Is PROPANEDIOL safe to use in EU cosmetics?

PROPANEDIOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

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InventoryRef 5839215/10/2010

PROPANEDIOL

1,3-dihydroxypropane

PROPANEDIOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 26264-14-2

CAS 26264-14-2PubChem CID 134919

Propanediol

IUPAC name: propane-1,1-diol

Molecular formula: C3H8O2
Molecular weight: 76.09 g/mol
Exact mass: 76.052429494 Da
XLogP3: -0.3
Topological polar surface area: 40.5 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

PropandiolRefChem:9087Coupling Lavender Relax Premium massagelotionCoupling Chamomile Relax Premium massagelotion1,3-PROPANEDIOL (USP-RS)FEMA NO. 4753NSC-65426Propanediol (8CI,9CI)

4 more reported names

n-propandiolpropane diolSCHEMBL5210SCHEMBL5211

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID9074939
PubMed:22547662
PubMed:22248800
PubMed:22174711
PubMed:21754432
PubMed:21754431
PubMed:21699137
PubMed:21456637
PubMed:21384134
PubMed:20873808
PubMed:20573275
PubMed:20518517
PubMed:20155751

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 504-63-2

CAS 504-63-2PubChem CID 10442

1,3-Propanediol

Propane-1,3-diol is the simplest member of the class of propane-1,3-diols, consisting of propane in which one hydrogen from each methyl group is substituted by a hydroxy group. A colourless, viscous, water-miscible liquid with a high (210C) boiling point, it is used in the synthesis of certain polymers and as a solvent and antifreeze. It has a role as a metabolite and a protic solvent. — ChEBI

IUPAC name: propane-1,3-diol

Molecular formula: C3H8O2
Molecular weight: 76.09 g/mol
Exact mass: 76.052429494 Da
XLogP3: -1.0
Topological polar surface area: 40.5 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

Trimethylene glycol1,3-Dihydroxypropane1,3-Propylene glycol2-Deoxyglycerol1,3-Propylenediolbeta-Propylene glycol2-(Hydroxymethyl)ethanolomega-Propanediol

16 more reported names

5965N8W85TCHEBI:16109RefChem:906914207-997-31,3-PROPANDIOL.beta.-Propylene glycolNSC 65426.omega.-PropanediolAI3-01851HOCH2CH2CH2OHHO(CH2)3OHEINECS 207-997-3BRN 0969155UNII-5965N8W85T3-hydroxypropanol1,3 propanediol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:16109
ChEMBL:CHEMBL379652
EPA DTXSID:DTXSID8041246
PubMed:22940336
PubMed:22884211
PubMed:22867840
PubMed:22855718
PubMed:22855717
PubMed:22830705
PubMed:22809320
PubMed:22808739
PubMed:22803399
PubMed:22752794
PubMed:22734778
PubMed:22728193

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PROPANEDIOL

INCI name

PROPANEDIOL

Description

1,3-dihydroxypropane

Record provenance

Inventory reference: 58392
Imported identity: PROPANEDIOL
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PROPANEDIOL

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Key data

CAS

504-63-2 / 26264-14-2

207-997-3

Restriction

—

Function

SOLVENT: Dissolving other components of cosmetics. Solvents are usually liquids (aqueous and nonaqueous).
VISCOSITY CONTROLLING: Increasing or decreasing the viscosity (thickness) of cosmetics.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#23262 · PROPANEDIOL

Ingredients with overlapping formulation functions

PPG-7SKIN CONDITIONING, SOLVENT

PPG-7-BUTETH-10HAIR CONDITIONING, SKIN CONDITIONING, SOLVENT

PPG-7-BUTETH-4HAIR CONDITIONING, SKIN CONDITIONING, SOLVENT

PPG-70 GLYCERYL ETHERSKIN CONDITIONING - EMOLLIENT, SOLVENT

PROPANEDIOL DICAPRYLATESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT

PROPYL ACETATEPERFUMING, SOLVENT

PROPYL ALCOHOLANTIFOAMING, SOLVENT

PROPYL TRIMETHICONEHUMECTANT, SKIN CONDITIONING, SOLVENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PROPANEDIOL appears in the CosIng inventory

The CosIng inventory lists PROPANEDIOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PROPANEDIOL is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PROPANEDIOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PROPANEDIOL carries the following function designation(s):

CAS 504-63-2 / 26264-14-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for PROPANEDIOL

This page reproduces the CosIng inventory entry for PROPANEDIOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PROPANEDIOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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