What does the restriction note for 4-METHOXYTOLUENE-2,5-DIAMINE HCL mean?

The restriction field for 4-METHOXYTOLUENE-2,5-DIAMINE HCL reads: II/1221. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 56496-88-9?

CAS 56496-88-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains 4-METHOXYTOLUENE-2,5-DIAMINE HCL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 4170315/10/2010

4-METHOXYTOLUENE-2,5-DIAMINE HCL

4-Methoxytoluene-2,5-Diamine hydrochloride

4-METHOXYTOLUENE-2,5-DIAMINE HCL is linked to 1 EU annex record on this page. Inventory note: II/1221.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Prohibited Open this evidence	1	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Evidence linked Prohibited Open this evidence	1	English
ASEAN	Evidence linked Prohibited Open this evidence	1	English and national languages
China	Evidence linked Prohibited Open this evidence	1	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Evidence linked Prohibited Open this evidence	1	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Evidence linked Prohibited Open this evidence	1	Portuguese with INCI crosswalks
India	Evidence linked Prohibited Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Prohibited Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 56496-88-9

CAS 56496-88-9PubChem CID 71587185

4-Methoxytoluene-2,5-diamine dihydrochloride

IUPAC name: 2-methoxy-5-methylbenzene-1,4-diamine;dihydrochloride

Molecular formula: C8H14Cl2N2O
Molecular weight: 225.11 g/mol
Exact mass: 224.0483185 Da
Topological polar surface area: 61.3 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 3
Covalent units: 3
Defined stereocentres: 0

Also known as

X9JJM46RYT4-Methoxytoluene-2,5-diamine HClUNII-X9JJM46RYT2-Methyl-5-methoxy-p-phenylenediamine dihydrochloride4-Methoxytoluene-2,5-diamine hydrochloride2-Methoxy-5-methyl-p-phenylenediamine dihydrochloride1,4-Benzenediamine, 2-methoxy-5-methyl-, dihydrochloride2-METHOXY-5-METHYL-1,4-PHENYLENEDIAMINE HYDROCHLORIDE

7 more reported names

RefChem:996784-METHOXYTOLUENE-2,5-DIAMINE HCL [INCI]2-Methoxy-5-methylbenzene-1,4-diamine dihydrochlorideMAUAYDDABCDBRG-UHFFFAOYSA-N2-methoxy-5-methyl paraphenylenediamine dihydrochloride2-methyl-5-methoxy paraphenylene diamine dihydrochloride2-Methoxy-5-methylbenzene-1,4-diamine--hydrogen chloride (1/2)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID20205035

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for 4-METHOXYTOLUENE-2,5-DIAMINE HCL

INCI name

4-METHOXYTOLUENE-2,5-DIAMINE HCL

Description

4-Methoxytoluene-2,5-Diamine hydrochloride

Record provenance

Inventory reference: 41703
Imported identity: 4-METHOXYTOLUENE-2,5-DIAMINE HCL
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for 4-METHOXYTOLUENE-2,5-DIAMINE HCL

Annex II Restriction reference

Entry 1221

4-Methoxytoluene-2,5-diamine and its HCl salt, when used as a substance in hair dye products

CAS: 56496-88-9

Key data

CAS

56496-88-9

—

Restriction

II/1221

Function

HAIR DYEING: Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#336 · 4-METHOXYTOLUENE-2,5-DIAMINE HCl

Ingredients with overlapping formulation functions

4-FORMYL-1-METHYLQUINOLINIUM-P-TOLUENESULFONATEHAIR DYEING

4-HYDROXY-2-METHOXYBENZALDEHYDEHAIR DYEING

4-HYDROXYINDOLEHAIR DYEING

4-HYDROXYPROPYLAMINO-3-NITROPHENOLHAIR DYEING

4-METHYLBENZYL 4,5-DIAMINO PYRAZOLE SULFATEHAIR DYEING

4-NITRO-M-PHENYLENEDIAMINEHAIR DYEING

4-NITRO-M-PHENYLENEDIAMINE SULFATEHAIR DYEING

4-NITRO-O-PHENYLENEDIAMINEHAIR DYEING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How 4-METHOXYTOLUENE-2,5-DIAMINE HCL appears in the CosIng inventory

The CosIng inventory lists 4-METHOXYTOLUENE-2,5-DIAMINE HCL as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

4-METHOXYTOLUENE-2,5-DIAMINE HCL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

4-METHOXYTOLUENE-2,5-DIAMINE HCL appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for 4-METHOXYTOLUENE-2,5-DIAMINE HCL reads: "II/1221". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, 4-METHOXYTOLUENE-2,5-DIAMINE HCL carries the following function designation(s):

HAIR DYEING

CAS 56496-88-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for 4-METHOXYTOLUENE-2,5-DIAMINE HCL

This page combines the CosIng inventory entry for 4-METHOXYTOLUENE-2,5-DIAMINE HCL with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research 4-METHOXYTOLUENE-2,5-DIAMINE HCL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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