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CAS 110102-86-8 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 5422115/10/2010

5-AMINO-4-CHLORO-O-CRESOL

5-Amino-4-chloro-2-methylphenol

5-AMINO-4-CHLORO-O-CRESOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 110102-86-8

CAS 110102-86-8PubChem CID 10176241

5-Amino-4-chloro-o-cresol

The Expert Panel for Cosmetic Ingredient Safety concluded that 5-Amino-4-Chloro-o-Cresol and 5-Amino-4-Chloro-o-Cresol are safe for use as oxidative hair dye ingredients in the present practices of use and concentration described in this safety assessment. — Cosmetic Ingredient Review (CIR)

IUPAC name: 5-amino-4-chloro-2-methylphenol

Molecular formula: C7H8ClNO
Molecular weight: 157.60 g/mol
Exact mass: 157.0294416 Da
XLogP3: 1.9
Topological polar surface area: 46.3 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

Phenol, 5-amino-4-chloro-2-methyl-2-Methyl-4-chloro-5-aminophenol2-Methyl-5-amino-4-chlorophenol3-Amino-4-chloro-6-methylphenol2NX60Y89QX5-Amino-4-chloro-o-cresol [INCI]RefChem:532310UNII-2NX60Y89QX

8 more reported names

5-amino-4-chloro-2-methyl-phenol4-chloro-2-methyl-5-aminophenolWDQMXRWYXILWPT-UHFFFAOYSA-NAS-15896DB-059970CS-0036985EN300-72394405-Amino-4-chloro-o-cresol;2-Methyl-4-chloro-5-aminophenol; 2-Methyl-5-amino-4-chlorophenol; 3-Amino-4-chloro-6-methylphenol; 4-Chloro-5-amino-2-methylphenol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID00149145
PubMed:15513822

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match10176241

Attributed physical-property, hazard, environmental and use annotations.

Cosmetic Ingredient Review Conclusion: The Expert Panel for Cosmetic Ingredient Safety concluded that 5-Amino-4-Chloro-o-Cresol and 5-Amino-4-Chloro-o-Cresol are safe for use as oxidative hair dye ingredients in the present practices of use and concentration described in this safety assessment. Source: Cosmetic Ingredient Review (CIR)
Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)

Cosmetic Ingredient Review Link: CIR ingredient: 5-Amino-4-Chloro-o-Cresol Source: Cosmetic Ingredient Review (CIR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for 5-AMINO-4-CHLORO-O-CRESOL

INCI name

5-AMINO-4-CHLORO-O-CRESOL

Description

5-Amino-4-chloro-2-methylphenol

Record provenance

Inventory reference: 54221
Imported identity: 5-AMINO-4-CHLORO-O-CRESOL
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for 5-AMINO-4-CHLORO-O-CRESOL

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Key data

CAS

110102-86-8

—

Restriction

—

Function

HAIR DYEING: Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#359 · 5-AMINO-4-CHLORO-O-CRESOL

Ingredients with overlapping formulation functions

4-NITRO-O-PHENYLENEDIAMINE SULFATEHAIR DYEING

4-NITROGUAIACOLHAIR DYEING

4-NITROPHENYL AMINOETHYLUREAHAIR DYEING

5-AMINO-2,6-DIMETHOXY-3-HYDROXYPYRIDINEHAIR DYEING

5-AMINO-4-CHLORO-O-CRESOL HCLHAIR DYEING

5-AMINO-4-FLUORO-2-METHYLPHENOL SULFATEHAIR DYEING

5-AMINO-6-CHLORO-O-CRESOLANTIMICROBIAL, HAIR DYEING

5-HYDROXYVANILLINHAIR DYEING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How 5-AMINO-4-CHLORO-O-CRESOL appears in the CosIng inventory

The CosIng inventory lists 5-AMINO-4-CHLORO-O-CRESOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

5-AMINO-4-CHLORO-O-CRESOL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

5-AMINO-4-CHLORO-O-CRESOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, 5-AMINO-4-CHLORO-O-CRESOL carries the following function designation(s):

HAIR DYEING

CAS 110102-86-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for 5-AMINO-4-CHLORO-O-CRESOL

This page reproduces the CosIng inventory entry for 5-AMINO-4-CHLORO-O-CRESOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research 5-AMINO-4-CHLORO-O-CRESOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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