Is GUAIAZULENE safe to use in EU cosmetics?

GUAIAZULENE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 489-84-9?

CAS 489-84-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains GUAIAZULENE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 7649615/10/2010

GUAIAZULENE

7-Isopropyl-1,4-dimethylazulene

GUAIAZULENE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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Market	Evidence status	Records	Source language
European Union	Source mapped Inventory entry; no linked annex rule	0	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Evidence linked Permitted list with conditions Open this evidence	1	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 489-84-9

CAS 489-84-9PubChem CID 3515

Guaiazulene

Guaiazulene is a sesquiterpene. It derives from a hydride of a guaiane. — ChEBI

IUPAC name: 1,4-dimethyl-7-propan-2-ylazulene

Molecular formula: C15H18
Molecular weight: 198.30 g/mol
Exact mass: 198.140850574 Da
XLogP3: 4.8
Topological polar surface area: 0.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 0
Covalent units: 1
Defined stereocentres: 0

Also known as

1,4-Dimethyl-7-isopropylazulene7-Isopropyl-1,4-dimethylazuleneVetivazulenAzulonS-GuaiazuleneKessazulenPurazulenSilazulon

16 more reported names

UroazulenAzunolguaiazulenGuajazuleneVaumigan1,4-Dimethyl-7-(1-methylethyl)azuleneAzulene, 1,4-dimethyl-7-(1-methylethyl)-3,8-Dimethyl-5-(2-propyl)azulene1,4-dimethyl-7-(propan-2-yl)azuleneNSC-47142OZ1K9JKQCCHEBI:5550RefChem:144607207-701-2EucazulenGuiazulene

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:5550
ChEMBL:CHEMBL1408759
EPA DTXSID:DTXSID7045996
PubMed:22474965
PubMed:22148226
PubMed:21915223
PubMed:21554980
PubMed:21323756
PubMed:20854889
PubMed:20385420
PubMed:19904921
PubMed:19216881
PubMed:18991747
PubMed:18706312
PubMed:18680092

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for GUAIAZULENE

INCI name

GUAIAZULENE

Description

7-Isopropyl-1,4-dimethylazulene

Record provenance

Inventory reference: 76496
Imported identity: GUAIAZULENE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for GUAIAZULENE

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Key data

CAS

489-84-9

207-701-2

Restriction

—

Function

ANTIMICROBIAL: Preventing and/or slowing down microbial growth.
PERFUMING: Used for perfume and aromatic raw materials.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#11489 · GUAIAZULENE

Ingredients with overlapping formulation functions

GLYCINE MAX CALLUS EXTRACTANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING, SKIN PROTECTING

GLYCINE MAX PHYTOPLACENTA EXTRACTANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN PROTECTING

GLYOXALANTIMICROBIAL, PERFUMING

GOSSYPETIN PENTAACETATEANTIMICROBIAL; ANTIOXIDANT

GYNOSTEMMA PENTAPHYLLUM CALLUS EXTRACTANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING

HABERLEA RHODOPENSIS CALLUS EXTRACTANTIMICROBIAL, ANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

HEDERA HELIX EXTRACTANTICAKING, ANTIMICROBIAL, ASTRINGENT, SKIN CONDITIONING, SOOTHING, TONIC

HEDERA HELIX LEAF/STEMANTICAKING, ANTIMICROBIAL, ASTRINGENT, SKIN CONDITIONING, SOOTHING, TONIC

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How GUAIAZULENE appears in the CosIng inventory

The CosIng inventory lists GUAIAZULENE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

GUAIAZULENE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

GUAIAZULENE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, GUAIAZULENE carries the following function designation(s):

CAS 489-84-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for GUAIAZULENE

This page reproduces the CosIng inventory entry for GUAIAZULENE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research GUAIAZULENE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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