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CAS 3943-74-6 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 4083402/03/2011

METHYL VANILLATE

Methyl 4-hydroxy-3-methoxy-benzoate

METHYL VANILLATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 3943-74-6

CAS 3943-74-6PubChem CID 19844

Methyl Vanillate

Methyl vanillate is a benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite. It is a member of phenols, an aromatic ether and a benzoate ester. It is functionally related to a vanillic acid. — ChEBI

IUPAC name: methyl 4-hydroxy-3-methoxybenzoate

Molecular formula: C9H10O4
Molecular weight: 182.17 g/mol
Exact mass: 182.05790880 Da
XLogP3: 1.8
Topological polar surface area: 55.8 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

Methyl 3-methoxy-4-hydroxybenzoateVanillic acid, methyl ester4-Hydroxy-3-methoxybenzoic acid methyl esterBENZOIC ACID, 4-HYDROXY-3-METHOXY-, METHYL ESTER2HXG8QSO3D4-hydroxy-3-methoxy methyl benzoateNSC-74385CHEBI:46477

16 more reported names

RefChem:158055223-525-9Vanillic acid methyl esterVanillic acid methylmethyl 4-hydroxy-3-methoxy-benzoate4-hydroxy-5-methoxy-benzoic acid methyl ester3-methoxy-4-(hydroxy)benzoic acid methyl esterMethylvanillateVXXEINECS 223-525-9UNII-2HXG8QSO3DNSC 74385BRN 1369113AI3-20212methyl4-hydroxy-3-methoxybenzoateMethyl vanillate, 99%

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:46477
ChEMBL:CHEMBL486214
EPA DTXSID:DTXSID5074345
PubMed:35523312
PubMed:22688032
PubMed:22313772
PubMed:21966246
PubMed:21732721
PubMed:21582019
PubMed:21581848
PubMed:20877647
PubMed:20302370
PubMed:19601669
PubMed:19034929
PubMed:18792767

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for METHYL VANILLATE

INCI name

METHYL VANILLATE

Description

Methyl 4-hydroxy-3-methoxy-benzoate

Record provenance

Inventory reference: 40834
Imported identity: METHYL VANILLATE
Source update: 02/03/2011

European Commission CosIng source notes

Annex records for METHYL VANILLATE

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Key data

CAS

3943-74-6

223-525-9

Restriction

—

Function

PERFUMING: Used for perfume and aromatic raw materials.

Ingredients with overlapping formulation functions

METHYL TRIMETHYLHEXYLIDENE-AMINOBENZOATEPERFUMING

METHYL UNDECENOATEPERFUMING

METHYL UNDECYLENATEDEODORANT, PERFUMING

METHYL VALERATEPERFUMING

METHYL-CYCLOHEXENYLIDENE-PENTANALPERFUMING

METHYL-ISOPROPYLCYCLOHEXANOLPERFUMING

METHYL-METHYLBICYCLOHEPTENYL-PENTENOLPERFUMING

METHYL-METHYLCYCLOHEXENYL-ETHYL BUTYRATEPERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How METHYL VANILLATE appears in the CosIng inventory

The CosIng inventory lists METHYL VANILLATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

METHYL VANILLATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

METHYL VANILLATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, METHYL VANILLATE carries the following function designation(s):

PERFUMING

CAS 3943-74-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for METHYL VANILLATE

This page reproduces the CosIng inventory entry for METHYL VANILLATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research METHYL VANILLATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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