Is CYTIDINE safe to use in EU cosmetics?

CYTIDINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 65-46-3?

CAS 65-46-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains CYTIDINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5557415/10/2010

CYTIDINE

4-Amino-1-β-D-Ribofuranosyl-2-(1H)-Pyrimidinone

CYTIDINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 65-46-3

CAS 65-46-3PubChem CID 6175

Cytidine

Cytidine is a pyrimidine nucleoside in which cytosine is attached to ribofuranose via a beta-N1-glycosidic bond. It has a role as a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a human metabolite. It is functionally related to a cytosine. — ChEBI

IUPAC name: 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

Molecular formula: C9H13N3O5
Molecular weight: 243.22 g/mol
Exact mass: 243.08552052 Da
XLogP3: -2.1
Topological polar surface area: 129.0 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 4

Also known as

Cytosine riboside4-Amino-1-beta-D-ribofuranosyl-2(1H)-pyrimidinone1-beta-D-Ribofuranosylcytosinebeta-D-Ribofuranoside, cytosine-11beta-D-Ribofuranosylcytosine4-Amino-1beta-D-ribofuranosyl-2(1H)-pyrimidinone2(1H)-Pyrimidinone, 4-amino-1-beta-D-ribofuranosyl-5CSZ8459RP

16 more reported names

CHEBI:17562NSC-202584-amino-1-beta-D-ribofuranosylpyrimidin-2(1H)-one4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-oneRiboside, CytosineCytosine RibonucleosideRibonucleoside, Cytosine4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)pyrimidin-2-one4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-1,2-dihydropyrimidin-2-oneRefChem:388908200-610-91beta-Ribofuranosylcytosine1-beta-RibofuranosylcytosineCytidinCytosine, 1-beta-D-ribofuranosyl-1beta-2'-Ribofuranosylcytosine, d-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:17562
ChEMBL:CHEMBL95606
EPA DTXSID:DTXSID60891552
PubMed:31066272
PubMed:27469509
PubMed:23111733
PubMed:23089878
PubMed:23086289
PubMed:23072506
PubMed:23037308
PubMed:23001034
PubMed:23001005
PubMed:22988838
PubMed:22978342
PubMed:22976982

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CYTIDINE

INCI name

CYTIDINE

Description

4-Amino-1-β-D-Ribofuranosyl-2-(1H)-Pyrimidinone

Record provenance

Inventory reference: 55574
Imported identity: CYTIDINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for CYTIDINE

Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search annex entries

Search the annex database for entries matching CYTIDINE or related substances.

Key data

CAS

65-46-3

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#7994 · CYTIDINE

Ingredients with overlapping formulation functions

CYPERUS MICROIRIA EXTRACTSKIN CONDITIONING - EMOLLIENT; HAIR CONDITIONING; HUMECTANT; SKIN PROTECTING

CYPERUS PAPYRUS LEAF CELL EXTRACTANTIOXIDANT, SKIN PROTECTING

CYSTEINYL TRIPEPTIDE-35ANTI-SEBUM, ANTIOXIDANT, CHELATING, SKIN PROTECTING

CYSTOSEIRA CAESPITOSA EXTRACTSKIN PROTECTING

DAEDALEA DICKINSII MYCELIUM EXTRACT FILTRATEANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

DAEDALEA DICKINSII/HYDROLYZED SALMON OVARY MEMBRANE EXTRACT/SOLUBLE COLLAGEN/SO…HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

DALBERGIA ODORIFERA ROOT EXTRACTSKIN CONDITIONING, SKIN PROTECTING

DAMNACANTHUS MAJOR ADVENTITIOUS ROOT EXTRACTANTIMICROBIAL, ANTIOXIDANT, HUMECTANT, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CYTIDINE appears in the CosIng inventory

The CosIng inventory lists CYTIDINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CYTIDINE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CYTIDINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CYTIDINE carries the following function designation(s):

CAS 65-46-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for CYTIDINE

This page reproduces the CosIng inventory entry for CYTIDINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CYTIDINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect CYTIDINE and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to CYTIDINE, its identifiers or nearby name variants.