Is PIPERINE safe to use in EU cosmetics?

PIPERINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 94-62-2?

CAS 94-62-2 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 4091515/10/2010

PIPERINE

1-[(E, E)-5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-piperidine

PIPERINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 94-62-2

CAS 94-62-2PubChem CID 638024

Piperine

Piperine is a N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum. It has a role as a NF-kappaB inhibitor, a plant metabolite, a food component and a human blood serum metabolite. It is a tertiary carboxamide, a piperidine alkaloid, a member of benzodioxoles and a N-acylpiperidine. It is functionally related to an (E,E)-piperic acid. — ChEBI

IUPAC name: (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one

Molecular formula: C17H19NO3
Molecular weight: 285.34 g/mol
Exact mass: 285.13649347 Da
XLogP3: 3.5
Topological polar surface area: 38.8 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

1-PiperoylpiperidinePiperinBioperinePiperoylpiperidineFEMA No. 2909piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-(2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-oneNSC-21727

16 more reported names

U71XL721QKN-[(E,E)-Piperoyl]piperidine1-Piperoyl-piperidinePiperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (E,E)-CHEBI:28821Piperidine, 1-((2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-Piperidine, 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, (E,E)-N-((E,E)-Piperoyl)piperidinePiperine 1537RefChem:6145((1-5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine(1-(5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine202-348-07780-20-3(E,E)-1-piperoylpiperidine(2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:28821
ChEBI:CHEBI:93043
ChEMBL:CHEMBL43185
EPA DTXSID:DTXSID3021805
PubMed:40246250
PubMed:37244399
PubMed:36819991
PubMed:34838672
PubMed:30935902
PubMed:29968805
PubMed:28341137
PubMed:25655587
PubMed:25455453
PubMed:25087745
PubMed:23943324
PubMed:23942037

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PIPERINE

INCI name

PIPERINE

Description

1-[(E, E)-5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-piperidine

Record provenance

Inventory reference: 40915
Imported identity: PIPERINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PIPERINE

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Key data

CAS

94-62-2

202-348-0

Restriction

—

Function

PERFUMING: Used for perfume and aromatic raw materials.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#21236 · PIPERINE

Ingredients with overlapping formulation functions

PIPER CUBEBA FRUIT EXTRACTPERFUMING

PIPER CUBEBA FRUIT OILPERFUMING

PIPER NIGRUM FRUIT EXTRACTPERFUMING

PIPER NIGRUM FRUIT OILFRAGRANCE, PERFUMING

PIPERITONEPERFUMING

PIPERONYL ACETATEPERFUMING

PIPERONYL ACETONEPERFUMING

PISTACIA LENTISCUS GUM OILANTI-SEBORRHEIC, ANTIMICROBIAL, PERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PIPERINE appears in the CosIng inventory

The CosIng inventory lists PIPERINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PIPERINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PIPERINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PIPERINE carries the following function designation(s):

PERFUMING

CAS 94-62-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PIPERINE

This page reproduces the CosIng inventory entry for PIPERINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PIPERINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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