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CAS 45103-58-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 5803315/10/2010

METHOXYDIGLYCOL METHACRYLATE

2-Propenoic acid, 2-Methyl-, 2-(2-Methoxyethoxy)Ethyl Ester

METHOXYDIGLYCOL METHACRYLATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 45103-58-0

CAS 45103-58-0PubChem CID 170752

2-(Methoxyethoxy)ethyl methacrylate

Based on available data, the CIR Expert Panel concluded that... Methoxydiglycol Methacrylate is safe as used in nail enhancement products when skin contact is avoided. Products containing these ingredients should be accompanied with directions to avoid skin contact, because of the sensitizing potential of Methacrylates. — Cosmetic Ingredient Review (CIR)

IUPAC name: 2-(2-methoxyethoxy)ethyl 2-methylprop-2-enoate

Molecular formula: C9H16O4
Molecular weight: 188.22 g/mol
Exact mass: 188.10485899 Da
XLogP3: 0.9
Topological polar surface area: 44.8 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

2-(2-Methoxyethoxy)ethyl methacrylateMethoxydiglycol methacrylateMDM cpd2-Propenoic acid, 2-methyl-, 2-(2-methoxyethoxy)ethyl ester0548T81DSOBLEMMER PME 100NK ESTER M 20GRefChem:461184

16 more reported names

256-190-2Diethylene glycol monomethyl ether methacrylateDi(ethylene glycol) methyl ether methacrylateMethyl Carbitol Methacrylate2-(2-methoxyethoxy)ethylmethacrylateMETHOXYETHOXYETHYL METHACRYLATEDiethylene Glycol Monomethyl Ether Methacrylate (stabilized with MEHQ)UNII-0548T81DSOEINECS 256-190-2Methacrylic Acid 2-(2-Methoxyethoxy)ethyl EsterBS-22734CS-0204643D15312-(2-Methoxyethoxy)ethyl 2-methylacrylate #EN300-1704831Di(ethylene glycol) methyl ether methacrylate, 95%

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID8068464
PubMed:22437547
PubMed:22431284
PubMed:22336325
PubMed:22163636
PubMed:21967746
PubMed:21480424
PubMed:21366333
PubMed:21174426
PubMed:21162088
PubMed:21131046
PubMed:20839794
PubMed:20690720

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for METHOXYDIGLYCOL METHACRYLATE

INCI name

METHOXYDIGLYCOL METHACRYLATE

Description

2-Propenoic acid, 2-Methyl-, 2-(2-Methoxyethoxy)Ethyl Ester

Record provenance

Inventory reference: 58033
Imported identity: METHOXYDIGLYCOL METHACRYLATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for METHOXYDIGLYCOL METHACRYLATE

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Key data

CAS

45103-58-0

256-190-2

Restriction

—

Function

FILM FORMING: Producing (upon application) a continuous film on the skin, hair or nails.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#16424 · METHOXYDIGLYCOL METHACRYLATE

Ingredients with overlapping formulation functions

METHOXY PEG-114/POLYEPSILON CAPROLACTONEBUFFERING, FILM FORMING, HAIR CONDITIONING

METHOXY PEG-9 METHACRYLATEFILM FORMING, HUMECTANT, SKIN CONDITIONING

METHOXYCINNAMIDOPROPYL DIMETHYLAMINOBENZAMIDOPROPYL DIMETHICONOLANTIOXIDANT, FILM FORMING, LIGHT STABILIZER, SKIN CONDITIONING - EMOLLIENT

METHOXYCINNAMIDOPROPYL/PHENYL POLYSILSESQUIOXANEANTIOXIDANT, FILM FORMING, LIGHT STABILIZER, SKIN CONDITIONING, SKIN PROTECTING

METHOXYETHYL ACRYLATEFILM FORMING

METHOXYPOLYOXYMETHYLENE MELAMINEBINDING, FILM FORMING

METHYL DIETHANOLAMINEFILM FORMING

METHYL EPOXIDIZED SOYATEFILM FORMING, PLASTICISER

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How METHOXYDIGLYCOL METHACRYLATE appears in the CosIng inventory

The CosIng inventory lists METHOXYDIGLYCOL METHACRYLATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

METHOXYDIGLYCOL METHACRYLATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

METHOXYDIGLYCOL METHACRYLATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, METHOXYDIGLYCOL METHACRYLATE carries the following function designation(s):

FILM FORMING

CAS 45103-58-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for METHOXYDIGLYCOL METHACRYLATE

This page reproduces the CosIng inventory entry for METHOXYDIGLYCOL METHACRYLATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research METHOXYDIGLYCOL METHACRYLATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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