ZINGERONE
4-(4-Hydroxy-3-methoxyphenyl)butan-2-one
ZINGERONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
Zingerone
Zingerone is a methyl ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at positions 3 and 4 by methoxy and hydroxy groups respectively. The major pungent component in ginger. It has a role as an antioxidant, a flavouring agent, a fragrance, an antiemetic, a radiation protective agent, an anti-inflammatory agent and a plant metabolite. It is a monomethoxybenzene, a member of phenols and a methyl ketone. — ChEBI
- IUPAC name
- 4-(4-hydroxy-3-methoxyphenyl)butan-2-one
- Molecular formula
- C11H14O3
- Molecular weight
- 194.23 g/mol
- Exact mass
- 194.094294304 Da
- XLogP3
- 0.8
- Topological polar surface area
- 46.5 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 3
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:68657
- ChEMBL:CHEMBL25894
- EPA DTXSID:DTXSID8047420
- PubMed:39620438
- PubMed:38897041
- PubMed:38595292
- PubMed:36822304
- PubMed:33845646
- PubMed:32905641
- PubMed:31476248
- PubMed:31454121
- PubMed:30720227
- PubMed:29289488
- PubMed:28904557
- PubMed:28442378
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 187-188 °C @ 14 mm Hg Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 141.00 to 0.50 °C. @ 0.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 187-188 °C (14 mm Hg) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Color/Form: Crystals from acetone, petroleum ether, ether plus petroleum ether Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.138-1.139 @ 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: APPROX 102 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 40.5 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 41 °C Source: Human Metabolome Database (HMDB)
- Odor: STRONG, PUNGENT ODOR REMINISCENT OF GINGER Source: Hazardous Substances Data Bank (HSDB)
- Odor: SWEET, SPICY AROMA Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Solid with a spicy pungent odor like ginger; [Merck Index] Commercial substance: Yellowish liquid; [HSDB] Solid; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Physical Description: Yellowish to yellow-brown crystalline mass, sweet, spicy, warm, heavy floral, mildly animal balsamic, vanilla like odour Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Refractive Index: INDEX OF REFRACTION: 1.5440-1.5450 @ 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Sparingly sol in water, petroleum ether; sol in ether, dil alkalies Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Very soluble in ethyl ether Source: Hazardous Substances Data Bank (HSDB)
- Solubility: SOLUBILITY 1:1 IN 50% ALCOHOL Source: Hazardous Substances Data Bank (HSDB)
- Solubility: slightly soluble in water Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: moderately soluble (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Note: This chemical does not meet GHS hazard criteria for 99.4% (1413 of 1421) of all reports. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 1413 of 1421 companies (only 0.6% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1421 reports by companies from 4 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 1413 of 1421 reports by companies.; There are 3 notifications provided by 8 of 1421 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Sources/Uses: Obtained from ginger root or prepared from vanillin and acetone; Used in fragrances, flavors, cosmetics, and spice oils; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: FLAVOR INGREDIENT Source: Hazardous Substances Data Bank (HSDB)
- Uses: Flavoring Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for ZINGERONE
INCI name
ZINGERONE
Description
4-(4-Hydroxy-3-methoxyphenyl)butan-2-one
Record provenance
- Inventory reference
- 41306
- Imported identity
- ZINGERONE
- Source update
- 02/03/2011
Annex records for ZINGERONE
Key data
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
How ZINGERONE appears in the CosIng inventory
The CosIng inventory lists ZINGERONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
ZINGERONE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for ZINGERONE
This page reproduces the CosIng inventory entry for ZINGERONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research ZINGERONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
Tools & next steps
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