Is LACCASE safe to use in EU cosmetics?

LACCASE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 80498-15-3?

CAS 80498-15-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains LACCASE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5783915/10/2010

LACCASE

Laccase is an enzyme produced by fermentation of Aspergillus oryzae expressing the gene encoding a laccase from Myceliophthora thermophila

LACCASE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 80498-15-3

CAS 80498-15-3PubChem CID 3153309

Laccase

IUPAC name: 1-ethyl-2,5-dimethylpyrrole-3-carbaldehyde

Molecular formula: C9H13NO
Molecular weight: 151.21 g/mol
Exact mass: 151.099714038 Da
XLogP3: 1.2
Topological polar surface area: 22.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

Denilase II SUrushiol oxidaseNovozyme 809urishiol oxidaseOxidase, Urishiolp Diphenol OxidaseOxidase, p-DiphenolSP 504

10 more reported names

RefChem:798342EC 420-150-4E.C. 1.10.3.2420-150-4617-092-91-Ethyl-2,5-dimethyl-1H-pyrrole-3-carbaldehyde1-ethyl-2,5-dimethyl-pyrrole-3-carbaldehydeDB-363579CS-0257712EN300-67599

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External database identifiers

EPA DTXSID:DTXSID40390018

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for LACCASE

INCI name

LACCASE

Description

Laccase is an enzyme produced by fermentation of Aspergillus oryzae expressing the gene encoding a laccase from Myceliophthora thermophila

Record provenance

Inventory reference: 57839
Imported identity: LACCASE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for LACCASE

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Key data

CAS

80498-15-3

420-150-4

Restriction

—

Function

OXIDISING: Changing the chemical nature of another ingredient by adding oxygen (or removing hydrogen).

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#14261 · LACCASE

Ingredients with overlapping formulation functions

DIMETHYL HEXAHYDROXYDIPHENATEHAIR CONDITIONING; OXIDISING; SKIN PROTECTING; SKIN CONDITIONING - MISCELLANEOUS

HYDROGEN PEROXIDEANTIMICROBIAL, ORAL CARE, OXIDISING

HYPOCHLOROUS ACIDANTI-SEBUM, ANTIMICROBIAL, DEODORANT, OXIDISING

IPOMOEA BATATAS ROOT POWDEROXIDISING, SKIN CONDITIONING

LINDERA ERYTHROCARPA EXTRACTOXIDISING

MAGNESIUM PEROXIDEOXIDISING

MELAMINE PEROXIDEOXIDISING

NIOBIUM PENTOXIDEANTI-SEBORRHEIC; ANTIMICROBIAL; ANTI-SEBUM; DEODORANT; ORAL CARE; OXIDISING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How LACCASE appears in the CosIng inventory

The CosIng inventory lists LACCASE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

LACCASE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

LACCASE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, LACCASE carries the following function designation(s):

OXIDISING

CAS 80498-15-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for LACCASE

This page reproduces the CosIng inventory entry for LACCASE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research LACCASE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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