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CAS 989-51-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 5614815/10/2010

EPIGALLOCATECHIN GALLATE

Benzoic acid, 3,4,5-trihydroxy, (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester

EPIGALLOCATECHIN GALLATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 989-51-5

CAS 989-51-5PubChem CID 65064

Epigallocatechin Gallate

(-)-epigallocatechin 3-gallate is a gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of ()-epigallocatechin. It has a role as a geroprotector, an antioxidant, an antineoplastic agent, a neuroprotective agent, a Hsp90 inhibitor, an apoptosis inducer and a plant metabolite. It is a polyphenol, a gallate ester and a member of flavans. It is functionally related to a (-)-epigallocatechin. — ChEBI

IUPAC name: [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate

Molecular formula: C22H18O11
Molecular weight: 458.4 g/mol
Exact mass: 458.08491139 Da
XLogP3: 1.2
Topological polar surface area: 197.0 Å²
Hydrogen-bond donors: 8
Hydrogen-bond acceptors: 11
Covalent units: 1
Defined stereocentres: 2

Also known as

(-)-Epigallocatechin gallateEGCGEpigallocatechin-3-gallateTea catechin(-)-Epigallocatechin-3-o-gallateTeavigo(-)-Epigallocatechol gallateL-Epigallocatechin gallate

16 more reported names

PF-EGCg 90EpigallocatechingallateNVP-XAA 723BQM438CTELepigallocatechin-3-O-gallate(-)-Epigallocatechin-3-gallateEpigallocatechin-gallateEPIGALLOCATECHIN 3-O-GALLATECHEBI:4806(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate3-O-Galloyl-(-)-epigallocatechinEGCG cpdepigallo-catechin gallateRefChem:5796((2R,3R)-2-(3,4,5-trihydroxyphenyl)-5,7-dihydroxy-chroman-3-yl) 3,4,5-trihydroxybenzoate((2S,3S)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl) 3,4,5-trihydroxybenzoate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:4806
ChEMBL:CHEMBL297453
EPA DTXSID:DTXSID1029889
PubMed:40348029
PubMed:40086586
PubMed:39667565
PubMed:39577827
PubMed:39322001
PubMed:39313106
PubMed:39299375
PubMed:38833985
PubMed:38146662
PubMed:37797956
PubMed:37353134
PubMed:37286014

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for EPIGALLOCATECHIN GALLATE

INCI name

EPIGALLOCATECHIN GALLATE

Description

Benzoic acid, 3,4,5-trihydroxy, (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester

Record provenance

Inventory reference: 56148
Imported identity: EPIGALLOCATECHIN GALLATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for EPIGALLOCATECHIN GALLATE

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Key data

CAS

989-51-5

—

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#9864 · EPIGALLOCATECHIN GALLATE

Ingredients with overlapping formulation functions

ENTEROCOCCUS FAECALIS/AMYLASE/GLUCOSE/PAPAYA FRUIT/PROTEASE FERMENT FILTRATEANTIOXIDANT

ENTEROCOCCUS FAECIUM/LAETIPORUS SULPHUREUS MYCELIUM/POLYGONUM CUSPIDATUM ROOT E…ANTIOXIDANT

ENTEROCOCCUS ROTAI EXTRACELLULAR VESICLESANTIMICROBIAL; ANTIOXIDANT; SKIN PROTECTING

EPICATECHINANTIOXIDANT; ASTRINGENT; DEODORANT; HAIR DYEING; ORAL CARE; SKIN PROTECTING; SKIN CONDITIONING - MI…

EPIGALLOCATECHIN GALLATYL GLUCOSIDEANTIOXIDANT, SKIN CONDITIONING

EPIMEDIUM SAGITTATUM LEAF/STEM EXTRACTANTIOXIDANT, FLAVOURING

EQUISETUM FLUVIATILE EXTRACTANTIOXIDANT

EQUOLANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How EPIGALLOCATECHIN GALLATE appears in the CosIng inventory

The CosIng inventory lists EPIGALLOCATECHIN GALLATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

EPIGALLOCATECHIN GALLATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

EPIGALLOCATECHIN GALLATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, EPIGALLOCATECHIN GALLATE carries the following function designation(s):

ANTIOXIDANT

CAS 989-51-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for EPIGALLOCATECHIN GALLATE

This page reproduces the CosIng inventory entry for EPIGALLOCATECHIN GALLATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

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