Is METHYL TIGLATE safe to use in EU cosmetics?

METHYL TIGLATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 6622-76-0?

CAS 6622-76-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains METHYL TIGLATE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 4081102/03/2011

METHYL TIGLATE

Methyl (E)-2-Methyl-2-butenoate; Methyl 2-Methylcrotonate

METHYL TIGLATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 6622-76-0

CAS 6622-76-0PubChem CID 5323652

2-Butenoic acid, 2-methyl-, methyl ester, (2E)-

Methyl tiglate is a fatty acid ester. — ChEBI

IUPAC name: methyl (E)-2-methylbut-2-enoate

Molecular formula: C6H10O2
Molecular weight: 114.14 g/mol
Exact mass: 114.068079557 Da
XLogP3: 1.3
Topological polar surface area: 26.3 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

Methyl tiglateMethyl 2-methylcrotonateMethyl (E)-2-methylcrotonateMethyl alpha-methylcrotonateMethyl trans-2-methylcrotonateEINECS 229-575-8NSC 55277BRN 1720455

16 more reported names

AI3-35988Crotonic acid, 2-methyl-, methyl ester, (E)-2-Carbomethoxy-2-butene, (E)-Methyl trans-2-methyl-2-butenoateTiglic acid, methyl ester (6CI,7CI)RefChem:468004Crotonic acid, 2-methyl-, methyl ester, (E)-(8CI)229-575-8InChI=1/C6H10O2/c1-4-5(2)6(7)8-3/h4H,1-3H3/b5-4Tiglic acid methyl esterMETHYLTIGLATEMethyl 2-methyl-2-butenoate2-Butenoic acid, 2-methyl-, methyl ester(E)-methyl 2-methylbut-2-enoateEINECS 255-518-1Methyl cis-2-methylcrotonate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:185318
ChEMBL:CHEMBL55121
EPA DTXSID:DTXSID30878830

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for METHYL TIGLATE

INCI name

METHYL TIGLATE

Description

Methyl (E)-2-Methyl-2-butenoate; Methyl 2-Methylcrotonate

Record provenance

Inventory reference: 40811
Imported identity: METHYL TIGLATE
Source update: 02/03/2011

European Commission CosIng source notes

Annex records for METHYL TIGLATE

Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search annex entries

Search the annex database for entries matching METHYL TIGLATE or related substances.

Key data

CAS

6622-76-0

229-575-8

Restriction

—

Function

PERFUMING: Used for perfume and aromatic raw materials.

Ingredients with overlapping formulation functions

METHYL ROSINATEFILM FORMING, PERFUMING, SKIN CONDITIONING

METHYL SALICYLATEDENATURANT, FLAVOURING, ORAL CARE, PERFUMING, SOOTHING

METHYL TETRAHYDROAZEPINYL ETHERPERFUMING

METHYL THIAZOLYL KETONEPERFUMING

METHYL TRANS-1,4-DIMETHYL-CYCLOHEXANECARBOXYLATEPERFUMING

METHYL TRIMETHYLHEXYLIDENE-AMINOBENZOATEPERFUMING

METHYL UNDECENOATEPERFUMING

METHYL UNDECYLENATEDEODORANT, PERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How METHYL TIGLATE appears in the CosIng inventory

The CosIng inventory lists METHYL TIGLATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

METHYL TIGLATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

METHYL TIGLATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, METHYL TIGLATE carries the following function designation(s):

PERFUMING

CAS 6622-76-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for METHYL TIGLATE

This page reproduces the CosIng inventory entry for METHYL TIGLATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research METHYL TIGLATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect METHYL TIGLATE and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to METHYL TIGLATE, its identifiers or nearby name variants.