What does the restriction note for PRAMOXINE HCL mean?

The restriction field for PRAMOXINE HCL reads: II/405. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 637-58-1?

CAS 637-58-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains PRAMOXINE HCL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5838515/10/2010

PRAMOXINE HCL

Morpholine, 4-[3-(4-butoxyphenoxy)-propyl]-, hydrochloride

PRAMOXINE HCL is linked to 1 EU annex record on this page. Inventory note: II/405.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 637-58-1

CAS 637-58-1PubChem CID 73957

Pramoxine Hydrochloride

Pramoxine hydrochloride is an aromatic ether. — ChEBI

IUPAC name: 4-[3-(4-butoxyphenoxy)propyl]morpholine;hydrochloride

Molecular formula: C17H28ClNO3
Molecular weight: 329.9 g/mol
Exact mass: 329.1757714 Da
Topological polar surface area: 30.9 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 4
Covalent units: 2
Defined stereocentres: 0

Also known as

Pramoxine HClPramocaine hydrochlorideTronothaneNSC-25573Walgreen Anti-ItchPramoxine hydrochloride [USP]88AYB867L54-(3-(p-Butoxyphenoxy)propyl)morpholine hydrochloride

16 more reported names

4-[3-(p-Butoxyphenoxy)propyl]morpholine hydrochloridePramoxine hydrochloride (USP)CVS Health Maximum Strength FeminineCurasoreReesesDermal-SootheProctofoam NSSuffusion PHoney PotPramoxine HCIIvy WashPoison Ivy WashDeter-XPramox-1Comfort ConditionerPramox Creme rinse

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:8358
ChEMBL:CHEMBL1201171
EPA DTXSID:DTXSID2047777
PubMed:1313

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PRAMOXINE HCL

INCI name

PRAMOXINE HCL

Description

Morpholine, 4-[3-(4-butoxyphenoxy)-propyl]-, hydrochloride

Record provenance

Inventory reference: 58385
Imported identity: PRAMOXINE HCL
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PRAMOXINE HCL

Annex II Restriction reference

Entry 405

Pramocaine (INN)

CAS: 140-65-8

EC: 205-425-7

Key data

CAS

637-58-1

211-293-1

Restriction

II/405

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#23231 · PRAMOXINE HCl

Ingredients with overlapping formulation functions

PPG-30 TOCOPHERETH-70ANTIOXIDANT, BINDING, SKIN CONDITIONING, SURFACTANT - CLEANSING

PPG-5 TOCOPHERETH-2ANTICAKING, ANTIOXIDANT, BINDING

PPG-5 TOCOPHERYL ETHERANTICAKING, ANTIOXIDANT, SKIN CONDITIONING

PPG-70 TOCOPHERETH-100ANTICAKING, ANTIOXIDANT, SKIN CONDITIONING

PROPANOYLRESORCINOLANTIOXIDANT

PROPYL GALLATEANTIOXIDANT, PERFUMING

PROPYL GRAPEVINE SHOOT EXTRACT OLIVATEANTIOXIDANT, SKIN PROTECTING

PROPYL OLEOYL GRAPE SEED EXTRACTANTIOXIDANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PRAMOXINE HCL appears in the CosIng inventory

The CosIng inventory lists PRAMOXINE HCL as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PRAMOXINE HCL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PRAMOXINE HCL appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for PRAMOXINE HCL reads: "II/405". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, PRAMOXINE HCL carries the following function designation(s):

ANTIOXIDANT

CAS 637-58-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PRAMOXINE HCL

This page combines the CosIng inventory entry for PRAMOXINE HCL with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research PRAMOXINE HCL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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