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InventoryRef 4093402/03/2011

PROPIONALDEHYDE

Propionaldehyde

PROPIONALDEHYDE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 123-38-6
CAS 123-38-6PubChem CID 527

Propanal

Propanal is an aldehyde that consists of ethane bearing a formyl substituent. The parent of the class of propanals. It has a role as an Escherichia coli metabolite. It is a member of propanals and an alpha-CH2-containing aldehyde. — ChEBI

IUPAC name
propanal
Molecular formula
C3H6O
Molecular weight
58.08 g/mol
Exact mass
58.041864811 Da
XLogP3
0.6
Topological polar surface area
17.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

PropionaldehydePropanaldehydePropylaldehydePropaldehydeMethylacetaldehyden-PropanalPropionalPropionic aldehyde
16 more reported names
1-PropanalPropylic aldehyden-PropionaldehydePropyl aldehydeAldehyde propionique1-PropanoneFEMA No. 2923FEMA Number 2923NCI-C61029AMJ2B4M67VNSC-6493CHEBI:17153RefChem:6675204-623-0ProponalPropanalaldehyde
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match527

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whene Source: CAMEO Chemicals
  • ERG2024, Guide 129P (Propionaldehyde): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H302 (19.9%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (91.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (19.6%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2074 reports by companies from 31 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P317, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 2 - Materials that readily undergo violent chemical changes at elevated temperatures and pressures. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Specific Notice: W - No water: Materials that react violently or explosively with water. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for propionaldehyde(SRC), using a log Kow of 0.59(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 50(SRC), determined from a log Kow of 0.59(2) and a regression-derived equation(3), indicates that propionaldehyde is expected to have very high mobility in soil(SRC). Volatilization of propionaldehyde from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 7.34X10-5 atm-cu m/mole(4). Propionaldehyde is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 317 mm Hg(5). Propionaldehyde reached 94% of its theoretical BOD in 4 weeks using an activated sludge inoculum in the Japanese MITI test, suggesting that biodegradation may be an important environmental fate process in soil(SRC). Propionaldehyde degrades by anaerobic biological treatment with 26% utilization being reported in a system with a 20 day hydraulic retention time(7). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 50(SRC), determined from a log Kow of 0.59(2) and a regression-derived equation(3), indicates that propionaldehyde is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 7.34X10-5 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 11 hrs and 5.8 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Propionaldehyde reached 94% of its theoretical BOD in 4 weeks using an activated sludge inoculum in the Japanese MITI test(7), suggesting that biodegradation may be an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), propionaldehyde, which has a vapor pressure of 317 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase propionaldehyde is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 18 or 20 hrs(SRC), calculated from rate constants of 2.11X10-11 cu cm/molecule-sec(3) and 1.96X10-11 cu cm/molecule-sec(4), respectively. The rate constant for the vapor-phase reaction of propionaldehyde with nitrate radical has been experimentally determined to be 6.0X10-13 cu cm/sec(3). This corresponds to an atmospheric half-life of about 1.3 hrs(SRC). The direct photolysis rate constant for propionaldehyde in air is about 4X10-5 sec-1(5), which corresponds to a half-life of about 4.8 hrs(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Propionaldehyde is used in the manufacture of plastics, in the synthesis of rubber chemicals, and as a disinfectant and preservative. Source: EPA Hazardous Air Pollutants
  • Sources/Uses: Used to make propionic acid, trimethylolethane, polyvinyl and other plastics, and rubber, medicinal, and agricultural chemicals; Also used as a disinfectant, preservative, and flavoring agent; [HSDB] Used as a chemical intermediate in closed systems and not contained in consumer products; [AIHA] Used almost exclusively (thought to be >99%) as a closed system intermediate and transported by bulk carrier; [OECD SIDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Using Disinfectants or Biocides [Category: Clean] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For Propionaldehyde (USEPA/OPP Pesticide Code: 202400) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Intermediate in the mfr of trimethylolethane for use in alkyd resin systems and, in certain cases, it is oxidized to propionic acid and reduced to propyl alcohol; in medicinal and agricultural chemical preparations. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Manufacture of propionic acid, polyvinyl and other plastics; synthesis of rubber chemicals; disinfectant; preservative Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Reported uses (ppm): (FEMA, 2005); Table: Reported uses (ppm): (FEMA, 2005) [Table#2979] Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Used as a synthetic flavoring... Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PROPIONALDEHYDE

INCI name

PROPIONALDEHYDE

Description

Propionaldehyde

Record provenance

Inventory reference
40934
Imported identity
PROPIONALDEHYDE
Source update
02/03/2011
European Commission CosIng source notes
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Key data

CAS
123-38-6
EC
204-623-0
Restriction
—
Function
PERFUMING
Used for perfume and aromatic raw materials.

Ingredients with overlapping formulation functions

PRENOLPERFUMING
PRENYL ACETATEPERFUMING
PRENYL BENZOATEPERFUMING
PROPENYL P-CYMENEPERFUMING
PROPYL ACETATEPERFUMING, SOLVENT
PROPYL BUTYRATEPERFUMING
PROPYL GALLATEANTIOXIDANT, PERFUMING
PROPYL OCTANOATEPERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How PROPIONALDEHYDE appears in the CosIng inventory

The CosIng inventory lists PROPIONALDEHYDE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PROPIONALDEHYDE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PROPIONALDEHYDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PROPIONALDEHYDE carries the following function designation(s):

CAS 123-38-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for PROPIONALDEHYDE

This page reproduces the CosIng inventory entry for PROPIONALDEHYDE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PROPIONALDEHYDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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