Is PEG-450 safe to use in EU cosmetics?

PEG-450 is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 25322-68-3?

CAS 25322-68-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains PEG-450?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5686524/01/2011

PEG-450

Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy- (450 mol EO average molar ratio)

PEG-450 is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Exact external identity check

not_found

No complete-name PubChem match was verified. The material may be a mixture, trade-style INCI identity or be indexed under another identifier; this result must not be read as proof that no related chemistry exists.

Exact CosIng INCI name equals a PubChem synonym · Checked 2026-08-31

Inventory details for PEG-450

INCI name

PEG-450

Description

Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy- (450 mol EO average molar ratio)

Record provenance

Inventory reference: 56865
Imported identity: PEG-450
Source update: 24/01/2011

European Commission CosIng source notes

Annex records for PEG-450

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Key data

CAS

25322-68-3

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Restriction

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Function

BINDING: Providing adhesive properties during and after compression in cosmetic tablets and/or cakes.
EMULSION STABILISING: Helping the process of emulsification and improving emulsion stability and shelf-life.
SOLVENT: Dissolving other components of cosmetics. Solvents are usually liquids (aqueous and nonaqueous).

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#19884 · PEG-450

Records sharing a CAS or EC identity

PEG-10 PEG-100 PEG-115M PEG-12 PEG-135 PEG-14 PEG-14M PEG-150

Ingredients with overlapping formulation functions

PEG-4 DIMETHACRYLATEBINDING, FILM FORMING

PEG-4 MONTANATEBINDING, SURFACTANT - EMULSIFYING, VISCOSITY CONTROLLING

PEG-400BINDING, EMULSION STABILISING, SOLVENT

PEG-45BINDING, HUMECTANT, SOLVENT

PEG-5 PENTAERYTHRITYL DIMETHYLOL PROPIONATE-2 DENDRIMERABSORBENT, BINDING, EMULSION STABILISING, FILM FORMING, HAIR FIXING

PEG-5 PENTAERYTHRITYL DIMETHYLOL PROPIONATE-3 DENDRIMERABSORBENT, BINDING, EMULSION STABILISING, FILM FORMING, HAIR FIXING

PEG-5 PENTAERYTHRITYL DIMETHYLOL PROPIONATE-4 DENDRIMERABSORBENT, BINDING, EMULSION STABILISING, FILM FORMING, HAIR FIXING

PEG-500BINDING, EMULSION STABILISING, SOLVENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PEG-450 appears in the CosIng inventory

The CosIng inventory lists PEG-450 as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PEG-450 is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PEG-450 is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PEG-450 carries the following function designation(s):

CAS 25322-68-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PEG-450

This page reproduces the CosIng inventory entry for PEG-450 from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PEG-450 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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