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InventoryRef 5732215/10/2010

NARINGIN

4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (S)-

NARINGIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 10236-47-2
CAS 10236-47-2PubChem CID 442428

Naringin

Naringin is a disaccharide derivative that is (S)-naringenin substituted by a 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent. It is a member of 4'-hydroxyflavanones, a (2S)-flavan-4-one, a neohesperidoside, a dihydroxyflavanone and a disaccharide derivative. It is functionally related to a (S)-naringenin. — ChEBI

IUPAC name
(2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
Molecular formula
C27H32O14
Molecular weight
580.5 g/mol
Exact mass
580.17920569 Da
XLogP3
-0.5
Topological polar surface area
225.0 Ų
Hydrogen-bond donors
8
Hydrogen-bond acceptors
14
Covalent units
1
Defined stereocentres
11

Also known as

aurantiinNaringosideNaringenin 7-O-neohesperidosideN7TD9J649BNaringenin-7-beta-neohesperidosideCHEBI:288195-Hydroxy-2-(4-hydroxyphenyl)-7-(2-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyloxy)-4-chromanonNaringenin 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside]
16 more reported names
4',5,7-trihydroxyflavanone 7-rhamnoglucosideNaringenin 7-O-(alpha-L-rhamnosyl-(1->2)-beta-D-glucoside)Citrus naringinineNaringenin GlycosideRefChem:6054naringenin-7-hesperidoside233-566-4Naringin (Standard)Naringenin 7-Rhamnoglucoside4'5-diOH-Flavone-7-rhgluc(s)-yranosyl]oxy]-(2S)-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1-benzopyran-7-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside(2S)-NaringinSR-01000736681UNII-N7TD9J649BNaringin CRS
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:28819

naringin

A disaccharide derivative that is (S)-naringenin substituted by a 2-O-(α-L-rhamnopyranosyl)-β-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.

Formula
C27H32O14
Average mass
580.539 g/mol
Monoisotopic mass
580.17921 Da
Formal charge
0
  • (2S)-flavan-4-one — is a (CHEBI:140377)
  • 4'-hydroxyflavanones — is a (CHEBI:140331)
  • disaccharide derivative — is a (CHEBI:63353)
  • dihydroxyflavanone — is a (CHEBI:38749)
  • neohesperidoside — is a (CHEBI:25495)
  • metabolite — has role (CHEBI:25212)
  • antineoplastic agent — has role (CHEBI:35610)
  • anti-inflammatory agent — has role (CHEBI:67079)
  • (S)-naringenin — has functional parent (CHEBI:17846)
  • metabolite — has role (CHEBI:25212)
  • antineoplastic agent — has role (CHEBI:35610)
  • anti-inflammatory agent — has role (CHEBI:67079)
  • (2S)-flavan-4-one — is a (CHEBI:140377)
  • 4'-hydroxyflavanones — is a (CHEBI:140331)
  • disaccharide derivative — is a (CHEBI:63353)
  • dihydroxyflavanone — is a (CHEBI:38749)
  • neohesperidoside — is a (CHEBI:25495)
Additional curated names
(2S)-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosideNaringenin 7-O-alpha-L-rhamnosyl-(1->2)-beta-D-glucosideNaringenin 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside]Naringenin 7-O-neohesperidosideNaringinNaringoside
Cross-references from this source
  • REGISTRY_NUMBER: 102012 — Reaxys
  • CAS: 10236-47-2 — KEGG COMPOUND
  • CAS: 10236-47-2 — ChemIDplus
  • MANUAL_X_REF: C00000983 — KNApSAcK
  • MANUAL_X_REF: C09789 — KEGG COMPOUND
  • MANUAL_X_REF: HMDB0002927 — HMDB
  • MANUAL_X_REF: LSM-2038 — LINCS
  • MANUAL_X_REF: Naringin — Wikipedia
  • MANUAL_X_REF: NARINGIN — MetaCyc

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2018-04-09. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match442428

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 76.1% (143 of 188) of all reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (23.9%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (23.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (23.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 188 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 143 of 188 reports by companies.; There are 6 notifications provided by 45 of 188 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NARINGIN

INCI name

NARINGIN

Description

4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (S)-

Record provenance

Inventory reference
57322
Imported identity
NARINGIN
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
10236-47-2
EC
233-566-4
Restriction
—
Function
SKIN PROTECTING
Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17256 · NARINGIN

Ingredients with overlapping formulation functions

NARCISSUS JONQUILLA CALLUS EXTRACTANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING
NARCISSUS POETICUS CALLUS EXTRACTANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING
NARCISSUS POETICUS EXTRACTSKIN PROTECTING
NARCISSUS TAZETTA STEM EXTRACTSKIN PROTECTING
NAUCLEA ORIENTALIS CALLUS EXTRACTANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING
NELUMBO NUCIFERA CALLUSANTI-SEBUM, ANTIFOAMING, ANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, HAIR CONDITIONING, SKIN PROTECTING
NELUMBO NUCIFERA LEAF CELL CULTURE POWDERSKIN PROTECTING
NELUMBO NUCIFERA LEAF CELL EXTRACTSKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How NARINGIN appears in the CosIng inventory

The CosIng inventory lists NARINGIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NARINGIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NARINGIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NARINGIN carries the following function designation(s):

CAS 10236-47-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for NARINGIN

This page reproduces the CosIng inventory entry for NARINGIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NARINGIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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