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CAS 121251-67-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 4057802/03/2011

PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE

(1alpha,3alpha,6alpha)-2',2',3,7,7-Pentamethyl-spiro[bicyclo[4.1.0]heptane-2,5'-[1,3]dioxane]

PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 121251-67-0

CAS 121251-67-0PubChem CID 44152459

Spiro(bicyclo(4.1.0)heptane-2,5'-(1,3)dioxane), 2',2',3,7,7-pentamethyl-, (1R,3S,6S)-rel-

IUPAC name: (1'R,3'S,6'S)-2,2,3',7',7'-pentamethylspiro[1,3-dioxane-5,2'-bicyclo[4.1.0]heptane]

Molecular formula: C15H26O2
Molecular weight: 238.37 g/mol
Exact mass: 238.193280068 Da
XLogP3: 3.7
Topological polar surface area: 18.5 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 3

Also known as

Spiro(bicyclo(4.1.0)heptane-2,5'-(1,3)dioxane), 2',2',3,7,7-pentamethyl-, (1alpha,3alpha,6alpha)-Spiro[bicyclo[4.1.0]heptane-2,5'-[1,3]dioxane], 2',2',3,7,7-pentamethyl-, (1R,3S,6S)-rel-RefChem:184787rel-(1R,3R,6S)-2',2',3,7,7-Pentamethylspiro[bicyclo[4.1.0]heptane-2,5'-[1,3]dioxane]Spirobicyclo4.1.0heptane-2,5-1,3dioxane, 2,2,3,7,7-pentamethyl-, (1R,3S,6S)-rel-ORHSGDMSYGKJJY-SDDRHHMPSA-N

Open full PubChem record PubChem annotations 3D structure image

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match44152459

Attributed physical-property, hazard, environmental and use annotations.

Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H315 (> 99.9%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (96.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 1336 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H315 (99.2%): Causes skin irritation [Warning Skin corrosion/irritation]; H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P264, P273, P280, P302+P352, P321, P332+P317, P362+P364, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 132 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE

INCI name

PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE

Description

(1alpha,3alpha,6alpha)-2',2',3,7,7-Pentamethyl-spiro[bicyclo[4.1.0]heptane-2,5'-[1,3]dioxane]

Record provenance

Inventory reference: 40578
Imported identity: PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE
Source update: 02/03/2011

European Commission CosIng source notes

Annex records for PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE

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Key data

CAS

121251-67-0

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Restriction

—

Function

PERFUMING: Used for perfume and aromatic raw materials.

Ingredients with overlapping formulation functions

PENTADECALACTONEFRAGRANCE, PERFUMING

PENTADECANEPERFUMING

PENTAMETHYL-2-HEPTANOLPERFUMING

PENTAMETHYL-CYCLOPENT-1-ENYL METHYL KETONEPERFUMING

PENTAMETHYLCYCLOHEXANEPROPANOLPERFUMING

PENTAMETHYLCYCLOPENT-3-ENE-BUTANOLPERFUMING

PENTAMETHYLHEPTENONEPERFUMING

PENTANEDIONEPERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE appears in the CosIng inventory

The CosIng inventory lists PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE carries the following function designation(s):

PERFUMING

CAS 121251-67-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE

This page reproduces the CosIng inventory entry for PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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