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InventoryRef 5476715/10/2010

BIFONAZOLE

1H-IMIDAZOLE, 1-[(1,1'-BIPHENYL)-4-YLPHENYLMETHYL]-

BIFONAZOLE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionSource mapped
Inventory entry; no linked annex rule
0English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandSource mapped
Official source mapped; ingredient rule not imported
0English
ASEANEvidence linked
Prohibited
Open this evidence		1English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 60628-96-8
CAS 60628-96-8PubChem CID 2378

Bifonazole

1-[biphenyl-4-yl(phenyl)methyl]imidazole is a member of the class of imidazoles carrying an alpha-(biphenyl-4-yl)benzyl substituent at position 1. It is a member of biphenyls and a member of imidazoles. — ChEBI

IUPAC name
1-[phenyl-(4-phenylphenyl)methyl]imidazole
Molecular formula
C22H18N2
Molecular weight
310.4 g/mol
Exact mass
310.146998583 Da
XLogP3
4.8
Topological polar surface area
17.8 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

MycosporTrifonazoleBifonazolBAY H 4502BifonazolumBay H-45021-((4-Biphenylyl)phenylmethyl)-1H-imidazole1-(alpha-(4-Biphenylyl)benzyl)imidazole
16 more reported names
Bay-h-4502(+-)-1-(p,alpha-Diphenylbenzyl)imidazoleNSC-758954QYJ305Z91OD01AC101-((4-biphenylyl)-phenylmethyl)-1H-imidazole1H-Imidazole, 1-((1,1'-biphenyl)-4-ylphenylmethyl)-, (+-)-1-(phenyl(4-phenylphenyl)methyl)-1H-imidazole1-[phenyl(4-phenylphenyl)methyl]-1H-imidazolebifonazoloRefChem:568329CHEBI:312861-((RS)-(Biphenyl-4-yl)(phenyl)methyl)-1H-imidazole262-336-6AmycorAzolmen
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for BIFONAZOLE

INCI name

BIFONAZOLE

INN name

BIFONAZOLE

Description

1H-IMIDAZOLE, 1-[(1,1'-BIPHENYL)-4-YLPHENYLMETHYL]-

Record provenance

Inventory reference
54767
Imported identity
BIFONAZOLE
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
60628-96-8
EC
262-336-6
Restriction
—
Function
ANTI-SEBORRHEIC
Preventing or relieving the symptoms of seborrhea and/or seborrheic dermatitis, including dandruff.
ANTIMICROBIAL
Preventing and/or slowing down microbial growth.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#3412 · BIFONAZOLE

Ingredients with overlapping formulation functions

AMINOPROPYL MENTHYL PHOSPHATEANTI-SEBORRHEIC, ANTI-SEBUM, SKIN CONDITIONING
ARTEMISIA ANNUA LEAF EXTRACTANTI-SEBORRHEIC, ANTIMICROBIAL, PERFUMING, SKIN CONDITIONING
ASARUM HETEROTROPOIDES EXTRACTANTI-SEBORRHEIC, ANTIMICROBIAL, ANTIOXIDANT
BETULA ERMANII STEM EXTRACTANTI-SEBORRHEIC, ANTIOXIDANT, ASTRINGENT, HAIR CONDITIONING, SKIN PROTECTING
BLUE SCORPION VENOMANTI-SEBORRHEIC; ANTIOXIDANT; SKIN PROTECTING; NOT REPORTED
BOESENBERGIA PANDURATA RHIZOME EXTRACTANTI-SEBORRHEIC, ANTIMICROBIAL, ANTIOXIDANT, BLEACHING, DEODORANT, HAIR CONDITIONING, HUMECTANT, OR…
BRASSICA CAMPESTRIS FLOWER EXTRACTANTI-SEBORRHEIC, ANTIMICROBIAL, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT
CANDIDA BOMBICOLA/CANOLA OIL FERMENT EXTRACTANTI-SEBORRHEIC, ANTI-SEBUM, ANTIMICROBIAL, PRESERVATIVE, SURFACTANT - CLEANSING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How BIFONAZOLE appears in the CosIng inventory

The CosIng inventory lists BIFONAZOLE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

BIFONAZOLE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

BIFONAZOLE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, BIFONAZOLE carries the following function designation(s):

CAS 60628-96-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for BIFONAZOLE

This page reproduces the CosIng inventory entry for BIFONAZOLE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research BIFONAZOLE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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