What does the restriction note for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE mean?

The restriction field for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE reads: III/301. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 1603-02-7?

CAS 1603-02-7 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5418413/03/2018

2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE

Q: Is 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE safe to use in EU cosmetics?

2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE appears in the EU CosIng inventory and has linked annex records. Check the annex records for applicable restrictions, concentration limits and conditions of use. Annex II means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

Q: What function does 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE serve in cosmetics?

According to the EU CosIng inventory, 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE carries the following function designation(s): HAIR DYEING.

4-Hydroxy-2,5,6- triaminopyrimidine sulfate

2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE is linked to 1 EU annex record on this page. Inventory note: III/301.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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Market	Evidence status	Records	Source language
European Union	Evidence linked Restricted entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Restricted Open this evidence	1	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Evidence linked Restricted Open this evidence	1	English
ASEAN	Evidence linked Restricted Open this evidence	1	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Evidence linked Restricted Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Restricted Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 1603-02-7

CAS 1603-02-7PubChem CID 74142

4-Pyrimidinol, 2,5,6-triamino-, hydrogen sulfate (ester)

IUPAC name: (2,5,6-triaminopyrimidin-4-yl) hydrogen sulfate

Molecular formula: C4H7N5O4S
Molecular weight: 221.20 g/mol
Exact mass: 221.02187490 Da
XLogP3: -1.8
Topological polar surface area: 176.0 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 9
Covalent units: 1
Defined stereocentres: 0

Also known as

2,5,6-Triaminopyrimidin-4-ol sulphate4-Pyrimidinol, 2,5,6-triamino-, monosulfateEINECS 216-500-9RefChem:526680216-500-92,5,6-triaminopyrimidin-4-yl hydrogen sulfate6-Hydroxy 2,4,5-Triaminopyrimidine SulfateC4H7N5O4S

11 more reported names

(2,5,6-TRIAMINOPYRIMIDIN-4-YL)OXIDANESULFONIC ACID4-Pyrimidinol, 2,5,6-triamino-, hydrogen sulfate (7CI); 4-Pyrimidinol, 2,5,6-triamino-, hydrogen sulfate (ester) (8CI,9CI)2,5,6-Triamino-4-pyrimidinyl Hydrogen SulfateT3YK834X4UDJUGBKWOBAOTFA-UHFFFAOYSA-N97% (contains <10%ammonium salt)AC-24465DS-159172,5,6-triaminopyrimidin-4-ylhydrogensulfateCS-01579424-Pyrimidinol, 2,5,6-triamino-, 4-(hydrogen sulfate)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID20862708

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE

INCI name

2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE

Description

4-Hydroxy-2,5,6- triaminopyrimidine sulfate

Record provenance

Inventory reference: 54184
Imported identity: 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE
Source update: 13/03/2018

European Commission CosIng source notes

Annex records for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE

Annex III Restriction reference

Entry 301

2,5,6-TRIAMINO- 4-PYRIMIDINOL SULFATE

CAS: 1603-02-7

EC: 216-500-9

Key data

CAS

1603-02-7

216-500-9

Restriction

III/301

Function

HAIR DYEING: Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#165 · 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE

Ingredients with overlapping formulation functions

2,4-DIAMINOPHENOLHAIR DYEING

2,4-DIAMINOPHENOL HCLHAIR DYEING

2,4-DIAMINOPHENOXYETHANOL HCLHAIR DYEING

2,4-DIAMINOPHENOXYETHANOL SULFATEHAIR DYEING

2,6-BIS(2-HYDROXYETHOXY)-3,5-PYRIDINEDIAMINE HCLHAIR DYEING

2,6-DIAMINO-3-((PYRIDIN-3-YL)AZO)PYRIDINEHAIR DYEING

2,6-DIAMINOPYRIDINEHAIR DYEING

2,6-DIAMINOPYRIDINE SULFATEHAIR DYEING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE appears in the CosIng inventory

The CosIng inventory lists 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE reads: "III/301". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE carries the following function designation(s):

HAIR DYEING

CAS 1603-02-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE

This page combines the CosIng inventory entry for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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