Is PHYTOL safe to use in EU cosmetics?

PHYTOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What function does PHYTOL serve in cosmetics?

According to the EU CosIng inventory, PHYTOL carries the following function designation(s): FRAGRANCE, PERFUMING, SKIN CONDITIONING - EMOLLIENT.

How do I check if my formula contains PHYTOL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 4064715/10/2010

PHYTOL

3,7,11-15-Tetramethylhexadec-2-en-1-ol

PHYTOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 150-86-7

CAS 150-86-7PubChem CID 5280435

Phytol

Phytol is a diterpenoid that is hexadec-2-en-1-ol substituted by methyl groups at positions 3, 7, 11 and 15. It has a role as a schistosomicide drug, a plant metabolite and an algal metabolite. It is a diterpenoid and a long-chain primary fatty alcohol. — ChEBI

IUPAC name: (E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol

Molecular formula: C20H40O
Molecular weight: 296.5 g/mol
Exact mass: 296.307915895 Da
XLogP3: 8.2
Topological polar surface area: 20.2 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 2

Also known as

trans-Phytol(2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-olMZQ4XE15TPCHEBI:17327PHYTOL, (E)-3R,7R,11R,15-tetramethyl-2E-hexadecen-1-olFEMA NO. 4196, E-2-Hexadecen-1-ol, 3,7,11,15-tetramethyl-, (7R,11R)-

16 more reported names

RefChem:6139205-776-62-Hexadecen-1-ol, 3,7,11,15-tetramethyl-, (R-(R*,R*))-5BC2RZ81NGFEMA No. 4196Phytol, (E,Z)-(E)-Phytol2-Hexadecen-1-ol, 3,7,11,15-tetramethyl-, (2E,7R,11R)-(7R,11R,E)-3,7,11,15-Tetramethylhexadec-2-en-1-olUNII-MZQ4XE15TPEINECS 205-776-62-Hexadecen-1-ol, 3,7,11,15-tetramethyl-, (R-(R*,R*-(E)))-3,7,11,15-Tetramethylhexadec-2-en-1-ol(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol(7R,11R,2E)-PHYTOL2-Hexadecen-1-ol, 3,7,11,15-tetramethyl-, [R-[R*,R*-(E)]]-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:17327
ChEMBL:CHEMBL1644111
EPA DTXSID:DTXSID1040586
PubMed:30520250
PubMed:29486182
PubMed:28344896
PubMed:24853760
PubMed:19188468
PubMed:17015885
PubMed:12672152
PubMed:12410555
PubMed:11731906
PubMed:9491760

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 7541-49-3

CAS 7541-49-3PubChem CID 5366244

3,7,11,15-Tetramethyl-2-hexadecen-1-OL

3,7,11,15-tetramethylhexadec-2-en-1-ol has been reported in Excoecaria acerifolia, Artemisia carvifolia, and other organisms with data available. — LOTUS - the natural products occurrence database

IUPAC name: (E)-3,7,11,15-tetramethylhexadec-2-en-1-ol

Molecular formula: C20H40O
Molecular weight: 296.5 g/mol
Exact mass: 296.307915895 Da
XLogP3: 8.2
Topological polar surface area: 20.2 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

2-hexadecen-1-ol, 3,7,11,15-tetramethylRefChem:9107543,7,11,15-Tetramethylhexadec-2-en-1-ol(2E)-3,7,11,15-tetramethylhexadec-2-en-1-olAI3-36488Vitamin K1 Impurity 183(E)-3,7,11,15-tetramethyl-2-hexadecen-1-olPhytol, >=97%, FG

16 more reported names

(2E)-3,7,11,15-Tetramethyl-2-hexadecen-1-ol3,7,11,15-teramethyl-2-hexadecene-1-ol-, (2E,7R,11R)-3,7,11,15-Tetramethyl-2-hexadecen-1-ol-, (2E,7R,11R)-HMS5084L073,7,11,15-Tetramethyl-2-hexadecen-1-ol (mixture of isomers)EBC-46239EBC-46241CCG-267435HY-W107616AS-47652LS-14831CS-0161167EN300-16645EN300-7399953Phytol 3,7,11,15-Tetramethyl-2-hexadecen-1-ol4305EBEF-F02F-4CB0-985E-89469C273922

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL390773

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PHYTOL

INCI name

PHYTOL

Description

3,7,11-15-Tetramethylhexadec-2-en-1-ol

Record provenance

Inventory reference: 40647
Imported identity: PHYTOL
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PHYTOL

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Key data

CAS

150-86-7 / 7541-49-3

205-776-6 / -

Restriction

—

Function

FRAGRANCE: Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
PERFUMING: Used for perfume and aromatic raw materials.
SKIN CONDITIONING - EMOLLIENT: Acting as lubricants on the skin surface providing the skin with a soft and smooth appearance.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#20895 · PHYTOL

Ingredients with overlapping formulation functions

PHENYLMETHYLPENTANALFRAGRANCE, PERFUMING

PHENYLPROPANOLFRAGRANCE, PERFUMING, SOLVENT

PHIALOPHORA PARASITICA/AQUILARIA AGALLOCHA WOOD FERMENT POWDERFRAGRANCE

PHOENIX DACTYLIFERA LEAF CELL EXTRACTFRAGRANCE, SKIN PROTECTING

PHYTYL VANILLINYL SUCCINATEFRAGRANCE; SKIN CONDITIONING - MISCELLANEOUS

PICEA ABIES LEAF OILFRAGRANCE

PICEA ENGELMANNII OILFRAGRANCE; PERFUMING

PICEA GLAUCA BRANCH/LEAF OILFRAGRANCE

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PHYTOL appears in the CosIng inventory

The CosIng inventory lists PHYTOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PHYTOL is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PHYTOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PHYTOL carries the following function designation(s):

CAS 150-86-7 / 7541-49-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for PHYTOL

This page reproduces the CosIng inventory entry for PHYTOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PHYTOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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