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CAS 3539-43-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 7496715/10/2010

CETYL PHOSPHATE

Hexadecyl dihydrogen phosphate

CETYL PHOSPHATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 3539-43-3

CAS 3539-43-3PubChem CID 19059

Hexadecyl phosphate

The CIR Expert Panel concluded the following 28 alkyl phosphates are safe in the present practices of use and concentration in cosmetics when formulated to be non-irritating...Cetyl Phosphate... — Cosmetic Ingredient Review (CIR)

IUPAC name: hexadecyl dihydrogen phosphate

Molecular formula: C16H35O4P
Molecular weight: 322.42 g/mol
Exact mass: 322.22729659 Da
XLogP3: 6.2
Topological polar surface area: 66.8 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

CETYL PHOSPHATE1-Hexadecanol, dihydrogen phosphateHostaphat CC 100VT07D6X67OMACKESTER CEPCRODAFOS MCARefChem:786052222-581-1

9 more reported names

AMPHISOL Amonocetyl phosphatecetyl dihydrogen phosphateUNII-VT07D6X67OPhosphoric acid monohexadecyl esterEINECS 222-581-1monocetylphosphoric acid1-Hexadecanol, 1-(dihydrogen phosphate)DB-048793

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL479322
EPA DTXSID:DTXSID1045039
PubMed:22882126
PubMed:18577434
PubMed:17570381
PubMed:17125781
PubMed:16430267
PubMed:16380126
PubMed:16054158
PubMed:11996827
PubMed:10395496

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CETYL PHOSPHATE

INCI name

CETYL PHOSPHATE

Description

Hexadecyl dihydrogen phosphate

Record provenance

Inventory reference: 74967
Imported identity: CETYL PHOSPHATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for CETYL PHOSPHATE

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Key data

CAS

3539-43-3

222-581-1

Restriction

—

Function

SURFACTANT - CLEANSING: Wetting body surfaces, emulsifying or solubilizing oils, and suspending soil (generally, such ingredients contribute to the foaming and lathering properties of cleansing products).
SURFACTANT - EMULSIFYING: Helping suspensions or dispersions of liquids in a second liquid by reducing the surface tension of the substances to be emulsified.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#6014 · CETYL PHOSPHATE

Ingredients with overlapping formulation functions

CETYL PEG-8 DIMETHICONESURFACTANT - EMULSIFYING

CETYL PEG/PPG-10/1 DIMETHICONESKIN CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

CETYL PEG/PPG-15/15 BUTYL ETHER DIMETHICONESKIN CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

CETYL PEG/PPG-7/3 DIMETHICONEEMULSION STABILISING, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

CETYLPYRIDINIUM CHLORIDEANTIMICROBIAL, ANTISTATIC, DEODORANT, HAIR CONDITIONING, ORAL CARE, SURFACTANT - CLEANSING, SURFACT…

CHIMYL STEARATESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SURFACTANT - EMULSIFYING

CHITOSAN BEESWAX AMIDE HYDROXYPROPYLTRIMONIUM CHLORIDESKIN CONDITIONING - EMOLLIENT; SURFACTANT - EMULSIFYING; FILM FORMING; HAIR CONDITIONING; SKIN PROT…

CHITOSAN ISOSTEARAMIDE HYDROXYPROPYLTRIMONIUM CHLORIDEHAIR CONDITIONING, SKIN CONDITIONING, SKIN PROTECTING, SURFACTANT - CLEANSING, SURFACTANT - EMULSIF…

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CETYL PHOSPHATE appears in the CosIng inventory

The CosIng inventory lists CETYL PHOSPHATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CETYL PHOSPHATE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CETYL PHOSPHATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CETYL PHOSPHATE carries the following function designation(s):

CAS 3539-43-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for CETYL PHOSPHATE

This page reproduces the CosIng inventory entry for CETYL PHOSPHATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CETYL PHOSPHATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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