InventoryRef 7562815/10/2010
DIACETONE ALCOHOL
4-Hydroxy-4-methylpentan-2-one
DIACETONE ALCOHOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
CAS 123-42-2PubChem CID 31256
Diacetone Alcohol
Diacetone alcohol appears as a clear colorless liquid with a pleasant odor. Flash point below 141 °F. Less dense than water. Vapors heavier than air. — CAMEO Chemicals
- IUPAC name
- 4-hydroxy-4-methylpentan-2-one
- Molecular formula
- C6H12O2
- Molecular weight
- 116.16 g/mol
- Exact mass
- 116.083729621 Da
- XLogP3
- -0.2
- Topological polar surface area
- 37.3 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
4-HYDROXY-4-METHYL-2-PENTANONEDiacetonalkoholDiketone alcoholDiacetonalcoholTyrantonAcetonyldimethylcarbinolPyranton ADiacetone
16 more reported names
PyrantonDiacetone-alcool2-Pentanone, 4-hydroxy-4-methyl-Diacetonalcool2-Methyl-2-pentanol-4-oneDiacetonyl alcohol4-Hydroxy-2-keto-4-methylpentane4-Idrossi-4-metil-pentan-2-oneDimethyl acetonyl carbinol4-Hydroxy-4-methylpentanone-24-Hydroxy-4-methyl-pentan-2-on4-Hydroxy-4-methyl pentan-2-oneQ7WP157PTDNSC-9005CHEBI:55381RefChem:5741
External database identifiers
- ChEBI:CHEBI:55381
- ChEMBL:CHEMBL3182048
- EPA DTXSID:DTXSID6024917
- PubMed:22426231
- PubMed:22416247
- PubMed:21702740
- PubMed:21075070
- PubMed:20379812
- PubMed:20188896
- PubMed:19570608
- PubMed:18585296
- PubMed:18372139
- PubMed:18155147
- PubMed:18031025
- PubMed:17722281
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match31256
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 1118 °F (USCG, 1999) Source: CAMEO Chemicals
- Autoignition Temperature: ACETONE-FREE 603 °C (1118 °F); COMMERCIAL 643 °C (1190 °F) Source: Hazardous Substances Data Bank (HSDB)
- Autoignition Temperature: 640 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 328 °F at 760 mmHg (USCG, 1999) Source: CAMEO Chemicals
- Boiling Point: 167.9 °C AT 760 MM HG; 108.2 °C AT 100 MM HG; 72.0 °C AT 20 MM HG; 58.8 °C AT 10 MM HG; 22.0 °C AT 1.0 MM HG Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 164.00 to 166.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 169-171 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 334 °F Source: Occupational Safety and Health Administration (OSHA)
- Boiling Point: 167.9 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Boiling Point: 334 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Color/Form: COLORLESS LIQUID Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Colorless liquid. Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Faint, minty odor. Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.938 at 68 °F (USCG, 1999) - Less dense than water; will float Source: CAMEO Chemicals
- Density: 0.9306 @ 25 °C/4 °C (0.940 FOR TECHNICAL GRADE) Source: Hazardous Substances Data Bank (HSDB)
- Density: PERCENT IN SATURATED AIR: 0.13 (20 °C); DENSITY OF SATURATED AIR: 1.005 (AIR= 1) Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 0.93 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 0.94 Source: Occupational Safety and Health Administration (OSHA)
- Density: 0.9306 @ 20°C Source: PAC Chemical Database, U.S. Department of Energy
- Density: 0.94 Source: The National Institute for Occupational Safety and Health (NIOSH)
- Flash Point: 125 °F (USCG, 1999) Source: CAMEO Chemicals
- Flash Point: 66 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 66 °C (OPEN CUP); COMMERCIAL GRADE IS 8 °C (CLOSED CUP) & 13 °C (OPEN CUP) Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 58 °C c.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Flash Point: 125 °F Source: Occupational Safety and Health Administration (OSHA)
- Flash Point: 125 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- LogP: -0.14 - 1.03 (calculated) Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -45 °F (USCG, 1999) Source: CAMEO Chemicals
- Melting Point: -44 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -44 °C Source: Human Metabolome Database (HMDB)
- Melting Point: -47 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -47 °F Source: Occupational Safety and Health Administration (OSHA)
- Melting Point: -44 °C Source: PAC Chemical Database, U.S. Department of Energy
- Melting Point: -47 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Odor: FAINT PLEASANT ODOR Source: Hazardous Substances Data Bank (HSDB)
- Odor: Minty odor Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Diacetone alcohol appears as a clear colorless liquid with a pleasant odor. Flash point below 141 °F. Less dense than water. Vapors heavier than air. Source: CAMEO Chemicals
