Is SUBTILISIN safe to use in EU cosmetics?

SUBTILISIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 9014-01-1?

CAS 9014-01-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains SUBTILISIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 7931215/10/2010

SUBTILISIN

Enzymes, subtilisin

SUBTILISIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 9014-01-1

CAS 9014-01-1PubChem CID 3086051

Bacillomycin

bacillomycin has been reported in Bacillus subtilis and Saccharomyces cerevisiae with data available. — LOTUS - the natural products occurrence database

IUPAC name: 3-[(3R,6R,9S,16S,19R,22S,25S)-3,9-bis(2-amino-2-oxoethyl)-16-[(1R)-1-hydroxyethyl]-19-(hydroxymethyl)-6-[(4-hydroxyphenyl)methyl]-13-octyl-2,5,8,11,15,18,21,24-octaoxo-1,4,7,10,14,17,20,23-octazabicyclo[23.3.0]octacosan-22-yl]propanoic acid

Molecular formula: C45H68N10O15
Molecular weight: 989.1 g/mol
Exact mass: 988.48656150 Da
XLogP3: -1.1
Topological polar surface area: 408.0 Å²
Hydrogen-bond donors: 13
Hydrogen-bond acceptors: 15
Covalent units: 1
Defined stereocentres: 8

Also known as

SubtilisinsALK-enzymeAlcalaseBiopraseExtretexFungocinGenenaseNagarse

16 more reported names

Bacillomycin RSubtilisin BPNSubtilisin NOVOBacillopeptidase ABacillopeptidase BSubtilisin Carlsburg (Note: Commercial proteolytic enzymes are used in laundry detergents.)Subtilisin Carlsburg [Note: Commercial proteolytic enzymes are used in laundry detergents.]Subtilopeptidase ASubtilopeptidase BSubtilopeptidase CDafazyme PR BChirazyme P 1Proteolytic enzymesSubtilisin carlsburgThermoase PC-10Bioprotease B 10L

Open full PubChem record PubChem annotations 3D structure image

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for SUBTILISIN

INCI name

SUBTILISIN

Description

Enzymes, subtilisin

Record provenance

Inventory reference: 79312
Imported identity: SUBTILISIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for SUBTILISIN

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Key data

CAS

9014-01-1

232-752-2

Restriction

—

Function

KERATOLYTIC: Helping to eliminate the dead cells of the stratum corneum.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28011 · SUBTILISIN

Ingredients with overlapping formulation functions

RUBUS IDAEUS FRUIT EXTRACTASTRINGENT, KERATOLYTIC, SKIN CONDITIONING, SMOOTHING, TONIC

SALICYLAMIDEKERATOLYTIC

SALICYLIC ACIDANTI-SEBORRHEIC, FRAGRANCE, HAIR CONDITIONING, KERATOLYTIC, PRESERVATIVE, SKIN CONDITIONING

SODIUM LACTATEBUFFERING, HUMECTANT, KERATOLYTIC

SUTILAINSKERATOLYTIC

TAMARINDUS INDICA EXTRACTKERATOLYTIC, SMOOTHING

THIOGLYCERINDEPILATORY, HAIR WAVING OR STRAIGHTENING, KERATOLYTIC, REDUCING

THIOSALICYLIC ACIDANTIOXIDANT, KERATOLYTIC, REDUCING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SUBTILISIN appears in the CosIng inventory

The CosIng inventory lists SUBTILISIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SUBTILISIN is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SUBTILISIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SUBTILISIN carries the following function designation(s):

CAS 9014-01-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for SUBTILISIN

This page reproduces the CosIng inventory entry for SUBTILISIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SUBTILISIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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