Is ARGININE PCA safe to use in EU cosmetics?

ARGININE PCA is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

How do I check if my formula contains ARGININE PCA?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 7432015/10/2010

ARGININE PCA

5-oxo-L-proline, compound with L-arginine (1:1)

ARGININE PCA is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 56265-06-6

CAS 56265-06-6PubChem CID 198346

Arginine PCA

IUPAC name: (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;(2S)-5-oxopyrrolidine-2-carboxylic acid

Molecular formula: C11H21N5O5
Molecular weight: 303.32 g/mol
Exact mass: 303.15426879 Da
Topological polar surface area: 194.0 Å²
Hydrogen-bond donors: 6
Hydrogen-bond acceptors: 7
Covalent units: 2
Defined stereocentres: 2

Also known as

Arginine pidolateAdiuvantEINECS 260-081-5ARGIDONE808T94CEU65-Oxo-L-proline, compound with L-arginine (1:1)ARGININE L-PYROGLUTAMATEL-ARGININE L-2 PYRROLIDONE-5-CARBOXYLATE

16 more reported names

RefChem:559943ARGININE PCA [INCI]L-arginine L-2-pyrrolidone-5-carboxylateL-Arginine-L-pyroglutamateL-Arginine L-Pyroglutamate5-Oxo-L-proline L-arginine saltC11H21N5O5Arginina pidolatoArginina pidolato [Spanish]UNII-808T94CEU65-oxo-Pro-OH H-Arg-OH salt5-Oxo-L-proline--L-arginine (1/1)ARGININE PYROGLUTAMATE [WHO-DD]AS-46926CS-0187166L-Arginine-L-pyroglutamate (H-L-Arg-OH.H-L-Pyr-OH)

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External database identifiers

EPA DTXSID:DTXSID50971695

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 64855-91-0

CAS 64855-91-0PubChem CID 6454976

Pyrglutargine

IUPAC name: (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;5-oxopyrrolidine-2-carboxylic acid

Molecular formula: C11H21N5O5
Molecular weight: 303.32 g/mol
Exact mass: 303.15426879 Da
Topological polar surface area: 194.0 Å²
Hydrogen-bond donors: 6
Hydrogen-bond acceptors: 7
Covalent units: 2
Defined stereocentres: 1

Also known as

Arginine pyroglutamateVYI1WK838BRefChem:1097252PirglutarginaUNII-VYI1WK838BEINECS 265-253-35-Oxo-DL-proline, compound with L-arginine (1:1)G-278

8 more reported names

C11H21N5O5PIRGLUTARGINEPIRGLUTARGINE [MART.]PIRGLUTARGINE [WHO-DD]L-ARGININE DL-PYROGLUTAMATEAS-12651N~5~-(Diaminomethylidene)-L-ornithine--5-oxoproline (1/1)(2S)-2-amino-5-guanidino-pentanoic acid;5-oxopyrrolidine-2-carboxylic acid

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID90215141

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ARGININE PCA

INCI name

ARGININE PCA

Description

5-oxo-L-proline, compound with L-arginine (1:1)

Record provenance

Inventory reference: 74320
Imported identity: ARGININE PCA
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for ARGININE PCA

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Key data

CAS

56265-06-6 / 64855-91-0

260-081-5 / 265-253-3

Restriction

—

Function

HUMECTANT: Retaining and/or preserving the moisture in a product during use.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#2254 · ARGININE PCA

Ingredients with overlapping formulation functions

ARGANIA SPINOSA CALLUS EXTRACTANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN PROTECTING

ARGANIA SPINOSA KERNEL OIL/HYDROGENATED ARGANIA SPINOSA KERNEL OIL ESTERSHUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

ARGANIA SPINOSA SEEDCAKE EXTRACTHUMECTANT

ARGILLAABRASIVE, BULKING, HUMECTANT

ARISTOTELIA CHILENSIS SEED OILHUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

ARTEMISIA ANNUA OILANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

ARTEMISIA CARUIFOLIA POWDERABRASIVE, FRAGRANCE, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

ARTEMISIA FUKUDO EXTRACTHUMECTANT, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ARGININE PCA appears in the CosIng inventory

The CosIng inventory lists ARGININE PCA as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ARGININE PCA is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ARGININE PCA is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ARGININE PCA carries the following function designation(s):

CAS 56265-06-6 / 64855-91-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for ARGININE PCA

This page reproduces the CosIng inventory entry for ARGININE PCA from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ARGININE PCA and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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