECTING

PENTAPOTASSIUM TRIPHOSPHATEBUFFERING, CHELATING

PENTASODIUM AMINOTRIMETHYLENE PHOSPHONATECHELATING

PENTASODIUM PENTETATECHELATING

PENTASODIUM TRIPHOSPHATEBUFFERING, CHELATING

PENTETIC ACIDCHELATING

PHOSPHONOBUTANETRICARBOXYLIC ACIDANTICORROSIVE, BUFFERING, CHELATING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE appears in the CosIng inventory

The CosIng inventory lists PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE carries the following function designation(s):

CAS 7651-99-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE

This page reproduces the CosIng inventory entry for PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PENTASODIUM ETHYLENEDIAMINE TETRAMETHYLENE PHOSPHONATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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