- Physical Description: CBI; Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless liquid with a faint, minty odor; [NIOSH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Physical Description: Colorless liquid with a faint, minty odor. Source: Occupational Safety and Health Administration (OSHA)
- Physical Description: Colorless liquid with a faint, minty odor. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Refractive Index: INDEX OF REFRACTION: 1.4232 AT 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Miscible (NIOSH, 2024) Source: CAMEO Chemicals
- Solubility: MISCIBLE WITH WATER, ALCOHOL, ETHER, OTHER SOLVENTS Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Water solubility of 1.0X10+6 mg/l Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 1000 mg/mL at 25 °C Source: Human Metabolome Database (HMDB)
- Solubility: Solubility in water: miscible Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: Miscible Source: The National Institute for Occupational Safety and Health (NIOSH)
- Vapor Pressure: 3.62 mmHg (USCG, 1999) Source: CAMEO Chemicals
- Vapor Pressure: 1.71 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 0.97 MM HG AT 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: Vapor pressure, kPa at 20 °C: 0.108 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 1 mmHg Source: Occupational Safety and Health Administration (OSHA)
- Vapor Pressure: 1.1 [mm Hg] @20 °C Source: PAC Chemical Database, U.S. Department of Energy
- Vapor Pressure: 1 mmHg Source: The National Institute for Occupational Safety and Health (NIOSH)
- Exposure Routes: The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Exposure Routes: inhalation, ingestion, skin and/or eye contact Source: The National Institute for Occupational Safety and Health (NIOSH)
- First Aid: Excerpt from NIOSH Pocket Guide for Diacetone alcohol:; Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: WATER FLUSH PROMPTLY - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.; Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.; Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024) Source: CAMEO Chemicals
- ERG2024, Guide 129 (Diacetone alcohol): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Note: This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1556) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H226 (32.3%): Flammable liquid and vapor [Warning Flammable liquids]; H319 (99.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (31.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H361d (16.5%): Suspected of damaging the unborn child [Warning Reproductive toxicity] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P318, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1556 reports by companies from 53 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 1556 reports by companies.; There are 52 notifications provided by 1555 of 1556 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] Source: NITE-CMC
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P318, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Signal: Warning Source: NITE-CMC
- NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
- Target Organs: Eyes, skin, respiratory system, central nervous system, liver Source: The National Institute for Occupational Safety and Health (NIOSH)
- Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
- Environmental Bioconcentration: An estimated BCF of 0.50 can be calculated(SRC) from an estimated log Kow of -0.098(2) using a recommended regression equation(1). Based upon the estimated BCF and the reported infinite solubility of the compound in water(3), 4-hydroxy-4-methyl-2-pentanone will not be expected to significantly bioconcentrate in aquatic organisms(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: If 4-hydroxy-4-methyl-2-pentanone is released to soil, it will be expected to exhibit very high mobility(1), based upon the reported infinite solubility of the compound in water(2) and an estimated Koc of 21 calculated(3,SRC) from a measured log Kow(4). The compound may, therefore, leach through soil to groundwater if it does not biodegrade first(SRC). It may be subject to biodegradation in soil based upon results observed in laboratory biodegradation aqueous aerobic screening tests using acclimated mixed microbial cultures as inoculums(5,6) provided suitably acclimated microbial populations are present(7,SRC). It should not be subject to volatilization from moist near surface soil based upon(3,SRC) an estimated Henry's Law constant of 4.24X10-9 atm-cu m/mole(9,SRC). However, it may volatilize from dry near-surface soil and other dry surfaces based upon its vapor pressure of 1.71 mm Hg at 25 °C(8). