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CAS 1125-21-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 4118602/03/2011

TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE

2,6,6-Trimethylcyclohex-2-ene-1,4-dione

TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 1125-21-9

CAS 1125-21-9PubChem CID 62374

Ketoisophorone

2,6,6-Trimethyl-2-cyclohexene-1,4-dione is a member of cyclohexenones. — ChEBI

IUPAC name: 2,6,6-trimethylcyclohex-2-ene-1,4-dione

Molecular formula: C9H12O2
Molecular weight: 152.19 g/mol
Exact mass: 152.083729621 Da
XLogP3: 1.0
Topological polar surface area: 34.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

2,6,6-Trimethyl-2-cyclohexene-1,4-dioneketo-Isophorone2-CYCLOHEXENE-1,4-DIONE, 2,6,6-TRIMETHYL-FEMA No. 342172WY3KLB5RRefChem:83049TMEC-E-D214-406-2

16 more reported names

4-Oxoisophorone4-KetoisophoroneOxopholoneOxophorone6-Oxoisophorone4-Oxo-alpha-isophorone3,5,5-Trimethyl-2-cyclohexene-1,4-dioneOxoisophorone2,6,6-Trimethyl-2-cyclohexen-1,4-dione3,5,5-Trimethylcyclohex-2-en-1,4-dione4-Oxoisophorone, >=98%, FGTox21_2011932,6,6-trimethylcyclohex-2-en-1,4-dione2,6,6-trimethylcyclohex-2-ene-1,4-dion3,5,5-trimethylcyclohex-2-ene-1,4-dione2,2,6-Trimethyl-cyclohex-5-en-1,4-dione

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:179251
EPA DTXSID:DTXSID9021685
PubMed:22272147
PubMed:20877229
PubMed:20860033
PubMed:20717668
PubMed:17193245
PubMed:16607527
PubMed:16599406
PubMed:16547703
PubMed:15464593
PubMed:15325173
PubMed:15162455
PubMed:12753838

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match62374

Attributed physical-property, hazard, environmental and use annotations.

Boiling Point: 92.00 to 94.00 °C. @ 11.00 mm Hg Source: Human Metabolome Database (HMDB)

Melting Point: 21 °C Source: Human Metabolome Database (HMDB)

Physical Description: Solid Source: Human Metabolome Database (HMDB)
Physical Description: White to colourless solid; Woody, musty sweet, aroma Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Solubility: slightly Source: Human Metabolome Database (HMDB)
Solubility: Slightly soluble in water Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Solubility: Soluble (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Note: This chemical does not meet GHS hazard criteria for 3.4% (54 of 1568) of reports. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (85.3%): Harmful if swallowed [Warning Acute toxicity, oral]; H317 (13.7%): May cause an allergic skin reaction [Warning Sensitization, Skin] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P261, P264, P270, P272, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 1568 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 54 of 1568 reports by companies.; There are 9 notifications provided by 1514 of 1568 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE

INCI name

TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE

Description

2,6,6-Trimethylcyclohex-2-ene-1,4-dione

Record provenance

Inventory reference: 41186
Imported identity: TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE
Source update: 02/03/2011

European Commission CosIng source notes

Annex records for TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE

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Key data

CAS

1125-21-9

214-406-2

Restriction

—

Function

PERFUMING: Used for perfume and aromatic raw materials.

Ingredients with overlapping formulation functions

TRIMETHYL-1,3-CYCLOHEXADIENYLBUTAN-2-ONEPERFUMING

TRIMETHYL-1-CYCLOHEXENYLACRYLONITRILEPERFUMING

TRIMETHYL-1-CYCLOHEXENYLBUTAN-2-ONEPERFUMING

TRIMETHYL-1-CYCLOHEXENYLBUTANE-1,3-DIONEPERFUMING

TRIMETHYL-2-CYCLOHEXENOLPERFUMING

TRIMETHYL-2-CYCLOHEXENYL-3-PENTANONE/2-PROPYNOLPERFUMING

TRIMETHYL-2-DECENE-6,8-DIONEPERFUMING

TRIMETHYL-3-CYCLOHEXENE-1-METHANETHIOLPERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE appears in the CosIng inventory

The CosIng inventory lists TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE carries the following function designation(s):

PERFUMING

CAS 1125-21-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE

This page reproduces the CosIng inventory entry for TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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