What does the restriction note for PROGESTERONE mean?

The restriction field for PROGESTERONE reads: II/194. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 57-83-0?

CAS 57-83-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains PROGESTERONE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5838915/10/2010

PROGESTERONE

Pregn-4-ene-3,20-dione; 17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione

PROGESTERONE is linked to 1 EU annex record on this page. Inventory note: II/194.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 57-83-0

CAS 57-83-0PubChem CID 5994

Progesterone

Progesterone is a white powder. Melting point 121 °C. Stable in air. Insoluble in water. A female sex hormone. Low toxicity. — CAMEO Chemicals

IUPAC name: (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

Molecular formula: C21H30O2
Molecular weight: 314.5 g/mol
Exact mass: 314.224580195 Da
XLogP3: 3.9
Topological polar surface area: 34.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 6

Also known as

Pregn-4-ene-3,20-dioneAgolutinProgestinCrinoneUtrogestanLuteolGestormoneGlanducorpin

16 more reported names

SyngesteroneCyclogestGestone4-Pregnene-3,20-dioneCorlutinaCorluviteFlavolutanFologenonGynolutoneHormoflaveineHormolutonLucorteumLuteostabLutociclinaLutocyclinPregnenedione

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:17026
ChEMBL:CHEMBL103
EPA DTXSID:DTXSID3022370
PubMed:40216312
PubMed:38992643
PubMed:37087062
PubMed:37009741
PubMed:34768887
PubMed:34627990
PubMed:34181028
PubMed:34019995
PubMed:33814510
PubMed:33728745
PubMed:33638691
PubMed:33405908

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PROGESTERONE

INCI name

PROGESTERONE

INN name

progesterone

Description

Pregn-4-ene-3,20-dione; 17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione

Record provenance

Inventory reference: 58389
Imported identity: PROGESTERONE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PROGESTERONE

Annex II Restriction reference

Entry 194

Progestogens

Key data

CAS

57-83-0

200-350-6

Restriction

II/194

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#23251 · PROGESTERONE

Ingredients with overlapping formulation functions

PRINSEPIA UTILIS SEED EXTRACTASTRINGENT, HAIR CONDITIONING, SKIN CONDITIONING

PRINSEPIA UTILIS SEED OILSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

PRISTANESKIN CONDITIONING

PROCOLLAGENHAIR CONDITIONING, SKIN CONDITIONING

PROLINEHAIR CONDITIONING, SKIN CONDITIONING

PROLYL HISTAMINE HCLSKIN CONDITIONING

PROMICROMONOSPORA FERMENT FILTRATEHUMECTANT, SKIN CONDITIONING

PROPAGERMANIUMSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PROGESTERONE appears in the CosIng inventory

The CosIng inventory lists PROGESTERONE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PROGESTERONE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PROGESTERONE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for PROGESTERONE reads: "II/194". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, PROGESTERONE carries the following function designation(s):

SKIN CONDITIONING

CAS 57-83-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PROGESTERONE

This page combines the CosIng inventory entry for PROGESTERONE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research PROGESTERONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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