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: If 4-hydroxy-4-methyl-2-pentanone is released to water, it will not be expected to adsorb to sediment or suspended particulate matter or to bioconcentrate in aquatic organisms based upon its estimated Koc and BCF, respectively, calculated(1,SRC) from the measured log Kow(2), and its high solubility in water(3). Although no data were found regarding biodegradation in environmental media, the compound may be subject to biodegradation in natural waters based upon results observed in laboratory aqueous aerobic biodegradation screening tests using acclimated mixed microbial cultures as inoculums(4,5) provided suitably acclimated microbial populations are present(6,SRC). It should not be subject to volatilization from surface waters based upon(1,SRC) an estimated Henry's Law constant of 4.24X10-9 atm-cu m/mole(7,SRC) Hydrolysis should not be an important removal process since aliphatic alcohols and ketones (the two functional groups that 4-hydroxy-4-methyl-2-pentanone contains) generally are resistant to hydrolysis(1). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: If 4-hydroxy-4-methyl-2-pentanone is released to the atmosphere, it can be expected to exist mainly in the vapor-phase in the ambient atmosphere(1,SRC) based upon an experimental vapor pressure of 1.71 mm Hg at 25 °C(2). The estimated rate constant for vapor-phase reaction with photochemically produced hydroxyl radicals is 1.34X10-12 cu cm/molecule-sec at 25 °C(3) which corresponds to an atmospheric half-life of 12 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(SRC). 4-Hydroxy-4-methyl-2-pentanone may be susceptible to direct photolysis in the atmosphere(SRC) based upon its possible absorption(SRC) of light at wavelengths >290 nm(4). Based upon its high water solubility(5), the compound may be susceptible to removal from the atmosphere by washout(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Not Known or Reasonably Ascertainable; Flux agent; Pigment; Solvent Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Cleaning agent; Not Known or Reasonably Ascertainable; Intermediate; Pigment; Solvent Source: EPA Chemical Data Reporting (CDR)
- Cosmetic Ingredient Review Link: CIR ingredient: Diacetone Alcohol Source: Cosmetic Ingredient Review (CIR)
- Sources/Uses: Used in antifreeze and brake fluids; also used as a solvent to make nitrocellulose, cellulose acetate, celluloid, pigments, waxes, and oils; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Painting (Solvents) [Category: Paint] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: INT IN SYNTH OF MESITYL OXIDE, HEXALENE GLYCOL AND OTHER ORG CHEMS Source: Hazardous Substances Data Bank (HSDB)
- Uses: SOLVENT FOR CELLULOSE ACETATE, NITROCELLULOSE, CELLULOID, FATS, OILS, WAXES, RESINS; IN SOME ANTIFREEZE SOLUTIONS & HYDRAULIC FLUIDS; PRESERVATIVE IN PHARMACEUTICAL PREPN Source: Hazardous Substances Data Bank (HSDB)
- Uses: COATING COMPOSITIONS & MERCERIZATIONS; SOLVENT FOR CERTAIN PIGMENTS; MANUFACTURE OF QUICK DRYING INKS, PHOTOGRAPHIC FILM, METAL CLEANING CMPD Source: Hazardous Substances Data Bank (HSDB)
- Uses: MAKING ARTIFICIAL SILK & LEATHER Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for DIACETONE ALCOHOL
INCI name
DIACETONE ALCOHOL
Description
4-Hydroxy-4-methylpentan-2-one
Record provenance
- Inventory reference
- 75628
- Imported identity
- DIACETONE ALCOHOL
- Source update
- 15/10/2010
Annex records for DIACETONE ALCOHOL
Key data
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How DIACETONE ALCOHOL appears in the CosIng inventory
The CosIng inventory lists DIACETONE ALCOHOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
DIACETONE ALCOHOL is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
DIACETONE ALCOHOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.
CAS 123-42-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for DIACETONE ALCOHOL
This page reproduces the CosIng inventory entry for DIACETONE ALCOHOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research DIACETONE ALCOHOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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